Prof. SIU Chi Kit Andy | Department of Chemistry

Prof. SIU Chi Kit Andy

蕭智傑教授

PhD (CUHK)

Associate Professor of Department of Chemistry

Contact Information

Office:	YEUNG - P5105
Phone:	34422272
Fax:	34420522
Email:	chiksiu@cityu.edu.hk
Web:	Personal Homepage

Research Interests

Computational chemistry
Density functional theory molecular dynamics studies on the mechanisms of chemical reactions at finite temperatures
Dissociation chemistry of biomolecular ions in the gas phase

Chi-Kit Andy Siu received his B.Sc. degree (1997) and M.Phil. (1999) and Ph.D. (2003) degrees from the Chinese University of Hong Kong under the supervision of Zhifeng Liu. He won an Alexander von Humboldt Fellowship in 2003 and worked as a postdoctoral fellow in the research group of Vladimir E. Bondybey at the Technical University of Munich (2003 - 2005). In 2005 - 2009, he worked as a postdoctoral fellow in the research groups of K. W. Michael Siu and Alan C. Hopkinson at York University. He joined the City University of Hong Kong in November 2009.

External service

Professional Activity

2022 - Now, President, Hong Kong Society of Mass Spectrometry
2020 - 2026, Subject Committee – Chemistry, Hong Kong Diploma of Secondary Education (HKDSE), Hong Kong Examinations and Assessment Authority (HKEAA)
Jan 2020, Co-Chair, The 8th Asia-Oceania Mass Spectrometry Conference (AOMSC2020).Macau.
Jul 2019, Chair, The 10th Conference of the Asian Consortium on Computational Materials Science (ACCMS-10).Hong Kong.
Dec 2018, Co-organizer, Hong Kong Society of Mass Spectrometry Workshop 2018: Troubleshooting and Maintenance of Your Powerful Mass Spectrometers.Hong Kong.
Jun 2018, Co-organizer, Hong Kong Society of Mass Spectrometry Symposium 2018.Hong Kong.
2018 - 2022, Vice President, Hong Kong Society of Mass Spectrometry.Hong Kong.
Jun 2016, Co-organizer, Hong Kong Society of Mass Spectrometry Symposium 2016.Hong Kong.
2016 - 2018, Honorary Secretary, Hong Kong Society of Mass Spectrometry.Hong Kong.
Mar 2015, Co-organizer, Hong Kong Society of Mass Spectrometry Workshop 2015: Theory & Practice in Shotgun Proteomics.Hong Kong.
Dec 2014, Co-Chair, Mass Spectrometry and Proteomics Workshop 2014: The Arts and Science of Mass Spectrometry - From Fundamentals to Applications.Hong Kong.
2014 - 2016, Council Member, Hong Kong Society of Mass Spectromery.
2013 - Now, Member, Royal Society of Chemistry.
2011 - Now, Member, American Chemical Society.
2006 - Now, Member, American Society for Mass Spectrometry.

