Tung Biomedical Sciences Centre, City University of Hong Kong
Tung Biomedical Sciences Centre, City University of Hong Kong

Our selection of publications highlights the diverse research efforts undertaken at the Centre. Each paper reflects our commitment to advancing biomedical science through rigorous investigation and collaboration.

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Cellulose Nanofibrils of High Immunoaffinity for Efficient Enrichment of Small Extracellular Vesicles

Z. Wang, J. Dai, H. He, T. Si, K. Ng, S. Zheng, X. Zhou, Z. Zhou, H. Yuan, M. Yang (2024). Cellulose Nanofibrils of High Immunoaffinity for Efficient Enrichment of Small Extracellular Vesicles. Small Methods, 8:2400426.
doi: 10.1002/smtd.202400426

Size and shape control of microgel-encapsulating tumor spheroid via a user-friendly solenoid valve-based sorter and its application on precise drug testing

J. Sun, W. Li, Y. Lu, Z. Zhou, L. Tian, T. Si, Z. Wang, Y. Xu, D. Sun, C.-H. Chen, M. Yang (2024). Size and shape control of microgel-encapsulating tumor spheroid via a user-friendly solenoid valve-based sorter and its application on precise drug testing. Biosensors and Bioelectronics, 264:116614.
doi: 10.1016/j.bios.2024.116614

Distinguishing high-metastasis-potential circulating tumor cells through fluidic shear stress in a bloodstream-like microfluidic circulatory system

W. Li, Z. Guo, Z. Zhou, Z. Zhou, H. He, J. Sun, X. Zhou, Y. R. Chin, L. Zhang, M. Yang (2024). Distinguishing high-metastasis-potential circulating tumor cells through fluidic shear stress in a bloodstream-like microfluidic circulatory system. Oncogene, 43:2295–2306.
doi: 10.1038/s41388-024-03075-4

Magnetic particle imaging: from tracer design to biomedical applications in vasculature abnormality

X. Xie, J. Zhai, X. Zhou, et al. (2024). Magnetic particle imaging: from tracer design to biomedical applications in vasculature abnormality. Advanced Materials, 36(17):2306450.
doi: 10.1002/adma.202306450

Extracellular Vesicle Preparation and Analysis: A State-of-the-Art Review

Z. Wang, X. Zhou, Q. Kong, H. He, J. Sun, W. Qiu, L. Zhang, M. Yang. (2024). Extracellular Vesicle Preparation and Analysis: A State-of-the-Art Review. Advanced Science, 11(30):2401069.
doi: 10.1002/advs.202401069

Distinguishing High-Metastasis-Potential Circulating Tumor Cells through Fluidic Shear Stress in a Bloodstream-Like Microfluidic Circulatory System

W. Li, Z. Guo, Z. Zhou, et al. (2024). Distinguishing High-Metastasis-Potential Circulating Tumor Cells through Fluidic Shear Stress in a Bloodstream-Like Microfluidic Circulatory System. Oncogene, 43:2295–2306.
doi: 10.1038/s41388-024-03075-4

Size and shape control of microgel-encapsulating tumor spheroid via a user-friendly solenoid valve-based sorter and its application on precise drug testing

J. Sun, W. Li, Z. Zhou, et al. (2024). Size and shape control of microgel-encapsulating tumor spheroid via a user-friendly solenoid valve-based sorter and its application on precise drug testing. Biosensors and Bioelectronics, 264:116614.
doi: 10.1016/j.bios.2024.116614

Daily oral administration of probiotics engineered to constantly secrete short-chain fatty acids effectively prevents myocardial injury from subsequent ischemic heart disease

Q. H. Pham, T. V. A. Bui, W. Sim, et al. (2024). Daily oral administration of probiotics engineered to constantly secrete short-chain fatty acids effectively prevents myocardial injury from subsequent ischemic heart disease. Cardiovascular Research, cvae128.
doi: 10.1093/cvr/cvae128

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy

K. Tafess, T. T. Ng, K. K. Tam, et al. (2024). Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy. Microbiology Spectrum, 12:e02133–23.
doi: 10.1128/spectrum.02133-23

Hfq mediates transcriptome-wide RNA structurome reprogramming under virulence-inducing conditions in a phytopathogen

C. Hua, J. Huang, Y. Sun, et al. (2024). Hfq mediates transcriptome-wide RNA structurome reprogramming under virulence-inducing conditions in a phytopathogen. Cell Reports, 43(8):114544.
doi: 10.1016/j.celrep.2024.114544

