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Dr. CHEN Ting-Hsuan (陳定璿博士)

BS(NTHU), MS(NTHU), PhD(UCLA)

Associate Professor

Contact Information

Office: P6415 AC1
Phone: 34424114
Fax: 34420172
Email: thchen@cityu.edu.hk
Web: Laboratory for Biomeasurement

Research Interests

  • Cell Mechanics
  • Tissue Morphogenesis
  • Bio-Sensor and Actuator
  • Micro/Nanotechnology
Ting-Hsuan Chen received his B.S. degree (2003) and M.S. degree (2005) in National Tsing Hua University, Taiwan, and obtained his Ph.D. degree in Mechanical Engineering at University of California, Los Angeles (2012). He is currently an Associate Professor in Biomedical Engineering at City University of Hong Kong. Dr. Chen has been spearheading projects leveraging the micro/nanotechnology for biomedical applications. He has made a fundamental discovery of cell’s intrinsic left-right bias and successfully exploited this finding to engineer patterns of microtissue. His recent research focusing on nanotechnologies for measurement of cell rotational mechanics and developing DNA nanosensors that detect biomarkers in live cells or visual assays for point-of-care applications. Many of his achievement was featured as cover stories in prestigious journals such as Circulation Research, Journal of Physiology, Biotechnnology and Bioengineering, and ACS Sensors, or published in top-tier journals such as ACS Nano, Biomaterials, ACS Applied Materials & Interfaces, and Analytical Chemistry. He was also a recipient of Best Conference Poster Award at IEEE NEMS conference in 2014, Best Conference Paper Award at conference of Optofluidics in 2016. Dr. Chen’ also served as a guest editor for IEEE Transaction of Nanotechnology and Micromachines, and is currently editorial board member of Heliyon, Elsevier.


Awards and Achievements

  • Jul 2016 “Best Paper Award” The 6th International Multidisciplinary Conference on Optofluidics.
  • Nov 2015 “Best Student Paper Award (final list)” The 9th IEEE International Conference on Nano/Molecular Medicine and Engineering.
  • Apr 2015 “Best Conference Poster Award” The 10th IEEE international Conference on Nano/Micro Engineered and Molecular Systems.
  • Sep 2010 “University Fellowship” University of California, Los Angeles.
  • Sep 2007 “Departmental Fellowship” Mechanical and Aerospace Engineering Department, University of California Los Angeles.
  • May 2021 “CENG Outstanding Teaching Award 2020-21” College of Engineering, City University of Hong Kong.
  • Dec 2021 “Innovative CityU-Learning Awards – Semester A, 2021/22” Talent and Education Development Office, City University of Hong Kong .


Previous Experience

  • Apr 2012 - Aug 2012, Postdoctoral Scholar, University of California, Los Angeles.
  • Jul 2007 - Aug 2008, Associate Engineer, Industrial Technology Research Institute.