Publications

Journal

M Ončák, CK Siu, C van der Linde, WK Tang, MK Beyer. Thermally Activated vs. Photochemical Hydrogen Evolution Reactions-A Tale of Three Metals. Chem. Eur. J. 2023, 29, e202203590 (DOI: 10.1002/chem.202203590).
C van der Linde, M Ončák, EM Cunningham, WK Tang, CK Siu, MK Beyer. Surface or Internal Hydration - Does It Really Matter? J. Am. Soc. Mass Spectrom. 2023, 34, 337-354 (DOI: 10.1021/jasms.2c00290).
EG Demissie, WK Tang, CK Siu. Structure−Property Relationship of Oxygen-Doped Two-Dimensional Gallium Selenide for Hydrogen Evolution Reaction Revealed from Density Functional Theory. ACS Appl. Energy Mater. 2022, 5, 6070-6079 (DOI: 10.1021/acsaem.2c00472)
L Cheng, TH Ma, BH Zhang, LB Huang, WH Guo, FJ Hu, H Zhu, ZY Wang, TT Zheng, DT Yang, CK Siu, Q Liu, Y Ren, C Xia, BZ Tang, RQ Ye. Steering the Topological Defects in Amorphous Laser-Induced Graphene for Direct Nitrate-to-Ammonia Electroreduction. ACS Catal. 2022, 12, 11639-11650 (DOI: 10.1021/acscatal.2c03219)
NFH Md Zin, SOY Shyen, BK Khor, NJY Chear, WK Tang, CK Siu, MR Razali, RA Haque, WS Yam. Cytotoxicity of asymmetric mononuclear silver(I)-N-heterocyclic carbine complexes against human cervical cancer: Synthesis, crystal structure, DFT calculations and effect of substituents. J. Organomet. Chem. 2022, 976, 122439 (DOI: 10.1016/j.jorganchem.2022.122439)
EG Demissie, WK Lam, H Thompson, WK Tang, CK Siu. Decomposition of Nitrous Oxide in Hydrated Cobalt(I) Clusters: A Theoretical Insight into Mechanistic Roles of Ligand-binding Modes. Phys. Chem. Chem. Phys. 2021, 23, 16816-16826 (DOI: 10.1039/D1CP01820E).
J Heller, WK Tang, EM Cunningham, EG Demissie, C van der Linde, WK Lam, M Ončák, CK Siu, MK Beyer. Getting Ready for the Hydrogen Evolution Reaction: The Infrared Spectrum of Hydrated Aluminum Hydride-Hydroxide HAlOH+(H2O)n-1, n = 9–14. Angew. Chem. Int. Ed. 2021, 60, 16858-16863 (DOI: 10.1002/anie.202105166).
ZF Xu, WK Tang, QY Zhou, S Chen, CK Siu, GY Zhu. On the hydrolytic stability of unsymmetric platinum(IV) anticancer prodrugs containing axial halogens. Inorg. Chem. Front. 2021, 8, 3794-3802 (DOI: 10.1039/D1QI00208B).
MA Rahim, GY Yeap, WK Tang, CK Siu. Experimental and DFT Studies on Well-Defined Odd-Even Effect in Organic Liquid Crystal Tetramers Incorporating Two Chiral Centers. Curr. Mat. Sci. 2021 (DOI: 10.2174/2666145414666210531123103).
Khoo, H. , Siu, CK. & So, CW. (2020). A Base-Stabilized Silylene-Promoted C(sp3)–H Borylation and H2 Activation. Inorg. Chem. 59. 9551 - 9559. doi:10.1021/acs.inorgchem.0c00426
Li, YN. , Li, MZ. , Spencer, DM. , Lau, JKC. , Martens, J. , Berden, G. , Oomens, J. , Fang, DC. , Hopkinson, AC. , Siu, KWM. , Siu, CK. & Chu, IK. (2020). Dissociative electron transfer of copper(ii) complexes of glycyl(glycyl/alanyl)tryptophan in vacuo: IRMPD action spectroscopy provides evidence of transition from zwitterionic to non-zwitterionic peptide structures. Phys. Chem. Chem. Phys. 22. 13084 - 13091. doi:10.1039/D0CP02296A
Tang, WK. , Mu, XY. , Li, MZ. , Martens, J. , Berden, G. , Oomens, J. , Chu, IK. & Siu, CK. (2020). Formation of n → π+ interaction facilitating dissociative electron transfer in isolated tyrosine-containing molecular peptide radical cations. Phys. Chem. Chem. Phys. 22. 21393 - 21402. doi:10.1039/d0cp00533a
Li, YN. , Li, MZ. , Spencer, DM. , Martens, J. , Oomens, J. , Siu, CK. & Chu, IK. (2020). Mechanistic examination of Cα–Cβ tyrosyl bond cleavage: Spectroscopic investigation of the generation of α‐glycyl radical cations from tyrosyl (glycyl/alanyl)tryptophan. J. Mass Spectrom. doi:10.1002/jms.4630