DNA methylome regulates virulence and metabolism in Pseudomonas syringae

J. Huang, F. Chen, B. Lu, et al. (2024). DNA methylome regulates virulence and metabolism in Pseudomonas syringae. eLife, 13:RP96290.
doi: 10.7554/eLife.96290.1

Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae

Y. Sun, J. Li, J. Huang, et al. (2024). Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae. eLife, 13:RP96172.
doi: 10.7554/eLife.96172.1

Quantitative comparison of the renal pelvic urine and bladder urine to examine modifications of the urine proteome by the lower urinary tract

Y. Pan, C. Y. Wong, H. Ma, et al. (2024). Quantitative comparison of the renal pelvic urine and bladder urine to examine modifications of the urine proteome by the lower urinary tract. Proteomics – Clinical Applications, 18(2):e2300004.
doi: 10.1002/prca.202300004

Monitoring hepatocellular carcinoma using tumor content in circulating cell-free DNA

S. Lian, C. Lu, F. Li, et al. (2024). Monitoring hepatocellular carcinoma using tumor content in circulating cell-free DNA. Clinical Cancer Research, 30(13):2772–2779.
doi: 10.1158/1078-0432.CCR-23-3449

Circulating DNA genome-wide fragmentation in early detection and disease monitoring of hepatocellular carcinoma

S. Lian, C. Lu, F. Li, et al. (2024). Circulating DNA genome-wide fragmentation in early detection and disease monitoring of hepatocellular carcinoma. iScience, 27(5):109701.
doi: 10.1016/j.isci.2024.109701

On-chip droplet analysis and cell spheroid screening by capillary wrapping enabled shape-adaptive ferrofluid transporters

X. Wang, X. Li, A. Pu, et al. (2024). On-chip droplet analysis and cell spheroid screening by capillary wrapping enabled shape-adaptive ferrofluid transporters. Lab on a Chip, 24(6):1782–1793.
doi: 10.1039/d3lc00906h

Inducing Immunogenic Cancer Cell Death through Oxygen-Economized Photodynamic Therapy with Nitric Oxide-Releasing Photosensitizers

F. Xu, M. Wang, E. Dotse, et al. (2024). Inducing Immunogenic Cancer Cell Death through Oxygen-Economized Photodynamic Therapy with Nitric Oxide-Releasing Photosensitizers. Angewandte Chemie International Edition, e202404561.
doi: 10.1002/anie.202404561

TLR4 sensitizes plasmacytoid dendritic cells for antiviral response against SARS-CoV-2 coronavirus

K. H. Lim, L. Wang, E. Dotse, et al. (2024). TLR4 sensitizes plasmacytoid dendritic cells for antiviral response against SARS-CoV-2 coronavirus. Journal of Leukocyte Biology, 115(1):190–200.
doi: 10.1093/jleuko/qiad111

Protocol to induce neurodegeneration in a local area of the mouse brain

X. Zhang, Q. Lu, X. Meng, J. Y. Kim. (2024). Protocol to induce neurodegeneration in a local area of the mouse brain. STAR Protocols, 5(3):103243.
doi: 10.1016/j.xpro.2024.103243

Cell-type specific circadian transcription factor BMAL1 roles in excitotoxic hippocampal lesions to enhance neurogenesis

X. Zhang, S. Huang, J. Y. Kim. (2024). Cell-type specific circadian transcription factor BMAL1 roles in excitotoxic hippocampal lesions to enhance neurogenesis. iScience, 27(2):108829.
doi: 10.1016/j.isci.2024.108829

Biomarker discovery and metabolic profiling in serum of cardiovascular disease patients with untargeted metabolomics and machine learning

X. Shen, S. Guo, N. Liang, et al. (2024). Biomarker discovery and metabolic profiling in serum of cardiovascular disease patients with untargeted metabolomics and machine learning. Clinical and Translational Medicine, 14(6):e1722.
doi: 10.1002/ctm2.1722

Fatty acid oxidation-induced HIF-1α activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH

N. Liang, X. Yuan, L. Zhang, et al. (2024). Fatty acid oxidation-induced HIF-1α activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH. Life Metabolism, 3(5):loae018.
doi: 10.1093/lifemeta/loae018

A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy

L. Pang, N. Liang, C. Li, et al. (2024). A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870(3):167009.
doi: 10.1016/j.bbadis.2023.167009

