Explore our cutting-edge projects, generously funded by The Tung Foundation, alongside pioneering external research led by our dedicated principal investigators – all driving biomedical innovation forward.
Research Projects Funded by the Centre
- Project
- Principal Investigator
- Investigation of Therapeutic Potential of Exosomes Derived from hiPSCs for Treating Hair Loss Patients
(hiPSC 衍生的外泌體治療脫髮患者的潛力研究) - Prof. Kiwon Ban
Co-I: Prof. Gigi Lo
- CEST MRI for assessing molecular abnormalities in aging brain
(化學交換飽和轉移磁⼒共振成像⽤於評估老化⼤腦的分⼦異常) - Prof. Kannie Chan
Co-I: Prof. Youngjin Lee, Prof. Huiyong Yin, Prof. Xiangyu Zhao (SDSC)
- Automated Droplet Screen System for Rapid Single-Cell Immune Response Assessment
(自動化滴液系統用於高通量單細胞免疫反應篩選) - Prof. Chia-Hung Chen
Co-I: Prof. Liang Zhang
- Lab on a patch: a skin patch for rapid screening of malignant melanoma based on microneedles and structurally programmed microfluidic particle dam
(實驗室貼片：整合微針與結構程序化微流粒子壩以實現快速篩檢惡性黑色素細胞癌的皮膚貼片) - Prof. Cecil Chen
Co-I: Prof. Yang Lu (HKU)
- Building AI-enabled cancer diagnostic model with ligand-receptor interaction biomarkers through spatial transcriptome
(建構基於空間轉錄組的配體-受體互作生物標記的人工智能癌症診斷模型) - Prof. Lingxi Chen
Co-I: Prof. Mengsu (Michael) Yang
- Regulation of brain metastatic colonization of triple-negative breast cancer by novel genes
(新基因調控三陰性乳癌腦轉移定植) - Prof. Rebecca Chin
Co-I: Prof. Gigi Lo
- Elucidating the Mechanisms and Therapeutic Potential of Photodynamic Therapy in Wound Healing
(光動力療法在傷口癒合中的效果與機制) - Prof. Kwan T. Chow
Co-I: Prof. Gigi Lo
- Genome-wide characterization of virulence-related and antibiotic-resistance related hypothetical proteins in Pseudomonas aeruginosa
(銅綠假單胞菌毒力相關和抗生素耐藥性相關假設蛋白的全基因組特徵) - Prof. Xin Deng
Co-I: Prof. Jian Yan
- Microfluidic Inflammatory Tumor Model for High Throughput Drug Screening
(微流控炎性腫瘤模型用於高通量藥物篩選) - Prof. Bee Luan Khoo
Co-I: Prof. Terrence Lau
- Establishment of Inflammatory Tumors in A Mouse Model for The Evaluation of Tumor Progression
(建立小鼠模型中的炎性腫瘤用於評估腫瘤進展) - Prof. Bee Luan Khoo
Co-I: Prof. Kwan T. Chow
- Understanding how sleep disturbance affects clock functions in the hippocampus and its consequences
(探究睡眠障礙對海馬體生物鐘功能的影響及其後果) - Prof. Jin Young Kim
Co-I: Prof. Liang Zhang
- Natural herb compounds for prevention of skin ageing
(植物天然分子抗皮膚衰老的研究) - Prof. Mingliang He
Co-I: Prof. Lin Zhu (HKBU)
- Development of Outer Membrane Vesicles as Delivery carriers for Cancer Treatment
(開發外膜囊泡作為癌症治療的傳遞載體) - Prof. Terrence Lau
Co-I: Prof. Bee Luan Khoo
- A 3D perineural invasion model on chip for investigating the interaction between Schwann cells and macrophages
(基于 DMF 構建 3D 神經周圍侵襲模型以研究雪旺細胞和巨噬細胞的相互作用) - Prof. Youngjin Lee
Co-I: Prof. Mengsu (Michael) Yang
- Using DNA methylation for acute myeloid leukemia subtyping
(使用 DNA 甲基化作為急性髓性白血病分型的分子標記物) - Prof. Runsheng Li
Co-I: Prof. Liang Zhang