Research Grants

  • 基于微流控磁粒子的前列腺癌视觉量化检测微芯片的研究, JCYJ20210324134006017, Science, Technology and Innovation Commission of Shenzhen, Amount: CNY $400,000, 28 Oct 2021 - 31 Oct 2024, Ting-Hsuan Chen (PI).
  • Engineering Functional Skeletal Muscle Sheets for Bionic Applications, General Research Fund, Research Grant Council, Amount: HKD $1,043,946, 1 Jan 2021 - 31 Dec 2023, Ting-Hsuan Chen (PI).
  • Exploration of Cell Chirality Using Material Surface Patterning, NSFC/RGC Joint Research Scheme 2019-2020, General Research Fund, Research Grant Council, Amount: HKD $1,176,537, 1 Jan 2020 - 31 Dec 2023, Ting-Hsuan Chen (PI), Jiandong Ding (Fudan University, Co-PI).
  • Microengineered Ratchet Patterns in Nanowire Magnetoscope for Directing Rotational Bias and Programmed Cell Live/Death, General Research Fund, Research Grant Council, Amount: HKD $443,950, 1 Jan 2018 - 31 Dec 2020, Ting-Hsuan Chen (PI), Miu Ling Lam (Co-I).
  • Development of Automated Microscopy Revealing Rotational Mechanics of Cells for Characterizing Left-Right Symmetry Breaking in Lineage Commitment, Basic Research Free Exploration Program, The Science Technology and Innovation Committee of Shenzhen , Amount: CNY $300,000, 26 May 2017 - 31 May 2019, Ting-Hsuan Chen (PI).
  • Directing Left-Right Asymmetry in Tissue Formation via Micropatterned Substrate with Varying Stiffness, General Research Fund, Research Grant Council, Amount: HKD $482,605, 1 Jan 2017 - 31 Dec 2019, Ting-Hsuan Chen (PI), Miu Ling Lam (Co-I).
  • Detection of MicroRNAs Based on Magnetophoresis of Microparticles, Basic Research Free Exploration Program, The Science Technology and Innovation Committee of Shenzhen , Amount: CNY $300,000, 15 Oct 2016 - 31 Oct 2017, Ting-Hsuan Chen (PI).
  • Automated Torque Microscopy to Investigate Cellular Left-Right Asymmetry with respect to Stem Cell Differentiation, Early Career Scheme, Research Grant Council, Amount: HKD $726,075, Jan 2016 - Dec 2018, Ting-Hsuan Chen (PI).
  • Biosensor Design House, Idea Incubator Scheme, City University of Hong Kong, Amount: HKD $492,600, Jul 2015 - Jun 2016, Ting-Hsuan Chen (PI), King W. C. Lai (Co-I), Miu Ling Lam (Co-I), Eddie C. H. Ma (Co-I).
  • Nucleic Acid Detection Using Coffee Ring Effect for Point-of-Care Applications, Strategic Research Grant, City University of Hong Kong, Amount: HKD $100,000, Sep 2014 - Aug 2015, Ting-Hsuan Chen (PI).
  • Point-of-care Detection of Botulinum Neurotoxin using Coffee Ring Effect, Applied Research Grant, City University of Hong Kong, Amount: HKD $200,000, Apr 2014 - Sep 2015, Ting-Hsuan Chen (PI), Miu Ling Lam (Co-I).
  • Investigation of Mechanical Role in Cancer Physiology and Therapeutic Strategy Using Microscale Torque and Micropatterning, National Natural Science Foundation of China, Amount: CNY $250,000, 1 Jan 2014 - 31 Dec 2016, Ting-Hsuan Chen (PI).


Patents

  • Ting-Hsuan Chen, Zichen Zhao, Device And Method for Visual Quantification of An Amount of Target Species in A Sample Solution, US Patent No. 10981165, 20 Apr 2021.
  • Kit and a Method for Determining the Presence or Amount of a Target Nucleic Acid Sequence in a Sampl, US Patent No. 10519487, 31 Dec 2019.
  • Detection of Analyte Using Coffee-Ring Effect, US Patent No. 9389162 B2, 12 Jul 2016.
  • A surface plasmon resonance detecting apparatus and method thereof, Taiwan Patent No. 200916758, Apr 2009.
  • Pressure Relief Valve and The Fabrication Method Thereof and Sphygmomanometer, Taiwan Patent No. 200916055, Apr 2009.


