Prof. Chen received his veterinary degree in 1997 and a Master of Preventive Veterinary Medicine degree in 2000, both from the China Agriculture University. He completed his PhD in Food Microbiology at the University of Maryland, USA, in 2004, and his postdoctoral training in the Department of Microbiology and Molecular Genetics at the Medical College of Wisconsin, USA, in 2009. Before joining City University of Hong Kong in 2019, he had spent 10 years working in the Department of Applied Biology and Chemical Technology at the Hong Kong Polytechnic University as Assistant Professor, Associate Professor and Professor.
Prof. Chen participates in the Hong Kong government’s policy making through an ad-hoc working group on microbial guidelines for ready-to-eat food under the Department of Food and Environmental Hygiene of Hong Kong Government. He is also a member of the Shenzhen Expert Committee to help the Shenzhen government’s decision making on the development of biotechnologies. He has established and served as the Director of the Shenzhen Key Laboratory for Food Biological Safety Control before joining CityU.
Prof. Chen’s current research covers research on bacterial antimicrobial resistance, virulence and tolerance in the veterinary, food and medical microbiology fields. His research lies on the interface of clinical study and basic science using multi-disciplinary approaches including Genomics, Genetics, Biochemistry, Cell Biology and Chemical Biology with the ultimate goal of developing novel therapies to combat bacterial antimicrobial resistance.
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Representative publications |
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After joining to CityU |
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Yang G*, Xu Q, Chen S*. Neutrophil function in hypervirulent Klebsiella pneumoniae infection. The Lancet Microbes. January 28, 2022; DOI: 10.1016/S2666-5247(22)00004-0. |
86.208 |
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Hu Y, Wang J, Chen S, Li Y, Zhang R, Chen S*. Non-typhoidal salmonella invasive infections in China. Lancet Infect Dis. 2022 Jul;22(7):939. doi: 10.1016/S1473-3099(22)00347-4. |
71.421 |
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Liu C, Dong N, Chan EWC, Chen S, Zhang R. Molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in China, 2016-20. The Lancet Infectious Diseases. 2022 Feb;22(2):167-168. DOI: 10.1016/S1473-3099(22)00009-3. |
71.421 |
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Sun Q, Yang X, Huang Y, Li Y, Lin J, He D, Liu C, Chen S*, Zhang R*. Risk factors and clinical impact associated with infections caused by different types of carbapenem-resistant Klebsiella pneumoniae in China: A clinical study from 2014 to 2017. J Infect. 2022 Jun 18:S0163-4453(22)00364-4. doi: 10.1016/j.jinf.2022.05.045. |
38.637 |
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Ni H, Chan KW, Cheng Q, Chen K, Xie M, Wang H, Chan WC, Chen S*. A novel clinical therapy to combat infections caused by Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae. J Infection. 2022-05. DOI: 10.1016/j.jinf.2022.05.004. |
38.637 |
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Yang X., Wai-Chi Chan E., Zhang R., Chen S*. (2019). A conjugative plasmid that augments virulence in Klebsiella pneumoniae. Nature Microbiology. https://doi.org/10.1038/s41564-019-0566-7 |
30.964 |
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Liu C, Chen K, Wu Y, Huang L, Fang Y, Lu J, Zeng Y, Xie M, Chi Chan EW, Chen S*, Zhang R*. Epidemiological and Genetic Characteristics of Clinical Carbapenem-Resistant Acinetobacter baumannii Strains Collected Countrywide from Hospital Intensive Care Units (ICUs) in China. Emerg Microbes Infect. 2022 Jun 22:1-45. doi: 10.1080/22221751.2022.2093134. |
19.568 |
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Xie M, Chen K, Chan EW, Chen S*. Identification and genetic characterization of two conjugative plasmids that confer azithromycin resistance in Salmonella. Emerg Microbes Infect. 2022 Dec;11(1):1049-1057. doi: 10.1080/22221751.2022.2058420. |
19.568 |