Amyloid-β oligomer-induced neurotoxicity by exosomal interactions between neuron and microglia

M. K. Tong, A. Thakur, T. Yang, et al. (2024). Amyloid-β oligomer-induced neurotoxicity by exosomal interactions between neuron and microglia. Biochemical and Biophysical Research Communications, 727:150312.
doi: 10.1016/j.bbrc.2024.150312

Liquid Metal-Enhanced Highly Adhesive Electrodes for Multiple Functional Epidermal Bioelectronics

C. Cao, C. Hou, X. Wang, et al. (2024). Liquid Metal-Enhanced Highly Adhesive Electrodes for Multiple Functional Epidermal Bioelectronics. Advanced Functional Materials, 2403671.
doi: 10.1002/adfm.202403671

Targeting Ser78 phosphorylation achieves potent antiviral effects against enterovirus A71 infections

M. Wu, Q. Wan, X. Dan, et al. (2024). Targeting Ser78 phosphorylation achieves potent antiviral effects against enterovirus A71 infections. Emerging Microbes and Infections, 13(1):2368221.
doi: 10.1080/22221751.2024.2368221

Attention-Based MultiOffset Deep Learning Reconstruction of Chemical Exchange Saturation Transfer (AMO-CEST) MRI

Z. Yang, D. Shen, K. W. Y. Chan, J. Huang (2024). Attention-Based MultiOffset Deep Learning Reconstruction of Chemical Exchange Saturation Transfer (AMO-CEST) MRI. IEEE Journal of Biomedical and Health Informatics, 28(8):4636–4647.
doi: 10.1109/JBHI.2024.3404225

The effect of aquaporin-4 inhibition on cerebrospinal fluid-tissue water exchange in mouse brain detected by magnetization transfer indirect spin labeling MRI

Z. Chen, J. H. C. Lai, J. Xu, et al. (2024). The effect of aquaporin-4 inhibition on cerebrospinal fluid-tissue water exchange in mouse brain detected by magnetization transfer indirect spin labeling MRI. NMR in Biomedicine, 37(7):e5093.
doi: 10.1002/nbm.5093

Deep-learning-based super-resolution for accelerating chemical exchange saturation transfer MRI

R. S. P. Prabakaran, J. Huang, K. W. Y. Chan (2024). Deep-learning-based super-resolution for accelerating chemical exchange saturation transfer MRI. NMR in Biomedicine, 37(8):e5130.
doi: 10.1002/nbm.5130

Effect of inhaled oxygen level on dynamic glucose-enhanced MRI in mouse brain

J. Huang, Z. Chen, P. C. M. van Zijl, et al. (2024). Effect of inhaled oxygen level on dynamic glucose-enhanced MRI in mouse brain. Magnetic Resonance in Medicine, 92(1):57–68.
doi: 10.1002/mrm.30035

Preclinical application of CEST MRI to detect early and regional tumor response to local brain tumor treatment

S. W. Park, J. H. C. Lai, X. Han, et al. (2024). Preclinical application of CEST MRI to detect early and regional tumor response to local brain tumor treatment. Pharmaceutics, 16(1):101.
doi: 10.3390/pharmaceutics16010101

Role of cytokines in Alzheimer’s disease

Z. Chen, Y. L. Balachandran, W. P. Chong, K. W. Y. Chan (2024). Role of cytokines in Alzheimer’s disease. International Journal of Molecular Sciences, 25(11):5803.
doi: 10.3390/ijms25115803

Editorial for “Multi-parametric MRI for evaluating variations in renal structure, function and endogenous metabolites in an animal model with acute kidney injury induced by ischemia reperfusion”

J. Huang, K. W. Y. Chan (2024). Editorial for “Multi-parametric MRI for evaluating variations in renal structure, function and endogenous metabolites in an animal model with acute kidney injury induced by ischemia reperfusion”. Journal of Magnetic Resonance Imaging, 60(1):256–257.
doi: 10.1002/jmri.29096

Coordinate-based neural representations for computational adaptive optics in widefield microscopy

I. Kang, Q. Zhang, S. X. Yu, et al. (2024) Coordinate-based neural representations for computational adaptive optics in widefield microscopy. Nature Machine Intelligence, 6:714–725
doi: 10.1038/s42256-024-00853-3