Publications Show All Publications Show Prominent Publications


Journal

  • Cui, Chenyu. , Lau, Cia-Hin. , Tin, Chung. & Chen, Ting-Hsuan*. (2023 15 Jan 2023). Multimodal Detection of Flap Endonuclease 1 Activity through CRISPR/Cas12a Trans-cleavage of Single-strand DNA Oligonucleotides. Biosensors and Bioelectronics. 220. 114859 .
  • Chu, Lok Ting. , Kwong, Hoi Kwan. , Hartanto, Hogi. & Chen, Ting-Hsuan*. (2022 15 Dec 2022). Detection of intracellular sodium ions based on phenotype-specific activation of NaA43 DNAzyme. Biosensors and Bioelectronics. 218. 114753 .
  • Wang, Gaobo. , Li, Jiaheng. , Wu, Siying. , Jiang, Tianyi. & Chen, Ting-Hsuan*. (2022 10 Nov 2022). A Fully Integrated, Ready-to-Use Distance-Based Chemosensor for Visual Quantification of Multiple Heavy Metal Ions. Analytical Chemistry. 94/46. 15925 - 15929.
  • Wu, Minghui. , Wu, Siying. , Wang, Gaobo. , Liu, Wengang. , Chu, Lok Ting. , Jiang, Tianyi. , Kwong, Hoi Kwan. , Chow, Hiu Lam. , Li, Iris Wai Sum. & Chen, Ting-Hsuan*. (3 Jun 2022). Microfluidic particle dam for direct visualization of SARS-CoV-2 antibody levels in COVID-19 vaccinees. Science Advances. 8/22. eabn6064 .
  • Cui, Chenyu. & Chen, Ting-Hsuan*. (30 Dec 2021). Visual Quantitation of Copper Ions Based on a Microfluidic Particle Dam Reflecting the Cu(II)-Catalyzed Oxidative Damage of DNA. Biosensors (Basel). 11/12. 487 .
  • Wu, Siying. , Wu, Minghui. , Wang, Gaobo. & Chen, Ting-Hsuan*. (1 Dec 2021). Visual quantitation of silver contamination in fresh water via accumulative length of microparticles in capillary-driven microfluidic devices. Talanta. 235. 122707 .
  • Wang, Gaobo. , Wu, Minghui. , Chu, Lok Ting. & Chen, Ting-Hsuan*. (22 May 2021). Portable microfluidic device with thermometer-like display for real-time visual quantitation of Cadmium(II) contamination in drinking water. Analytica Chimica Acta. 1160. 338444 .
  • Jiang, Gaobo Wang, Ting-Hsuan Chen, Tianyi. , Wang, Gaobo. & Chen, Ting-Hsuan*. (27 Apr 2021). Microfluidic particle accumulation for visual quantitation of copper ions. Microchimica Acta. 188. 176 .
  • Hartanto, Hogi. , Wu, Minghui. , Lam, Miu Ling. & Chen, Ting-Hsuan*. (14 Dec 2020). Microfluidic immunoassay for detection of serological antibodies: A potential tool for rapid evaluation of immunity against SARS-CoV-2. Biomicrofluidics. 14. 061507 .
  • Wu, Minghui. , Wang, Gaobo. , Chu, Lok Ting. , Huang, Hanjin. & Chen, Ting-Hsuan*. (9 Aug 2020). Cascade-Amplified Microfluidic Particle Accumulation Enabling Quantification of Lead Ions through Visual Inspection. Sensors and Actuators B: Chemical. 324. 128727 .
  • Bao, Yuanye. , Wu, Siying. , Chu, Lok Ting. , Kwong, Hoi Kwan. , Hartanto, Hogi. , Huang, Yaozhun. , Lam, Miu Ling. , Lam, Raymond H. W. & Chen, Ting-Hsuan*. (4 Aug 2020). Early Committed Clockwise Cell Chirality Up-Regulates Adipogenic Differentiation of Mesenchymal Stem Cells. Advanced Biosystems. 4/10. 2000161 doi:doi.org/10.1002/adbi.202000161
  • Chu, Lok Ting. , Leung, Hoi Man. , Lo, Pik Kwan. & Chen, Ting-Hsuan*. (9 Dec 2019). Visual detection of lead ions based on nanoparticle-amplified magnetophoresis and Mie scattering. Sensors and Actuators B: Chemical. 306. 127564 doi:10.1016/j.snb.2019.127564
  • Wang, Gaobo. , Chu, Lok Ting. , Hartanto, Hogi. , Utomo, William. Budi. , Pravasta, Reynard. Aaron. & Chen, Ting-Hsuan*. (6 Dec 2019). Microfluidic Particle Dam for Visual and Quantitative Detection of Lead Ions. ACS Sensors. 5. 19 - 23. doi:10.1021/acssensors.9b01945
  • Kwong, Hoi Kwan. , Huang, Yaozhun. , Lam, Miu Ling. & Chen, Ting-Hsuan*. (4 Jun 2019). Remnant Effects of Culture Density on Cell Chirality After Reseeding. ACS Biomaterials Science & Engineering. 5. 3944 - 3953. doi:10.1021/acsbiomaterials.8b01364