- Development of Novel Molecular- and Nano-sensitizers for Sonodynamic Therapy
(用於聲動力療法的新型分子和奈米敏化劑的開發) - Prof. Gigi Lo
Co-I: Prof. Kwan T. Chow
- Development of Targeted Tumor-Mimicking Nanoparticles for Chemotherapeutic Drug Delivery and Modulation of the Glioblastoma Immune Microenvironment
(開發具有靶向性的仿腫瘤納米粒子以遞送化療藥物並調節膠質母細胞瘤免疫微環境) - Prof. Dongan Wang
Co-I: Prof. Zongli Zheng
- To develop a lipid nanoparticle (LNP)-mRNA vector-based antiglaucoma gene editing therapy
(針對青光眼的脂質納米體 mRNA 載體基因編輯療法) - Prof. Wenjun Xiong
Co-I: Prof. Zongli Zheng
- Identification of Noncoding RNA Driving Epigenetic Changes During Cellular Senescence
(鑑定透過表觀遺傳調控驅動細胞衰老的非編碼核糖核酸) - Prof. Jian Yan
Co-I: Prof. Jilin Zhang
- Single-Cell Metabolomics: Towards Applications in Cancer and Aging
(單細胞代謝組學技術及在癌症與衰老方面的應用) - Prof. Huiyong Yin
Co-I: Prof. Mengsu (Michael) Yang, Prof. Liang Zhang
- Develop a medical diagnostic approach based on the altered RNA-RBP binding dynamics
(開發基於 RNA 與 RNA 結合蛋白動態變化的醫療診斷策略) - Prof. Jilin Zhang
Co-I: Prof. Jian Yan, Prof. Xin Deng, Prof. Bing Fu (CityUHK BME)
- A Single-cell Platform to Investigate the Metabolism of NK and Cancer Cells in CAR-NK Therapy
(單細胞平臺監測 CAR-NK 細胞療法過程中NK與腫瘤細胞的代謝水平) - Prof. Liang Zhang
Co-I: Prof. Xiaoyu Zhou (CityUHK BMS)
- Develop chemical biology tools to dissect SIRT3 functions and mitochondrial homeostasis of cancer cells
(開發解析 SIRT3 功能和癌細胞線粒體穩態的化學生物學工具) - Prof. Liang Zhang
Co-I: Prof. Hongyan Sun (CityUHK CHEM)
- High-fidelity microscopy investigations of eye diseases
(前沿光學顯微成像技術在眼部疾病研究中的應用) - Prof. Qinrong Zhang
Co-I: Prof. Wenjun Xiong
- Tumor content in circulation for monitoring of lung cancer
(循環血液中腫瘤 DNA 含量用於監測肺癌) - Prof. Zongli Zheng
Co-I: Prof. Mengsu (Michael) Yang
- Project
- Principal Investigator
- Development of an effective method to obtain functional dermal papilla cells for hair regeneration
(開發穫得用於毛髮再生的功能性真皮乳頭細胞的有效方法) - Prof. Kiwon Ban
- Develop imaging biomarkers for assessing glymphatic dysfunction in neurodegenerative diseases
(開發用於評估神經退化性疾病中的淋巴功能障礙的成像生物標誌物) - Prof. Kannie Chan
- Regulation of novel breast cancer genes by PI3K/Akt pathway
(PI3K/Akt 通路調控新型乳腺癌基因) - Prof. Rebecca Chin
- Immunosuppressive mechanism of hepatocellular carcinoma
(肝細胞癌的免疫抑制機制) - Prof. Kwan T. Chow
- Characterization of key regulators of Pseudomonas aeruginosa virulence
(呼吸道病原細菌毒力關鍵調控因子的研究) - Prof. Xin Deng
- Mechanism study: how circadian clocks mediate intercellular communications in brain pathologies to enhance brain repair systems
(機制研究：晝夜節律鐘在腦病中介導細胞間通訊以增強神經修復系統) - Prof. Jinyoung Kim
- Development of novel strategy for preventing hearts disease by oral treatment with special probiotics secreting short chain fatty acids
(開發用分泌短鏈脂肪酸的特殊益生菌口服治療預防心臟病的新策略) - Prof. Terrence Lau
- Research on Neuron-glia Interactions in the Discovery of Novel Theranostic Exosomal Targets of Alzheimer’s Disease (AD)