Leong, BX. , Lee, JW. , Li, Y. , Yang, MC. , Siu, CK. , Su, MD. & So, CW. (2019). A Versatile NHC-Parent Silyliumylidene Cation for Catalytic Chemo- and Regioselective Hydroboration. J. Am. Chem. Soc. 141. 17629 - 17636. doi:10.1021/jacs.9b06714
Mu, XY. , Tang, WK. , Dong, NP. , Siu, CK. & Chu, IK. (2019). Cα–Cβ bond cleavage occurs at the side chain of the N-terminal phenylalanine residue during CID of tyrosine-containing peptide radical cations. Int. J. Mass Spectrom. 435. 333 - 341. doi:10.1016/j.ijms.2018.10.025
Lai, CK. , Tang, WK. , Siu, CK. & Chu, IK. (2019). Evidence for the Prerequisite Formation of Phenoxyl Radical in Radical‐Mediated Peptide Tyrosine Nitration In Vacuo. Chem. Eur. J. 26. 331 - 335. doi:10.1002/chem.201904484
Herburger, A. , Ončák, M. , Siu, CK. , Demissie, EG. , Heller, J. , Tang, WK. & Beyer, MK. (2019). Infrared Spectroscopy of Size-Selected Hydrated Carbon Dioxide Radical Anions CO2•−(H2O)n (n=2–61) in the C―O Stretch Region. Chem. Eur. J. 25. 10165 - 10171. doi:10.1002/chem.201901650
Tang, WK. , Chau, MC. & Siu, CK. (2019). Role of Water in Molecular Oxygen Activation in Hydrated Chromium(I) Cluster Ions: A Theoretical Insight. Int. J. Mass Spectrom. 436. 118 - 126. doi:10.1016/j.ijms.2018.12.002
van der Linde, C. , Tang, WK. , Siu, CK. & Beyer, MK. (2018). Kinetics of the reaction of CO3-(H2O)n, n = 0, 1, 2, with nitric acid, a key reaction in tropospheric negative ion chemistry. Phys. Chem. Chem. Phys. 20. 10838 - 10845. doi:10.1039/c7cp07773d
Yu, XY. , Chau, MC. , Tang, WK. , Siu, CK. & Yao, ZP. (2018). Self-Assembled Binuclear Cu(II)–Histidine Complex for Absolute Configuration and Enantiomeric Excess Determination of Naproxen by Tandem Mass Spectrometry. Anal. Chem. 90. 4089 - 4097. doi:10.1021/acs.analchem.7b05407
Mu, XY. , Song, T. , Siu, CK. & Chu, IK. (2018). Tautomerization and Dissociation of Molecular Peptide Radical Cations. Chem. Rec. 18. 20 - 44. doi:10.1002/tcr.201700013
Tang, WK. , van der Linde, C. , Siu, CK. & Beyer, MK. (2017). Hydration Leads to Efficient Reactions of the Carbonate Radical Anion with Hydrogen Chloride in the Gas Phase. J. Phys. Chem. A. 121(1). 192 - 197. doi:10.1021/acs.jpca.6b09715
Akhgarnusch, A. , Tang, WK. , Zhang, H. , Siu, CK. & Beyer, MK. (2016). Charge Transfer Reactions between Gas-Phase Hydrated Electrons, Molecular Oxygen and Carbon Dioxide at Temperatures of 80 - 300 K. Phys. Chem. Chem. Phys. 18. 23528 - 23537. doi:10.1039/C6CP03324E
van der Linde, C. , Tang, WK. , Siu, CK. & Beyer, MK. (2016). Electrons Mediate the Gas-Phase Oxidation of Formic Acid with Ozone. Chem. Eur. J. (Communication). 22. 12684 - 12687. doi:10.1002/chem.201603080
Chu, IK. , Siu, CK. , Lau, JKC. , Tang, WK. , Mu, XY. , Lai, CK. , Guo, XH. , Wang, X. , Li, N. , Xia, Y. , Kong, XL. , Oh, HB. , Ryzhov, V. , Tureček, F. , Hopkinson, AC. & Siu, KWM. (2015). Proposed nomenclature for peptide ion fragmentation. Int. J. Mass Spectrom. 390. 24 - 27. doi:10.1016/j.ijms.2015.07.021
Herber, I. , Tang, WK. , Wong, HY. , Lam, TW. , Siu, CK. & Beyer, MK. (2015). Reactivity of Hydrated Monovalent First Row Transition Metal Ions [M(H2O)n]+, M = Cr, Mn, Fe, Co, Ni, Cu, and Zn, n < 50, Toward Acetonitrile. J. Phys. Chem. A. 119. 5566 - 5578. doi:10.1021/acs.jpca.5b02946
Lam, TW. , Zhang, H. & Siu, CK. (2015). Reductions of Oxygen, Carbon Dioxide, and Acetonitrile by the Magnesium(II)/Magnesium(I) Couple in Aqueous Media: Theoretical Insights from a Nano-Sized Water Droplet. J. Phys. Chem. A. 119. 2780 - 2792. doi:10.1021/jp511490n
