The project aims to develop the first wearable closed-loop drug delivery device (DDD) that uses tonoarteriography as real-time feedback for hypertension monitoring and drug delivery. It delivers drugs automatically based on continuous arterial blood pressure powered by an intelligent drug decision-making algorithm to determine optimal dosage. The DDD achieved by iontophoresisand chemical penetration enhancement increases delivery efficiency and accuracy. A wireless module connected to a mobile device allows remote feedback control by clinicians. Our device will bring precise and remote medicine to reality, improving clinical outcomes for millions of hypertensive patients and reduce pressure on the overburdened public healthcare system.