(關於研究腦神經元與膠質細胞之相互作用及探索其應用於阿茲海默症的外泌體生物治療診斷標記) - Prof. Youngjin Lee
- Exploration of Advanced Photosensitizers for Switchable Photodynamic and Photothermal Therapy
(用於可切換光動力和光熱治療的先進光敏劑的探索) - Prof. Gigi Lo
- To develop an infrared light-inducible lipid nanoparticle (LNP)-based mRNA gene therapy vector
(研製一個紅線光控制的脂質納米體 mRNA 基因治療載體) - Prof. Wenjun Xiong
- Identification of noncoding RNAs that are essential for epigenetic modifications for cancer treatment
(鑑定對表觀遺傳修飾至關重要並有癌症治療潛力的非編碼 RNA) - Prof. Jian Yan
- Highly efficient isolation of short-length cell free DNA with nanowires
(納米線高效分離短片段血漿游離 DNA) - Prof. Mengsu (Michael) Yang
- Define the isoform-specific substates of protein kinase MEK1 and MEK2
(蛋白激酶 MEK1 和 MEK2 異構體特異底物的研究) - Prof. Liang Zhang
- Project
- Principal Investigator
- Development of novel method to generate mature cardiomyocytes derived from human pluripotent stem cells
(開發誘導血管再生的策略) - Prof. Kiwon Ban
- Development of neuroimaging biomarkers for predicting neurological disorders
(開發神經影像生物標記物以預測神經系統疾病) - Prof. Kannie Chan
- Development of 3D organoid models for identifying novel breast cancer therapeutics targeting tumor microenvironment and cancer stem cells
(開發 3D 器官模型鑑定針對腫瘤微環境的新型乳腺癌藥物) - Prof. Rebecca Chin
- TLR agonists as plasmacytoid dendritic cell-based cancer immunotherapy
(TLR 激動劑作為基於漿細胞樣樹突狀細胞的癌症免疫療法) - Prof. Kwan T. Chow
- Neural cell networking mediated by circadian clocks to enhance brain repair systems
(晝夜節律鐘介導的神經細胞網路促進大腦修復系統) - Prof. Jin Young Kim
- Delivery of sRNA to target drug resistant bacteria
(應對抗生素耐藥性問題的策略) - Prof. Terrence Lau
- Research on neuron-glia interactions in the discovery of novel theranostic exosomal targets of Alzheimer's disease (AD)
(關於研究腦神經元與膠質細胞之相互作用及探索其應用於阿茲海默症的外泌體生物治療診斷標記) - Prof. Youngjin Lee
- Development of coordination-driven supramolecular nanoplatforms for theranostic applications
(配位驅動超分子納米平臺在治療學領域的應用) - Prof. Gigi Lo
- Ex vivo hematopoietic stem cells gene therapy against thalassemia
(地中海貧血的體外造血幹細胞基因療法開發) - Prof. Jiahai Shi
- Integrative analysis of multi-omics and histopathology images to establish a classification system for esophageal squamous cell carcinoma
(整合多組學和組織病理學圖像建立食管鱗癌分類系統) - Prof. Xin Wang
- Developing gene editing therapy for inherited retinal diseases
(開發遺傳性致盲視網膜疾病的基因編輯治療) - Prof. Wenjun Xiong
- Exploring the molecular mechanisms of HERV-H in mediating chromatin high-order structure in human embryonic stem cells
(研究 HERV-H 在胚胎幹細胞染色質高級結構調控中的分子機制) - Prof. Jian Yan
- A home-based nucleic acid test platform for rapid detection of COVID-19 virus and other pathogens
(等溫核酸橫向流動分析法快速檢測 SARS-CoV-2 病毒) - Prof. Mengsu (Michael) Yang
- Screen for molecular targets in the senescence response of tumor cells to chemotherapy
(化療導致腫瘤細胞衰老反應的分子靶標篩選) - Prof. Liang Zhang
External Research Projects