Tang, WK. , Leong, CP. , Hao, Q. & Siu, CK. (2015). Theoretical examination of competitive β-radical-induced cleavages of N-Cα and Cα-C bonds of peptides. Can. J. Chem. 93. 1355 - 1362. doi:10.1139/cjc-2015-0208
Xu, MJ. , Tang, WK. , Mu, XY. , Ling, Y. , Siu, CK. & Chu, IK. (2015). α-Radical-Induced CO2 Loss from the Aspartic Acid Side Chain of the Collisionally Induced Tripeptide Aspartylglycylarginine Radical Cation. Int. J. Mass Spectrom. 390. 56 - 62. doi:10.1016/j.ijms.2015.06.002
Mu, XY. , Song, T. , Xu, MJ. , Lai, CK. , Siu, CK. , Laskin, J. & Chu, IK. (2014). Discovery and Mechanistic Studies of Facile N-Terminal Cα–C Bond Cleavages in the Dissociation of Tyrosine-Containing Peptide Radical Cations. J. Phys. Chem. B. 118. 4273 - 4281. doi:10.1021/jp410525f
Akhgarnusch, A. , Höckendorf, RF. , Hao, Q. , Jäger, P. , Siu, CK. & Beyer, MK. (2013). Carboxylation of Methyl Acrylate by Carbon Dioxide Radical Anions in Gas-Phase Water Clusters. Angew. Chem. Int. Ed. 52. 9327 - 9330. doi:10.1002/anie.201302827
Höckendorf, RF. , Fischmann, K. , Hao, Q. , van der Linde, C. , Balaj, OP. , Siu, CK. & Beyer, MK. (2013). C-C Bond Formation between CO2•− and Allyl Alcohol: A Mechanistic Study. Int. J. Mass Spectrom. (Invited Article). 354-355. 175 - 180. doi:10.1016/j.ijms.2013.05.027
Song, T. , Ma, CY. , Chu, IK. , Siu, CK. & Laskin, J. (2013). Mechanistic Examination of Cβ–Cγ Bond Cleavages of Tryptophan Residues during Dissociations of Molecular Peptide Radical Cations. J. Phys. Chem. A. 117. 1059 - 1068. doi:10.1021/jp303562e
Quan, Q. , Hao, Q. , Song, T. , Siu, CK. & Chu, IK. (2013). Mechanistic Investigation of Phosphate Ester Bond Cleavages of Glycylphosphoserinyltryptophan Radical Cations under Low-Energy Collision-Induced Dissociation. J. Am. Soc. Mass Spectrom. 24. 554 - 562. doi:10.1007/s13361-013-0597-x
Akhgarnusch, A. , van der Linde, C. , Akhgarnusch, A. , Hao, Q. , Beyer, MK. & Siu, CK. (2013). Reduction of CH3CN in Hydrated Magnesium Cations Mg+(H2O)n, n ~ 20 – 60, in the Gas Phase. ChemPlusChem (Invited Article). 78. 1040 - 1048. doi:10.1002/cplu.201300170
Hao, Q. , Song, T. , Ng, DCM. , Quan, Q. , Siu, CK. & Chu, IK. (2012). Arginine-Facilitated Isomerization: Radical-Induced Dissociation of Aliphatic Radical Cationic Glycylarginyl(Iso)leucine Tripeptides. J. Phys. Chem. B. 116. 7627 - 7634.
Kong, RPW. , Quan, Q. , Hao, Qiang. , Lai, CK. , Siu, CK. & Chu, IK. (2012). Formation and Dissociation of Phosphorylated Peptide Radical Cations. J. Am. Soc. Mass Spectrom. 23. 2094 - 2101. doi:10.1007/s13361-012-0479-7
Song, T. , Hao, Q. , Law, CH. , Siu, CK. & Chu, IK. (2012). Novel Cß-CΥ Bond Cleavages of Tryptophan-Containing Peptide Radical Cations. J. Am. Soc. Mass Spectrom. 23. 264 - 273.
Höckendorf, RF. , Hao, Q. , Sun, Z. , Fox-Beyer, BS. , Cao, YL. , Balaj, OP. , Bondybey, VE. , Siu, CK. & Beyer, MK. (2012). Reactions of CH3SH and CH3SSCH3 with Gas-Phase Hydrated Radical Anions (H2O)n•–, CO2•–(H2O)n and O2•–(H2O)n. J. Phys. Chem. A. 116. 3824 - 3835.
Verkerk, UH. , Zhao, J. , Lau, JKC. , Lam, TW. , Hao, Q. , Steill, JD. , Siu, CK. , Oomens, J. , Hopkinson, AC. & Siu, KWM. (2012). Structures of a2 ion of Ala-Ala-Ala and Phe-Phe-Phe. Int. J. Mass Spectrom. 330-332. 254 - 261. doi:10.1016/j.ijms.2012.08.034
Song, T. , Ng, DCM. , Quan, Q. , Siu, CK. & Chu, IK. (2011). Arginine-Facilitated α- and π-Radical Migrations in Glycylarginyltryptophan Radical Cations. Chem. Asian J. 6. 888 - 898.