Self-assembly of nanoparticles with stimulated responses at liquid interfaces

Y. Fu, S. Zhao, W. Chen, et al. (2024) Self-assembly of nanoparticles with stimulated responses at liquid interfaces. Nano Today, 54:102073
doi: 10.1016/j.nantod.2023.102073

Graphene oxide aptasensor droplet assay for detection of metabolites secreted by single cells applied to synthetic biology

D. Zheng, J. Zhang, W. Jiang, et al. (2024) Graphene oxide aptasensor droplet assay for detection of metabolites secreted by single cells applied to synthetic biology. Lab on a Chip, 24(1):137–147
doi: 10.1039/d3lc00959a

TNA-Mediated Antisense Strategy to Knockdown Akt Genes for Triple-Negative Breast Cancer Therapy

L. Pan, S. Zheng, H. M. Leung, L. S. Liu, T. J. H. Chang, A. Maryam, F. Wang, Y. R. Chin, P. K. Lo (2024). TNA-Mediated Antisense Strategy to Knockdown Akt Genes for Triple-Negative Breast Cancer Therapy. Small Methods, 2400291.
doi: 10.1002/smtd.202400291

Comprehensive genomic and plasmid characterization of multidrug-resistant bacterial strains by R10.4.1 nanopore sequencing

L. Ye, X. Liu, Y. Ni, Y. Xu, Z. Zheng, K. Chen, Q. Hu, L. Tan, Z. Guo, C. K. W., E. W. C. Chan, R. Li, S. Chen (2024). Comprehensive genomic and plasmid characterization of multidrug-resistant bacterial strains by R10.4.1 nanopore sequencing. Microbiological Research, 283:127666.
doi: 10.1016/j.micres.2024.127666

Chromosome level genome assembly and transcriptome analysis of E11 cells infected by tilapia lake virus

X. Wang, X. Liu, L. Tan, L. Jahangiri, W. Cai, D. Y. Kim, R. Li (2024). Chromosome level genome assembly and transcriptome analysis of E11 cells infected by tilapia lake virus. Fish & Shellfish Immunology, 148:109505.
doi: 10.1016/j.fsi.2024.109505

Utilization of nanopore direct RNA sequencing to analyze viral RNA modifications

L. Tan, Z. Guo, X. Wang, D. Y. Kim, R. Li (2024). Utilization of nanopore direct RNA sequencing to analyze viral RNA modifications. mSystems, 9:e01163-23.
doi: 10.1128/msystems.01163-23

Nanopore Current Events Magnifier (nanoCEM): a novel tool for visualizing current events at modification sites of nanopore sequencing

Z. Guo, Y. Ni, L. Tan, Y. Shao, L. Ye, S. Chen, R. Li (2024). Nanopore Current Events Magnifier (nanoCEM): a novel tool for visualizing current events at modification sites of nanopore sequencing. NAR Genomics and Bioinformatics, 6(2):lqae052.
doi: 10.1093/nargab/lqae052

Analysis of bacterial transcriptome and epitranscriptome using nanopore direct RNA sequencing

L. Tan, Z. Guo, Y. Shao, L. Ye, M. Wang, X. Deng, S. Chen, R. Li (2024). Analysis of bacterial transcriptome and epitranscriptome using nanopore direct RNA sequencing. Nucleic Acids Research, gkae601.
doi: 10.1093/nar/gkae601

Theranostic DNA nanostructure based on phenotype-specific activation of antisense oligonucleotides

L. T. Chu, H. K. Kwong, C. Cui, T. H. Chen (2024). Theranostic DNA nanostructure based on phenotype-specific activation of antisense oligonucleotides. Talanta, 269:125399.
doi: 10.1016/j.talanta.2023.125399

On-Site Melanoma Diagnosis Utilizing a Swellable Microneedle-Assisted Skin Interstitial Fluid Sampling and a Microfluidic Particle Dam for Visual Quantification of S100A1

G. Wang, Y. Zhang, H. K. Kwong, M. Zheng, J. Wu, C. Cui, K. W. Y. Chan, C. Xu, T. H. Chen. (2024). On-Site Melanoma Diagnosis Utilizing a Swellable Microneedle-Assisted Skin Interstitial Fluid Sampling and a Microfluidic Particle Dam for Visual Quantification of S100A1. Adv. Sci., 11:2306188.
doi: 10.1002/advs.202306188

Microfluidic particle counter visualizing mucosal antibodies against SARS-CoV-2 in the upper respiratory tract for rapid evaluation of immune protection