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Yang X, Sun Q, Li J, Jiang Y, Li Y, Lin J, Chen K, Chan EW, Zhang R, Chen S. Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae in China. Emerg Microbes Infect. 2022 Dec;11(1):841-849. doi: 10.1080/22221751.2022.2049458. |
19.568 |
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Yang X, Dong N, Chan EW, Chen S*. Genetic cluster analysis of SARS-CoV-2 and the identification of those responsible for the major outbreaks in various countries. Emerg Microbes Infect. 2020 Dec;9(1):1287-1299. DOI: 10.1080/22221751.2020.1773745. |
19.568 |
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Huang H, Dong N, Shu L, Lu J, Sun Q, Chan EW, Chen S*, Zhang R*. Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014-2019. Emerg Microbes Infect. 2020 Jan 29;9(1):237-245. DOI: 10.1080/22221751.2020.1717380. eCollection 2020. |
19.568 |
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Wei R, Yang X, Liu H, Wei T, Chen S*, Li X*. Synthetic Pseudaminic-Acid-Based Antibacterial Vaccine Confers Effective Protection against Acinetobacter baumannii Infection. ACS Centr. Sci. 2021 Sep 22;7(9):1535-1542. DOI: 10.1021/acscentsci.1c00656. |
18.728 |
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Yang, X., Dong, N., Chan, E. W., Zhang, R. & Chen, S*., Carbapenem Resistance-Encoding and Virulence-Encoding Conjugative Plasmids in Klebsiella pneumoniae. 21 May 2020, Trends in Microbiology. 29, 1, p. 65-83 |
18.230 |
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Zhang R, Dong N, Shen ZQ, Zeng Y, Lu JY, Liu CC, Zhou HW, Hu YY, Sun QL, Cheng QP, Shu LB, Cai JC, Chan EWC, Chen GX, Chen S*. Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X). Nature Communications. 2020, Sep 16;11(1):4648 |
17.694 |
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Sun, Z., Shang, Z., Forelli, N., Po, K. H. L., Chen, S., Brady, S. F. & Li, X., Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation Mediated Cyclization and Absolute Structure Establishment. 29 Jul 2020, Angewandte Chemie-International Edition. 59, 45, p. 19868–19872 |
16.823 |
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Wang J, Lin D, Liu M, Liu H, Blasco P, Sun Z, Cheung YC, Chen S, Li X. Total Synthesis of Mannopeptimycin β via β-Hydroxyenduracididine Ligation. J Am Chem Soc. 2021 Aug 5. doi: 10.1021/jacs.1c05922. |
16.383 |
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Xie M, Chen K, Chan EW, Zhang R*, Chen S*. Characterization of clinical carbapenem-resistant K1 Klebsiella quasipneumoniae subsp. similipneumoniae strains harboring virulence plasmid. Int J Antimicrob Agents. 2022 Jun 24:106628. doi: 10.1016/j.ijantimicag.2022.106628. |
15.441 |
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Cheng Q, Cheung YC, Chan EWC, Wong KY, Chen S*. Unveiling the evolution routes of TEM-type extended-spectrum β-lactamases. Int J Antimicrob Agents. 2022 Jan;59(1):106498. doi: 10.1016/j.ijantimicag.2021.106498. |
15.441 |
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Li, R., Xie, M., Liu, L., Huang, Y., Wu, X., Wang, Z., Chan, E. W. C. Chen S*. Characterisation of a cointegrate plasmid harbouring blaNDM-1 in a clinical Salmonella Lomita strain. Jan 2020, Int J Antimicrob Agents. 55, 1, 105817. |
15.441 |
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Qiu, J., Nie, Y., Zhao, Y., Zhang, Y., Li, L., Wang, R., Wang, M., Chen, S., Wang, J., Li, Y. & Xia, J., Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism. 10 Mar 2020, Proceedings of the National Academy of Sciences of the United States of America. 117, 10, p. 5260-5268 |
12.779 |
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Dong N, Yang X, Chan EW, Zhang R, Chen S*. Klebsiella species: Taxonomy, hypervirulence and multidrug resistance. eBioMedicine. 2022 May;79:103998. doi: 10.1016/j.ebiom.2022.103998. |
11.205 |
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Dong N, Zeng Y, Cai C, Sun C, Lu J, Liu C, Zhou H, Sun Q, Shu L, Wang H, Wang Y, Wang S, Wu C, Chan EW, Chen G, Shen Z, Chen S*, Zhang R*. Prevalence, transmission, and molecular epidemiology of tet(X)-positive bacteria among humans, animals, and environmental niches in China: An epidemiological, and genomic-based study. Sci Total Environ. 2022 Apr 20;818:151767. doi: 10.1016/j.scitotenv.2021.151767. |