Xu, MJ. , Song, T. , Quan, Q. , Hao, Q. , Fang, DC. , Siu, CK. & Chu, IK. (2011). Effect of the N-terminal Basic Residue on Facile Cα–C Bond Cleavages of Aromatic-Containing Peptide Radical Cations. Phys. Chem. Chem. Phys. 13. 5888 - 5896.
van der Linde, C. , Akhgamusch, A. , Siu, CK. & Beyer, MK. (2011). Hydrated Magnesium Cations Mg+(H2O)n, n ≈ 20 – 60, Exhibit Chemistry of the Hydrated Electron in Reactions with O2 and CO2. J. Phys. Chem. A. 115. 10174 - 10180.
Ke, YY. , El Aribi, H. , Siu, CK. , Siu, KWM. & Hopkinson, AC. (2010). A Comparison of the Fragmentation Pathways of [CuII(Ma)(Mb)]•2+ Complexes where Ma and Mb are Peptides containing either a Tryptophan or a Tyrosine Residue. Rapid Commun. Mass Spectrom. 24. 3485 - 3492.
omanov, V. , Verkerk, UH. , Siu, CK. , Hopkinson, AC. & Siu, KWM. (2010). Bond Dissociation Energies of Solvated Silver(I)-Amide Complexes: Competitive Threshold Collision-Induced Dissociations and Calculations. J. Phys. Chem. A. 114. 6964 - 6971.
Ng, DCM. , Song, T. , Siu, SO. , Siu, CK. , Laskin, J. & Chu, IK. (2010). Formation, isomerization, and dissociation of α-carbon-centered and π-centered glycylglycyltryptophan radical cations. J. Phys. Chem. B. 114. 2270 - 2280.
Siu, CK. , Guo, YZ. , Saminathan, IS. , Hopkinson, AC. & Siu, KWM. (2010). Optimization of Parameters Used in Algorithms of Ion-Mobility Calculation for Conformational Analyses. J. Phys. Chem. 114. 1204 - 1212.
Hockendorf, RF. , Siu, CK. , van der Linde, C. , Balaj, OP. & Beyer, MK. (2010). Selective Formic Acid Synthesis from Nanoscale Electrochemistry. Angew. Chem. Int. Ed. 49. 8257 - 8259.
Verkerk, UH. , Siu, CK. , Steill, JD. , El Aribi, H. , Zhao, JF. , Rodriquez, CF. , Oomens, J. , Hopkinson, AC. & Siu, KWM. (2010). The a2 Ion Derived from Triglycine is an N1-Protonated 4-Imidazolidinone. J. Phys. Chem. Lett. 1. 868 - 872.
Zhao, JF. , Siu, CK. , Shi, TJ. , Hopkinson, AC. & Siu, KWM. (2009). Abundant Dipositively Charged Protonated a2 and a3 Ions From Diproline and Triproline. J. Phys. Chem. 14. 4963 - 4969.
Dunbar, RC. , Hopkinson, AC. , Oomens, J. , Siu, CK. , Siu, KWM. , Steill, JD. , Verkerk, UH. & Zhao, JF. (2009). Conformation Switching in Gas-Phase Complexes of Histidine with Alkaline Earth Ions. J. Phys. Chem. 30. 10403 - 10408.
Siu, CK. , Zhao, JF. , Laskin, J. , Chu, IK. , Hopkinson, AC. & Siu, KWM. (2009). Kinetics for Tautomerizations and Dissociations of Triglycine Radical Cations. J. Am. Soc. Mass Spectrom. 20. 996 - 1005.
Romanov, V. , Verkerk, UH. , Siu, CK. , Hopkinson, AC. & Siu, KWM. (2009). Threshold Collision-Induced Dissociation Measurements using a Ring Ion Guide as the Collision Cell in a Triple-Quadrupole Mass Spectrometer. Anal. Chem. 81. 6805 - 6812.
Romanov, V. , Siu, CK. , Verkerk, UH. , El Aribi, H. , Hopkinson, AC. & Siu, KWM. (2008). Binding Energies of the Silver Ion to Alcohols and Amides: A Theoretical and Experimental Study. J. Phys. Chem. A. 112. 10912 - 10920.
Shi, TJ. , Siu, CK. , Siu, KWM. & Hopkinson, AC. (2008). Dipositively Charged Protonated a3 and a2 Ions: Generation by Fragmentation of [La(GGG)(CH3CN)2]3+. Angew. Chem. Int. Ed. 47. 8288 - 8291.
Siu, CK. , Ke, YY. , Oriova, G. , Hopkinson, AC. & Siu, KWM. (2008). Dissociation of the N–Cα Bond and Competitive Formation of the [zn-H]●+ and [cn+2H]+ Product Ions in Radical Peptide Ions Containing Tyrosine and Tryptophan; The Influence of Proton Affinities on Product Formation. J. Am. Soc. Mass Spectrom. 19. 1799 - 1807.