J. Li, L. T. Chu, H. Hartanto, G. Guo, L. Liu, J. Wu, M. Wu, C. Cui, G. Wang, W. Liu, H. K. Kwong, S. Wu, T. H. Chen (2024). Microfluidic particle counter visualizing mucosal antibodies against SARS-CoV-2 in the upper respiratory tract for rapid evaluation of immune protection. Lab on a Chip, 24:2658-2668.
doi: 10.1039/D4LC00118D

Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs

R. Xiao, J. Li, Y. F. Wong, L. T. Chu, Y. Zhu, L. Wang, M. Wu, D. Zhang, M. Gong, J. Lai, K. W. Y. Chan, R. Fan, T. H. Chen, Y. Lu. (2024). Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs. Commun. Eng., 3:40.
doi: 10.1038/s44172-024-00185-5

Construction of a Decellularized Multicomponent Extracellular Matrix Interpenetrating Network Scaffold by Gelatin Microporous Hydrogel 3D Cell Culture System

J. Shi, H. Yao, B. Wang, J. Yang, D. Liu, X. Shang, H. Chong, W. Fei, D.-A. Wang (2024). Construction of a Decellularized Multicomponent Extracellular Matrix Interpenetrating Network Scaffold by Gelatin Microporous Hydrogel 3D Cell Culture System. Macromol. Rapid Commun., 45:2300508.
doi: 10.1002/marc.202300508

An engineered lymph node comprising porous collagen scaffold with hybridized biological signals embedded in B cell membrane coatings

B. Liu, M. Jin, C. Ma, Z. Zhang, L. Ma, Y. Zhang, D.-A. Wang (2024). An engineered lymph node comprising porous collagen scaffold with hybridized biological signals embedded in B cell membrane coatings. Biomaterials, 304:122420.
doi: 10.1016/j.biomaterials.2023.122420

Rejuvenating Hyaline Cartilaginous Phenotype of Dedifferentiated Chondrocytes in Collagen II Scaffolds: A Mechanism Study Using Chondrocyte Membrane Nanoaggregates as Antagonists

H. Zhou, Y. Mu, C. Ma, Z. Zhang, C. Tao, D.-A. Wang (2024). Rejuvenating Hyaline Cartilaginous Phenotype of Dedifferentiated Chondrocytes in Collagen II Scaffolds: A Mechanism Study Using Chondrocyte Membrane Nanoaggregates as Antagonists. ACS Nano, 18(3):2077-2090.
doi: 10.1021/acsnano.3c09033

Type II collagen scaffolds repair critical-sized osteochondral defects under induced conditions of osteoarthritis in rat knee joints via inhibiting TGF-β-Smad1/5/8 signaling pathway

X. Hu, M. Jin, K. Sun, Z. Zhang, Z. Wu, J. Shi, P. Liu, H. Yao, D.-A. Wang (2024). Type II collagen scaffolds repair critical-sized osteochondral defects under induced conditions of osteoarthritis in rat knee joints via inhibiting TGF-β-Smad1/5/8 signaling pathway. Bioactive Materials, 35:416-428.
doi: 10.1016/j.bioactmat.2024.02.008

Harnessing Nanomedicine for Cartilage Repair: Design Considerations and Recent Advances in Biomaterials

H. Zhou, Z. Zhang, Y. Mu, H. Yao, Y. Zhang, D.-A. Wang (2024). Harnessing Nanomedicine for Cartilage Repair: Design Considerations and Recent Advances in Biomaterials. ACS Nano, 18(16):10667-10687.
doi: 10.1021/acsnano.4c00780

Chrom-seq identifies RNAs at chromatin marks

L. Fan, W. Sun, Y. Lyu, F. Ju, W. Sun, J. Chen, H. Ma, S. Yang, X. Zhou, N. Wu, W. Yi, E. Chen, R. Villaseñor, T. Baubec, J. Yan (2024). Chrom-seq identifies RNAs at chromatin marks. Science Advances, 10(31):eadn1397.
doi: 10.1126/sciadv.adn1397

Automatic high-throughput and non-invasive selection of sperm at the biochemical level

Y. Mu, X. Zhou, L. Li, X. Liu, X. Wen, L. Zhang, B. Yan, W. Zhang, K. Dong, H. Hu, Y. Liao, Z. Ye, A. Deng, Y. Wang, Z. Mao, M. Yang, X. Xiao (2024). Automatic high-throughput and non-invasive selection of sperm at the biochemical level. Med, 5(6):603-621.e7.
doi: 10.1016/j.medj.2024.03.008