  • Huang, Yaozhun. , Bao, Yuanye. , Kwong, Hoi Kwan. , Chen, Ting-Hsuan*. & Lam, Miu Ling*. (26 Jun 2018). Outline‐etching image segmentation reveals enhanced cell chirality through intercellular alignment. Biotechnology and Bioengineering. 115. 2595 - 2603. doi:10.1002/bit.26783
  • Chen, Ting-Hsuan. , Chen, Jie-Sheng. , Ko, Yi-Ching. , Chen, Jyun-Wei. , Chu, Hsueh-Yao. , Lu, Chih-Shuan. , Chu, Chiao-Wen. , Hsu, Hsiang-Hao. & Tseng, Fan-Gang*. (3 Mar 2018). A Microfluidic Platform for Investigating Transmembrane Pressure-Induced Glomerular Leakage. Micromachines. 9/5. 228 doi:10.3390/mi9050228
  • Hu, Shuhuan. , Chen, Ting-Hsuan. , Zhao, Yanhua. , Wang, Zuankai. & Lam, Raymond. H. W.*. (5 Jan 2018). Protein–Substrate Adhesion in Microcontact Printing Regulates Cell Behavior. Langmuir. 34/4. 1750 - 1759. doi:10.1021/acs.langmuir.7b02935
  • Zhao, Zichen. , Bao, Yuanye. , Chu, Lok Ting. , Ho, John. K. L. , Chieng, Ching-Chang. & Chen, Ting-Hsuan*. (23 Aug 2017). Microfluidic Bead Trap as a Visual Bar for Quantitative Detection of Oligonucleotides. Lab on a Chip. 17. 3240 - 3245. doi:10.1039/C7LC00836H
  • Zhu, Ninghao. , Kwong, Hoi Kwan. , Bao, Yuanye. & Chen, Ting-Hsuan*. (8 Jun 2017). Chiral Orientation of Skeletal Muscle Cells Requires Rigid Substrate. Micromachines. 8/6. 181 .
  • Au Ieong, Ka I. , Yang, Chengpeng. , Wong, Chin To. , Shui, Angelie. C. , Wu, Tom. T. Y. , Chen, Ting-Hsuan. & Lam, Raymond. H. W.*. (24 May 2017). Investigation of Drug Cocktail Effects on Cancer Cell-Spheroids Using a Microfluidic Drug-Screening Assay. Micromachines. 8/6. 167 .
  • Zhu, Xiaolu. , Gojgini, Shiva. , Chen, Ting-Hsuan. , Fei, Peng. , Dong, Siyan. , Ho, Chih-Ming. & Segura, Tatiana*. (3 Apr 2017). Directing Three-dimensional Multicellular Morphogenesis by Self-organization of Vascular Mesenchymal Cells in Hyaluronic Acid Hydrogels. Journal of Biological Engineering. 11. 12 .
  • Xu, Ting. , Lam, Miu Ling*. & Chen, Ting-Hsuan*. (20 Feb 2017). Discrete Element Model for Suppression of Coffee-Ring Effect. Scientific Reports. 7. 42817 .
  • Sun, Baoce. , Chen, Ting-Hsuan. & Lam, Raymond H. W.*. (20 Jan 2017). Preferred Cell Alignment along Concave Microgrooves. RSC Advances. 7. 6788 - 6794.
  • Zhu, Xiaolu. , Gojgini, Shiva. , Chen, Ting-Hsuan. , Teng, Fang. , Fei, Peng. , Dong, Siyan. , Segura, Tatiana. & Ho, Chih-Ming*. (23 Aug 2016). Three Dimensional Tubular Structure Self-assembled by Vascular Mesenchymal Cells at Stiffness Interfaces of Hydrogels. Biomedicine & Pharmacotherapy. 83. 1203 - 1211.
  • Liu, Wei. , Bao, Yuanye. , Lam, Miu Ling. , Xu, Ting. , Xie, Kai. , Man, Hin Sum. , Zhu, Ninghao. , Chan, Edward Y. , Lam, Raymond H. W. & Chen, Ting-Hsuan*. (7 Jul 2016). Nanowire Magnetoscope Reveals a Cellular Torque with Left-Right Bias. ACS Nano. 10/8. 7409 - 7417.
  • Chen, Shan. , Chu, Lok Ting. & Chen, Ting-Hsuan*. (24 May 2016). Colorimetric Detection of Active Botulinum Neurotoxin Using Cu2+ Mediated Gold Nanoparticles Agglomeration. Sensors and Actuators B: Chemical. 235. 563 - 567.
  • Chen, Shan. , Chu, Lok Ting. , Yeung, Pak Piu. , Zhao, Zichen. , Bao, Yuenye. , Chan, Miu Shan. , Lo, Pik Kwan. & Chen, Ting-Hsuan*. (2 Oct 2015). Enzyme-Free Amplification by Nano-“Sticky Balls” for Visual Detection of ssDNA/RNA Oligonucleotides. ACS Applied Materials & Interfaces. 7/41. 22821 - 22830.
  • Zhao, Zichen. , Chen, Shan. , Ho, John. Kin Lim. , Chieng, Ching-Chang. & Chen, Ting-Hsuan*. (20 Aug 2015). Visual Detection of Nucleic Acids Based on Mie Scattering and Magnetophoretic Effect. Analyst. 140/23. 7831 - 8058.