Siu, CK. , Ke, YY. , Guo, YZ. , Hopkinson, AC. & Siu, KWM. (2008). Dissociations of Copper(II)-Containing Complexes of Aromatic Amino Acids: Radical Cations of Tryptophan, Tyrosine, and Phenylalanine. Phys. Chem. Chem. Phys. 10. 5908 - 5918.
Steill, J. , Zhao, JF. , Siu, CK. , Ke, YY. , Verkerk, UH. , Oomens, J. , Dunbar, RC. , Hopkinson, AC. & Siu, KWM. (2008). Structure of the Observable Histidine Radical Cation in the Gas Phase: a Captodative α-Radical Ion. Angew. Chem. Int. Ed. 47. 9666 - 9668.
Siu, CK. , Reitmeier, SJ. , Balteanu, I. , Bondybey, VE. & Beyer, MK. (2007). Catalyst Poisoning in the Conversion of CO and N2O to CO2 and N2 on Pt4- in the Gas Phase. Eur. Phys. J. D. 43. 189 - 192.
Siu, CK. , Balaj, OP. , Balteanu, I. , Fox-Beyer, BS. , Beyer, MK. & Bondybey, VE. (2007). Reactions of Large Water Cluster Anions with Hydrogen Chloride: Formation of Atomic Hydrogen and Phase Separation in the Gas Phase. J. Am. Chem. Soc. 129. 3238 - 3246.
Siu, CK. , Fox-Beyer, BS. , Beyer, MK. & Bondybey, VE. (2006). Ab initio Molecular Dynamics Studies of Ionic Dissolution and Precipitation of Sodium Chloride and Silver Chloride in Water Clusters, NaCl(H2O)n and AgCl(H2O)n, with n = 6, 10, and 14. Chem. Eur. J. 12. 6382 - 6392.
Rodriquez, CF. , Oriova, G. , Guo, YZ. , Li, XM. , Siu, CK. , Hopkinson, AC. & Siu, KWM. (2006). Gaseous Bradykinin and Its Singly, Doubly, and Triply Protonated Forms: A First-Principles Study. J. Phys. Chem. B. 110. 7528 - 7537.
Siu, CK. , Guo, YZ. , Hopkinson, AC. & Siu, KWM. (2006). How Large Is the [FeIII(Protoporphyrin IX)]+ Ion (Hemin+) in the Gas Phase?. J. Phys. Chem. B. 110. 24207 - 24211.
Sun, Z. , Siu, CK. , Balaj, OP. , Gruber, M. , Bondybey, VE. & Beyer, MK. (2006). Proton Transfer in Ionic Water Clusters. Angew. Chem. Int. Ed. 45. 4027 - 4030.
Siu, CK. & Liu, ZF. (2005). Reaction Mechanisms for the Size-Dependent Hydrogen-Loss in Mg+(H2O)n: Solvation Controlled Electron Transfer. Phys. Chem. Chem. Phys. 7. 1005 - 1013.
Chan, KW. , Siu, CK. , Wong, SY. & Liu, ZF. (2005). The Elimination of a Hydrogen Atom in Na(H2O)n. J. Chem. Phys. 123. 124313 .
Balaj, OP. , Siu, CK. , Balteanu, I. , Fox-Beyer, BS. , Beyer, MK. & Bondybey, VE. (2004). Base-Catalyzed Hydrogen/Deuterium Exchange between Water and Acetonitrile in Anionic Water Clusters. J. Phys. Chem. A. 108. 7506 - 7512.
Balaj, OP. , Siu, CK. , Balteanu, I. , Beyer, MK. & Bondybey, VE. (2004). Free Electrons, the Simplest Radicals of Them All: Chemistry of Aqueous Electrons as Studied by Mass Spectrometry. Int. J. Mass Spectrom. (Review). 238. 65 - 74.
Balaj, OP. , Siu, CK. , Balteanu, I. , Beyer, MK. & Bondybey, VE. (2004). Reactions of Hydrated Electrons (H2O)n- with Carbon Dioxide and Molecular Oxygen: Hydration of the CO2- and O2- Ions. Chem. Eur. J. 10. 4822 - 4830.
Siu, CK. , Liu, ZF. & Tse, JS. (2002). Ab Initio Studies on Al+(H2O)n, HAlOH+(H2O)n-1, and the Size-Dependent H2 Elimination Reaction. J. Am. Chem. Soc. 124. 10846 - 10860.
Siu, CK. & Liu, ZF. (2002). Ab Initio Studies on the Mechanism of the Size-Dependent Hydrogen-Loss Reaction in Mg+(H2O)n. Chem. Eur. J. 8. 3177 - 3186.
Liu, ZF. , Siu, CK. & Tse, JS. (1999). Ab initio Molecular Dynamics Study on the Hydrolysis of Molecular Chlorine. Chem. Phys. Lett. 311. 93 - 101.
Liu, ZF. , Siu, CK. & Tse, JS. (1999). Ab initio Molecular Dynamics Study on the Thermal Dissociation of Acetic Acid. Chem. Phys. Lett. 314. 317 - 325.
Liu, ZF. , Siu, CK. & Tse, JS. (1999). Catalysis of the Reaction HCl + HOCl --> H2O + Cl2 on an Ice Surface. Chem. Phys. Lett. 309. 335 - 343.