An integrated and multi-functional droplet-based microfluidic platform for digital DNA amplification

Y. Wang, X. Zhou, Z. Yang, T. Xu, H. Fu, C.-C. Fong, J. Sun, Y. R. Chin, L. Zhang, X. Guan, M. Yang (2024). An integrated and multi-functional droplet-based microfluidic platform for digital DNA amplification. Biosensors and Bioelectronics, 246:115831.
doi: 10.1016/j.bios.2023.115831

Distinguishing High-Metastasis-Potential Circulating Tumor Cells through Fluidic Shear Stress in a Bloodstream-Like Microfluidic Circulatory System

M. Yang, W. Li, Z. Guo, Z. Zhou, Z. Zhou, H. He, J. Sun, X. Zhou, Y. R. Chin, L. Zhang (2024). Distinguishing High-Metastasis-Potential Circulating Tumor Cells through Fluidic Shear Stress in a Bloodstream-Like Microfluidic Circulatory System. Oncogene, Preprint.
doi: 10.21203/rs.3.rs-3790276/v1

Cellulose Nanofibrils of High Immunoaffinity for Efficient Enrichment of Small Extracellular Vesicles

Z. Wang, J. Dai, H. He, T. Si, K. Ng, S. Zheng, X. Zhou, Z. Zhou, H. Yuan, M. Yang (2024). Cellulose Nanofibrils of High Immunoaffinity for Efficient Enrichment of Small Extracellular Vesicles. Small Methods, 2400426.
doi: 10.1002/smtd.202400426

High Performance Supramolecular Organogel Adhesives for Antimicrobial Applications in Diverse Conditions

G. Lu, C. Chen, Z. Wang, et al. (2023). High Performance Supramolecular Organogel Adhesives for Antimicrobial Applications in Diverse Conditions. ACS Applied Materials & Interfaces, 15(37):44194–44204.
doi: 10.1021/acsami.3c07295

Near-Infrared-Activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner

Z. Deng, H. Li, S. Chen, et al. (2023). Near-Infrared-Activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner. Nature Chemistry, 15:930–939.
doi: 10.1038/s41557-023-01242-w

Secreted LRPAP1 as a ligand binds and induces IFNAR1 degradation to facilitate virus evasion from innate immunity

H. Li, X. Wang, Y. Wang, et al. (2023). Secreted LRPAP1 as a ligand binds and induces IFNAR1 degradation to facilitate virus evasion from innate immunity. Signal Transduction and Targeted Therapy, 8:374.
doi: 10.1038/s41392-023-01630-1

Single-Cell Secretion Analysis via Microfluidic Cell Membrane Immunosorbent Assay for Immune Profiling

Y. Xu, K. C. Wu, W. Jiang, et al. (2023) Single-Cell Secretion Analysis via Microfluidic Cell Membrane Immunosorbent Assay for Immune Profiling. Analytical Chemistry, 96(1):49–58
doi: 10.1021/acs.analchem.3c02562

High Throughput Confined Migration Microfluidic Device for Drug Screening

Z. H. Yang, Z. H. Zhou, T. X. Si, et al. (2023). High Throughput Confined Migration Microfluidic Device for Drug Screening. Small, 19(16):2207194.
doi: 10.1002/smll.202207194

Intracellular and extracellular ion variation measurement in alpha(α)-particle irradiated cells using t-FROZEN! and laser-induced breakdown spectroscopy

A-M. O. Ilyas, J-D. Musah, R. Ahmed, et al. (2023). Intracellular and extracellular ion variation measurement in alpha(α)-particle irradiated cells using t-FROZEN! and laser-induced breakdown spectroscopy. Results in Optics, 11:100388.
doi: 10.1016/j.rio.2023.100388

Comparative Analysis of Transcriptome and Proteome Revealed the Common Metabolic Pathways Induced by Prevalent ESBL Plasmids in Escherichia coli

C. Huang, H. Pham, L. Zhu, et al. (2023). Comparative Analysis of Transcriptome and Proteome Revealed the Common Metabolic Pathways Induced by Prevalent ESBL Plasmids in Escherichia coli. International Journal of Molecular Sciences, 24(18):14009.
doi: 10.3390/ijms241814009