10.753 |
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Hou, C., Xu, C., Yi, B., Huang, X., Cao, C., Lee, Y., Chen, S*. & Yao X*. Mechano-Induced Assembly of a Nanocomposite for “Press-N-Go” Coatings with Highly Efficient Surface Disinfection. 28 Apr 2021, ACS Applied Materials and Interfaces. 13, 16, p. 19332–19341 10 p. |
10.383 |
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Lin, D., Chen, K., Guo, J., Ye, L., Li, R., Chan, E. W. C. & Chen, S*., Contribution of biofilm formation genetic locus, pgaABCD, to antibiotic resistance development in gut microbiome. Nov 2020, Gut Microbes. 12, 1, p. 1-12 12 p. |
9.434 |
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Before joining to CityU |
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White D.G., Zhao S., Sudler R., Ayers S., Friedman S., Chen S., McDermott P.F., McDermott S., Wagner D.D., Meng J. (2001). The isolation of antibiotic-resistant salmonella from retail ground meats. New England Journal of Medicine, v.345, n.16, p.1147-1154. |
176.079 |
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Gu D., Dong N., Zheng Z., Lin D., Huang M., Wang L., Chan E.W.-C., Shu L., Yu J., Zhang R., Chen S*. (2018). A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. The Lancet Infectious Diseases, v.18, n.1, p.37-46. https://doi.org/10.1016/S1473-3099(17)30489-9 |
71.421 |
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Wong M.H.Y., Shum H.-P., Chen J.H.K., Man M.-Y., Wu A., Chan E.W.-C., Yuen K.-Y., Chen S*. (2018). Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae. The Lancet Infectious Diseases, v.18, n.1, p.24. https://doi.org/10.1016/S1473-3099(17)30629-1 |
71.421 |
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Yao H., Qin S., Chen S., Shen J., Du X.-D. (2018). Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae. The Lancet Infectious Diseases, v.18, n.1, p.25. https://doi.org/10.1016/S1473-3099(17)30628-X |
71.421 |
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Zhang R., Chan E.W.-C., Zhou H., Chen S*. (2017). Prevalence and genetic characteristics of carbapenem-resistant Enterobacteriaceae strains in China. The Lancet Infectious Diseases, v.17, n.3, p.256-257. https://doi.org/10.1016/S1473-3099(17)30072-5 |
71.421 |
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Zhang R., Huang Y., Chan E.W.C., Zhou H., Chen S*. (2016). Dissemination of the mcr-1 colistin resistance gene. The Lancet Infectious Diseases, v.16, n.3, p.291-292. https://doi.org/10.1016/S1473-3099(16)00062-1 |
71.421 |
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Liu X, Geng S, Chan EW, Chen S*. Increased prevalence of Escherichia coli strains from food carrying bla NDM and mcr-1-bearing plasmids that structurally resemble those of clinical strains, China, 2015 to 2017. Euro Surveill. 2019 Mar;24(13). DOI: 10.2807/1560-7917.ES.2019.24.13.1800113 |
21.286 |
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Chen K, Chan EW, Xie M, Ye L, Dong N, Chen S*. Widespread distribution of mcr-1-bearing bacteria in the ecosystem. Euro Surveill. 2017 Sep;22(39). DOI: 10.2807/1560-7917.ES.2017.22.39.17-00206 |
21.286 |
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Chen K, Dong N, Chan EW, Chen S*. Transmission of ciprofloxacin resistance in Salmonella mediated by a novel type of conjugative helper plasmids. Emerg Microbes Infect. 2019;8(1):857-865. DOI: 10.1080/22221751.2019.1626197 |
19.568 |
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Chen K, Chan EWC, Chen S*. Evolution and transmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance in Salmonella. Emerg Microbes Infect. 2019;8(1):396-403. DOI: 10.1080/22221751.2019.1585965 |
19.568 |
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Dong N, Yang XM, Zhang R, Chan EWC, Chen S*. Tracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strains. Emerg Microbes Infect. 2018 Aug 12;7(1):146. DOI: 10.1038/s41426-018-0146-6 |
19.568 |
