We are innovating nanopore technology for rapid, high throughput, multiplex detection of biomarkers for disease diagnosis and virus screening. Biomarkers in an electrically conductive solution produce an electrical signal as they pass through a nanometer hole (nanopore). This electrical signal is unique and each electrical “signature” can be analysed to identify the biomarker and quantify its concentration. We employed this nanopore property in our technology for RNA detection. We demonstrated this principal by measuring ultra-low quantities of COVID-19 mRNA without using PCR amplification.