Hypertonicity induces mitochondrial extracellular vesicles (MEVs) that activate TNF-α and β-catenin signaling to promote adipocyte dedifferentiation

G. Liu, Y. Wang, Y. Pan, et al. (2023). Hypertonicity induces mitochondrial extracellular vesicles (MEVs) that activate TNF-α and β-catenin signaling to promote adipocyte dedifferentiation. Stem Cell Research & Therapy, 14:333.
doi: 10.1186/s13287-023-03558-3

Wnt3a signaling with serum supply induces replication stress in cultured cells

Y. Wang, R. Wang, H. Ma, et al. (2023). Wnt3a signaling with serum supply induces replication stress in cultured cells. Biochemistry and Biophysics Reports, 35:101499.
doi: 10.1016/j.bbrep.2023.101499

Core-Shell Droplet-Based Angiogenic Patches for the Treatment of Ischemic Diseases: Ultrafast Processability, Physical Tunability, and Controlled Delivery of an Angiogenic Cocktail

T. V. A. Bui, J. J. Kim, X. Huang, et al. (2023). Core-Shell Droplet-Based Angiogenic Patches for the Treatment of Ischemic Diseases: Ultrafast Processability, Physical Tunability, and Controlled Delivery of an Angiogenic Cocktail. ACS Applied Materials & Interfaces, 15(44):50693–50707.
doi: 10.1021/acsami.3c09062

Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemia

J. J. Kim, J. H. Park, H. Kim, et al. (2023). Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemia. Experimental & Molecular Medicine, 55:2248–2259.
doi: 10.1038/s12276-023-01096-9

The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health

T. V. A. Bui, H. Hwangbo, Y. Lai, et al. (2023). The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health. Korean Circulation Journal, 53(8):499–518.
doi: 10.4070/kcj.2023.0048

ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis

C. Yin, C. Zhang, Y. Wang, et al. (2023). ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis. Hepatology, 10.1097/HEP.0000000000000704.
doi: 10.1097/HEP.0000000000000704

Populational pan-ethnic screening panel enabled by deep whole genome sequencing

L. Yang, Z. Lin, Y. Gao, et al. (2023). Populational pan-ethnic screening panel enabled by deep whole genome sequencing. NPJ Genomic Medicine, 8:38.
doi: 10.1038/s41525-023-00383-8

Regulatory T cell intravitreal delivery using hyaluronan methyl cellulose hydrogel improves therapeutic efficacy in experimental autoimmune uveitis

T. Zhang, X. Han, Y. Zhang, et al. (2023). Regulatory T cell intravitreal delivery using hyaluronan methyl cellulose hydrogel improves therapeutic efficacy in experimental autoimmune uveitis. Biomaterials Advances, 151:213496.
doi: 10.1016/j.bioadv.2023.213496

Evaluation of exogenous therapeutic protein activity under confinement and crowding effects

J. Dai, Z. Peng, S. Shen, et al. (2023) Evaluation of exogenous therapeutic protein activity under confinement and crowding effects. Nanoscale, 15(32):13450–13458
doi: 10.1039/D3NR02968A

Nanopore sequencing identifies differentially methylated genes in the central nervous system in experimental autoimmune encephalomyelitis

S. W., Y. Ni, Q. Jiang, L. Tan, O. Sparagano, R. Li, G. Yan (2023). Nanopore sequencing identifies differentially methylated genes in the central nervous system in experimental autoimmune encephalomyelitis. J. Neuroimmunol., 381:578134.
doi: 10.1016/j.jneuroim.2023.578134

Unraveling the whole genome DNA methylation profile of zebrafish kidney marrow by Oxford Nanopore sequencing

X. Liu, Y. Ni, D. Wang, S. Ye, M. Yang, X. Sun, A. Y. H. Leung, R. Li. (2023). Unraveling the whole genome DNA methylation profile of zebrafish kidney marrow by Oxford Nanopore sequencing. Scientific Data, 10:532.
doi: 10.1038/s41597-023-02431-5

Scalable pattern formation of skeletal myotubes by synergizing microtopographic cues and chiral nematics of cells

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Bioorthogonal Conjugation-Assisted Purification Method for Profiling Cell Surface Proteome

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Sensitivity schemes for dynamic glucose-enhanced magnetic resonance imaging to detect glucose uptake and clearance in mouse brain at 3 T

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Last modified: 2024.12.05