Research Positions Available

Ph.D. / M.Phil. positions in theoretical and computational chemistry are currently available. For interested candidates, please contact Dr. C. K. Andy Siu (together with your CV) at chiksiu@cityu.edu.hk.

Awards and Achievements

2003 “Postdoctoral Fellowship” Alexander von Humboldt-Foundation.

Services in CityU

Administrative Assignment

2022 - Now, Programme Leader, Global Research Enrichment and Technopreneurship (GREAT), College of Science
2018 - Now, Departmental Alumni-Student Committee , Chairman.
2017 - Now, BVM Programme Committee , CHEM Representative.
2017 - Now, Departmental Scholarships/Awards Selection Panel, Coordinator.
2017 - Now, Directed Studies Committee for Undergraduate, Member.
2017 - Now, Postgraduate Student Seminar, Staff-in-charge.
2016 - Now, Departmental BSc Joint Staff-Student Consultative Committee, Member.
2016 - Now, Departmental BSc Major Programme Committee, Year 4 Tutor.
2016 - 2018, Departmental Committee on Research Student Affairs, Member.
2015 - 2020, ACE Programme Committee , CHEM Representative.
2014 - Now, Departmental e-Learning , Coordinator.
2014 - 2018, Departmental Research Education Committee, Member.
2014 - 2017, Departmental Students’ Conference Organizing Committee, Member.
2012 - 2016, Internationalization Committee of CSE, Member.
2010 - 2017, Departmental Social Activities, Convener.
2010 - Now, Departmental Student Exchange, Coordinator.

Teaching Service

2017 - Now, MSc, BCH6118, Advanced Chemical Instrumentation (Mass Spectrometry and Related Topics).
2015 - Now, Gateway Education, GE1346 The Chemists’ Kitchen (The Science of Food and Cooking).
2013 - 2015, Gateway Education, GE1302 The Science of Art (“The Sound of Music”).
2012 - Now, UG, BCH1100 Chemistry.
2011 - 2012, UG, BCH2803 Environment: Stresses and Solutions.
2010 - 2012, UG, BCH1049 Chemistry I.
2010 - 2012, UG, BCH2005 Principles of Environmental Chemistry (Atmospheric Chemistry).
2010 - Now, UG, BCH3015 Organic Chemistry (Spectroscopy).
2010 - Now, PhD, BCH8008 Advanced Chemical Instrumentation for Research (Mass Spectrometry and Related Topics).