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Dong N, Yang XM, Zhang R, Chan EWC, Chen S*. Tracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strains. Emerg Microbes Infect. 2018 Aug 12;7(1):146. DOI: 10.1038/s41426-018-0146-6 |
19.568 |
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Jin K., Sam I.H., Po K.H.L., Lin D., Ghazvini Zadeh E.H., Chen S*., Yuan Y*., Li X*. (2016). Total synthesis of teixobactin. Nature Communications, v.7. https://doi.org/10.1038/ncomms12394 |
17.694 |
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Li R., Xie M., Chan E.W.C., Chen S. * (2018). Rapid resolution of multi-drug resistance bacterial genome harbouring mcr-1 and blaCMY-2 using MinION sequencing platform. Int J Antimicrob Agents., v.52, n.2, p.303-304. https://doi.org/10.1016/j.ijantimicag.2018.05.011 |
15.441 |
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Li R., Yu H., Xie M., Chen K., Dong N., Lin D., Chan E.W.-C., Chen S*. (2018). Genetic basis of chromosomally-encoded mcr-1 gene. Int J Antimicrob Agents., v.51, n.4, p.578-585. https://doi.org/10.1016/j.ijantimicag.2017.11.015 |
15.441 |
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Li R., Chan E.W.-C., Chen S*. (2016). Characterisation of a chromosomally-encoded extended-spectrum β-lactamase gene blaPER-3 in Aeromonas caviae of chicken origin. Int J Antimicrob Agents., v.47, n.1, p.103-105. https://doi.org/10.1016/j.ijantimicag.2015.10.018 |
15.441 |
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Po K.H.L., Wong M.H.Y., Chen S*. (2015). Identification and characterisation of a novel plasmid-mediated quinolone resistance gene, qnrVC7, in Vibrio cholerae of seafood origin. Int J Antimicrob Agents., v.45, n.6, p.667-668. https://doi.org/10.1016/j.ijantimicag.2015.02.002 |
15.441 |
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Liu M., Wong M.H.Y., Chen S*. (2013). Molecular characterisation of a multidrug resistance conjugative plasmid from Vibrio parahaemolyticus. Int J Antimicrob Agents., v.42, n.6, p.575-579. https://doi.org/10.1016/j.ijantimicag.2013.08.014 |
15.441 |
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Liu M., Wong M.H.Y., Chen S*. (2013). Mechanisms of fluoroquinolone resistance in Vibrio parahaemolyticus. Int J Antimicrob Agents., v.42, n.2, p.187-188. https://doi.org/10.1016/j.ijantimicag.2013.04.024 |
15.441 |
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Zheng H., Zeng Z., Chen S., Liu Y., Yao Q., Deng Y., Chen X., Lv L., Zhuo C., Chen Z., Liu J.-H. (2012). Prevalence and characterisation of CTX-M β-lactamases amongst Escherichia coli isolates from healthy food animals in China. Int J Antimicrob Agents., v.39, n.4, p.305-310. https://doi.org/10.1016/j.ijantimicag.2011.12.001 |
15.441 |
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Sun Y., Zeng Z., Chen S., Ma J., He L., Liu Y., Deng Y., Lei T., Zhao J., Liu J.-H. (2010). High prevalence of blaCTX-M extended-spectrum β-lactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China. Clinical Microbiology and Infection, v.16, n.9, p.1475-1481. https://doi.org/10.1111/j.1469-0691.2010.03127.x |
13.310 |
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Chen S., Barbieri J.T. (2009). Engineering botulinum neurotoxin to extend therapeutic intervention. Proceedings of the National Academy of Sciences of the United States of America, v.106, n.23, p.9180-9184. https://doi.org/10.1073/pnas.0903111106 |
12.779 |
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Shi J., Guo J., Bai G., Chan C., Liu X., Ye W., Hao J., Chen S, Yang M. (2015). A graphene oxide based fluorescence resonance energy transfer (FRET) biosensor for ultrasensitive detection of botulinum neurotoxin A (BoNT/A) enzymatic activity. Biosensors and Bioelectronics, v.65, p.238-244. https://doi.org/10.1016/j.bios.2014.10.050 |
12.545 |
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Zhang R., Liu L., Zhou H., Chan E.W., Li J., Fang Y., Li Y., Liao K., Chen S*. (2017). Nationwide Surveillance of Clinical Carbapenem-resistant Enterobacteriaceae (CRE) Strains in China. eBioMedicine, v.19, p.98-106. https://doi.org/10.1016/j.ebiom.2017.04.032 |
11.077 |