  • Lam, Miu Ling. , Chen, Bin. & Chen, Ting-Hsuan*. (2 Mar 2015). Optimization of Combinatory Nicking Endonucleases for Accurate Identification of Nucleic Acids in Low Abundance. Journal of Laboratory Automation. 20. 411 - 417.
  • Li, Yuanhang. , Zhao, Zichen. , Lam, Miu Ling. , Liu, Wei. , Chieng, Ching-Chang. & Chen, Ting-Hsuan*. (16 Sep 2014). Hybridization-Induced Suppression of Coffee Ring Effect for Nucleic Acid Detection. Sensors and Actuators B: Chemical. 206. 56 - 64.
  • Chen, Ting-Hsuan*. (May 2014). Tissue Regeneration: From Synthetic Scaffolds to Self-organizing Morphogenesis. Current Stem Cell Research & Therapy. 9. 432 - 443.
  • Guo, Yina. , Chen, Ting-Hsuan. , Zeng, Xingjuan. , Warburton, David. , Bostrom, Kristina. I. , Ho, Chih-Ming. , Zhao, Xin*. & Garfinkel, Alan*. (18 Nov 2013). Branching Patterns Emerge in a Mathematical Model of The Dynamics of Lung Development. The Journal of Physiology. 592. 313 - 324.
  • Wong, Margaret. , Nguyen, Timothy. , Chen, Ting-Hsuan. , Hsu, Jeffrey. , Zeng, Xingjuan. , Saw, Aman. , Demer, Eric. L. , Zhao, Xin. , Tintut, Yin. & Demer, Linda. L.*. (12 Oct 2012). Preferred Mitotic Orientation in Pattern Formation by Vascular Mesenchymal Cells. American Journal of Physiology - Heart and Circulatory Physiology. 303. H1411 - H1417.
  • Chen, Ting-Hsuan. , Zhu, Xiaolu. , Pan, Leiting. , Zeng, Xingjuan. , Garfinkel, Alan. , Tintut, Yin. , Demer, Linda. L. , Zhao, Xin. & Ho, Chih-Ming*. (23 Sep 2012). Directing Tissue Morphogenesis via Self-Assembly of Vascular Mesenchymal Cells. Biomaterials. 33. 9019 - 9026.
  • Chen, Ting-Hsuan. , Guo, Chunyan. , Zhao, Xin*. , Yao, Yucheng. , Bostrom, Kristina. I. , Wong, Margaret. , Tintut, Yin. , Demer, Linda. L. , Ho, Chih-Ming. & Garfinkel, Alan*. (28 Mar 2012). Patterns of Periodic Holes Created by Increased Cell Motility. Interface Focus. 2. 457 - 464.
  • Chen, Ting-Hsuan. , Hsu, Jeffrey. , Zhao, Xin. , Guo, Chunyan. , Wong, Margaret. , Huang, Yi. , Li, Zongwei. , Garfinkel, Allen. , Ho, Chih-Ming. , Tintut, Yin. & Demer, Linda. L.*. (17 Feb 2012). Left-Right Symmetry Breaking in Tissue Morphogenesis via Cytoskeletal Mechanics. Circulation Research. 110. 551 - 559.
  • Wong, Tak Sing. , Chen, Ting-Hsuan. , Shen, Xiaoyin. & Ho, Chih-Ming*. (2 Feb 2011). Nanochromatography Driven by the Coffee Ring Effect. Analytical Chemistry. 83. 1871 - 1873.
  • Garcia, Daniel. E. , Chen, Ting-Hsuan. , Wei, Fang. & Ho, Chih-Ming*. (1 Jun 2010). A Parametric Design Study of an Electrochemical Sensor. Journal of Laboratory Automation. 15. 179 - 188.
  • Chen, Ting-Hsuan. , Chuang, Yun-Ju. , Chieng, Ching-Chang. & Tseng, Fan-Gang*. (6 Feb 2007). A Wettability Switchable Surface by Microscale Surface Morphology Change. Journal of Micromechanics and Microengineering. 17. 489 - 495.

Book Chapter

  • Madrid, Rossana E. , Chehín, Rosana. , Chen, Ting-Hsuan. & Guiseppi-Elie, Anthony. (11 Jan 2017). BIOSENSORS AND NANOBIOSENSORS. Further Understanding of the Human Machine: The Road to Bioengineering. (pp. 391 - 462). World Scientific. 978-981-3147-26-3. doi:10.1142/9789813147263_0011


Service in CityU


Administrative Assignment

  • Sep 2018 - Aug 2020, College Validation and Monitoring Committee , Member.
  • Jul 2018 - Now, BEBME Program Committee, Program Leader.
  • Jul 2018 - Aug 2021, Departmental Advisory Committee, Members.
  • Jul 2018 - Now, MSBME Program Committee, Member.
  • Jul 2015 - Jun 2018, BEBIE Program Committee, Deputy Program Leader.
  • Jul 2015 - Now, Departmental Executive Committee, Member.
  • Jun 2014 - Now, Departmental Student Affairs Coordination, Deputy Coordinator.
  • Jul 2013 - Jun 2018, MSATM Program Committee, Member.


Last update date : 02 Dec 2022