Previous Experience

2009 - 2015, Assistant Professor, City University of Hong Kong.
2005 - 2009, Postdoctoral Fellow, Department of Chemistry and Centre for Research in Mass Spectrometry, York University, Canada.
2003 - 2005, Postdoctoral Fellow, Institut für Physikalische und Theoretische Chemie, Technische Universität München, Germany.
2002 - 2003, Research Assistant, Department of Chemistry, the Chinese University of Hong Kong.
1997 - 2002, Graduate Assistant, Department of Chemistry, Chinese University of Hong Kong.

Research Grants

Theoretical Improvement of Photocatalytic Activity of Two-dimensional GaSe, GaS and Their Heterostructures for Water Splitting via Doping and Strain, GRF, RGC, Amount: HKD $598,015, Oct 2021 - Sep 2024, Siu, CK (PI).
Theoretical Examination of Reaction Dynamics of Hydrated Carbon Dioxide Radical Anion toward Unsaturated Organic Compounds in the Gas Phase and Implication on Solvation Structures of Aqueous-Organic N, GRF, RGC, Amount: HKD $599,861, Jan 2021 - Dec 2024, Siu, CK (PI).
Theoretical examinations for the dissociative electron transfers of the prototypical disulfide linkage with a hydrated electron and carbon dioxide radical anion in water clusters and aqueous solution, GRF, RGC, Amount: HKD $502,444, Dec 2019 - Nov 2022, Siu, CK (PI).
Theoretical Prediction on the Formation of Highly Oxidized Organic Compounds with Relevance to Early Stages of Atmospheric Nucleation, City University of Hong Kong, Amount: HKD $100,000, Sep 2018 - Aug 2020, Siu, CK (PI).
Sequence, Proximity & Electronic Factors Affecting Electron Transfers from the N-terminal NH2 Group to the π-radical Tautomer of Tyrosine Residue in Molecular Peptide Radical Cations in the Gas Phase, GRF, RGC, Amount: HKD $522,898, Aug 2017 - Jul 2020, Siu, CK (PI).
Exploration of Solvation Structures and Water-reduction Mechanisms of Hydrated Clusters of Monovalent Vanadium Ion, City University of Hong Kong, Amount: HKD $100,000, Sep 2015 - Aug 2017, Siu, CK (PI).
Characterization of the Solvation Structures and Dynamics for the Reactions of M+(H2O)n (M = Mg and V) Toward CO2, O2, or CH3CN in the Gas Phase By Means of Density Functional Theory, City University of Hong Kong, Amount: HKD $100,000, Sep 2014 - Aug 2015, Siu, CK (PI).
Theoretical Examinations of Competitive Bond Cleavages Induced by the beta-radical in Peptide Radical Cations in the Gas Phase, City University of Hong Kong, Amount: HKD $100,000, Oct 2013 - Sep 2014, Siu, CK (PI).
Theoretical Examination of C-C Bond Formation between Carbon Dioxide Radical Anion and Methyl Acrylate in Nano-sized Water Clusters, City University of Hong Kong, Amount: HKD $70,000, Oct 2012 - Sep 2013, Siu, CK (PI).
Mechanistic Examinations for the Roles of the Charge and Radical on Isomerizations and Dissociations of Phosphorylated Tripeptide Radical Cations, City University of Hong Kong, Amount: HKD $180,000, Apr 2012 - Apr 2014, Siu, CK (PI).
Theoretical Examinations of the Dynamics of Hypervalent Peptide Radicals, General Research Fund, Research Grants Council, Amount: HKD $1,083,753, Nov 2011 - Oct 2014, Siu, CK (PI).
Functionalization of Carbon Dioxide in Nano-water Droplets, Germany/Hong Kong Joint Research Scheme, Research Grants Council, Amount: HKD $59,200, Jan 2011 - Dec 2012, Siu, CK (PI).
Dynamics of Proton Transfer and Cyclization of Protonated Peptides and Their Fragments in the Gas Phase, General Research Fund, Research Grants Council, Amount: HKD $775,700, Jul 2010 - Jun 2013, Siu, CK (PI).
Dissociation Dynamics of Molecular Triglycine Radical Cations, City University of Hong Kong, Amount: HKD $180,000, May 2010 - Apr 2012, Siu, CK (PI).
Examination of Disulfide-Linkage Cleavages in Electron-Capture Dissociations by Means of Density Functional Theory Molecular Dynamics Methods, City University of Hong Kong, Amount: HKD $250,000, Jan 2010 - Dec 2011, Siu, CK (PI).

Student Organization

2010 - now, Principal Horn, City University Philharmonic Orchestra