Chung Tin is currently an Associate Professor in Department of Biomedical Engineering at City University of Hong Kong. He received his BEng. degree (1st Class) from University of Hong Kong in Mechanical Engineering in 2002. He then moved to the United States and obtained his S.M. and PhD. degrees, both in Mechanical Engineering, from Massachusetts Institute of Technology, in 2004 and 2011, respectively. He continues as a postdoctoral associate in MIT until he returned to Hong Kong in 2012. He has been awarded Croucher Foundation Scholarship (HK), American Heart Association Predoctoral Fellowship, and Early Career Award (Research Grant Council, Hong Kong). His research interests include neural prosthetic systems, brain-machine interface, neural computation and sensorimotor learning and control.
Awards and Achievements
- 2021 “Silver Medal” Invention Geneva Evaluation Days (IGED 2021) . Neural Motor prosthesis Prototype for the Restoration of Motor Function in Spinocerebellar Ataxia (Dr MA Chi-Him Eddie, Dr Gajendra KUMAR, Dr. TIN Chung).
- 2013 “Early Career Award” Research Grant Council, Hong Kong SAR.
- 2008 “Predoctoral Fellowship” American Heart Association .
- 2009 “President Award” XIth Oxford Conference on Modeling and Control of Breathing.
- 2002 “The Croucher Foundation Scholarship” Croucher Foundation, Hong Kong.
- 2002 “Sir Edward Youde Memorial Scholarship” Sir Edward Youde Memorial Fund, Hong Kong.
Previous Experience
- Jun 2011 - Jun 2012, Postdoctoral Associate, Harvard/MIT Division of Health Science and Technology, MIT.
Journal
- Zhou, Zhanhong. , Yip, Hei Matthew. , Tsimring, Katya. , Sur, Mriganka. , Ip, Jacque Pak Kan*. & Tin, Chung*. (2023). Effective and efficient neural networks for spike inference from in vivo calcium imaging. Cell Reports Methods. doi:https://doi.org/10.1016/j.crmeth.2023.100462
- Cui, C.Y. , Lau, C.-H. , Chu, L.T. , Kwong, H.K. , Tin, C. & Chen, T.-H.*. (2023). Multimodal detection of flap endonuclease 1 activity through CRISPR/Cas12a trans-cleavage of single-strand DNA oligonucleotides. Biosensors and Bioelectronics. 220. 114859 .
- Xiao, N. , Wu, G.Y. , Zhou, Z.H. , Yao, J. , Wu, B. , Sui, J.F. & Tin, C.*. (2023). Positive feedback of efferent copy via pontine nucleus facilitates cerebellum-mediated associative learning. Cell Reports. 42(2). 112072 .
- Li, X.T. , Koh, K.H. , Xue, J.Q. , So, C.H. , Xiao, N. , Tin, C. & Lai, K.W.C.*. (2022). 1D-2D nanohybrid-based textile strain sensor to boost multiscale deformative motion sensing performance. Nano Research. 15(9). 8398 - 8409.
- Wang, F. , Liu, L.S. , Li, P. , Lau, C.-H. , Leung, H.M. , Chin, R.Y. , Tin, C. & Lo, P.K.*. (2022). Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery. Materials Today Bio. 15. 100299 doi:https://doi.org/10.1016/j.mtbio.2022.100299
- Kumar, G. , Asthana, P. , Yung, W.H. , Kwan, K.M. , Tin, C. & Ma, C.H.E.*. (2022). Deep Brain Stimulation of the Interposed Nucleus Reverses Motor Deficits and Stimulates Production of Anti-inflammatory Cytokines in Ataxia Mice. Molecular Neurobiology. 59(7). 4578 - 4592.
- Chik, Gary Kwok Ki#. @. , Xiao, Na#. @. , Ji, Xudong. , Tsang, Anderson Chun On. , Leung, Giberto Ka Kit. , Zhang, Shiming. , Tin, Chung*. & Chan, Paddy Kwok Leung*. (2022). Flexible Multichannel Neural Probe Developed by Electropolymerization for Localized Stimulation and Sensing. Advanced Materials Technologies. 7(8). 2200143 .
- Jiang, S. , Wang, Y.-S. , Zheng, X.-X. , Zhao, S.-L. , Sun, L. , Chen, P.-H. , Zhou, Y. , Tin, C. , Li, H.-L. , Sui, J.F.*. & Wu, G.Y.*. (2022). Itch-specific neurons in the ventrolateral orbital cortex selectively modulate the itch processing. Science Advances. 8(30). eabn4408 doi:https://doi.org/10.1126/sciadv.abn4408
- Lau, C.-H. , Huang, S.P. , Lam, R.H.W. & Tin, C.*. (2022). PAM-flexible dual base editor-mediated random mutagenesis and self-activation strategies to improve CRISPRa potency. Molecular Therapy-Methods & Clinical Development. 26. 26 - 37.
- Zhou, Z.H. , Zhai, X.L. & Tin, C.*. (2021). Fully automatic electrocardiogram classification system based on generative adversarial network with auxiliary classifier. Expert Systems with Applications. 174. 114809 doi:10.1016/j.eswa.2021.114809
- Leung, H.M.#. @. , Lau, C.-H.#. @. , Ho, J.-W. , Chan, M.S. , Chang, T.J.H. , Law, L.H. , Wang, F. , Tam, D.Y. , Liu, L.S. , Chan, K.W.Y. , Tin, C.*. & Lo, P.K.*. (2021). Targeted Brain Tumor Imaging by Using Discrete Biopolymer-Coated Nanodiamonds across the Blood Brain Barrier. Nanoscale. 13(5). 3184 - 3193.
- Lau, C.-H. , Tin, C. & Suh, Y. (2020). CRISPR-based strategies for targeted transgene knock-in and gene correction. Faculty Reviews. 9(28). 20 .
- Tam, D.Y.#. @. , Ho, J.-W.#. @. , Chan, M.S. , Lau, C.-H. , Chang, T.J.H. , Leung, H.M. , Liu, L.S. , Wang, F. , Chan, L.L.H. , Tin, C.*. & Lo, P.K.*. (2020). Penetrating the Blood–Brain Barrier by Self-Assembled 3D DNA Nanocages as Drug Delivery Vehicles for Brain Cancer Therapy. ACS Applied Materials and Interfaces. 12(26). 28928 - 28940.
- Zhai, X.L. , Zhou, Z.H. & Tin, C,*. (2020). Semi-Supervised Learning for ECG Classification without Patient-specific Labeled Data. Expert Systems with Applications. 158. 113411 .
- Wang, F. , Liu, L.S. , Lau, C.-H. , Chang, T.J.H. , Tam, D.Y. , Leung, H.M. , Tin, C.*. & Lo, P.K.*. (2019). Synthetic α-L-Threose Nucleic Acids Targeting BcL-2 Show Gene Silencing and in Vivo Antitumor Activity for Cancer Therapy. ACS Applied Materials and Interfaces. 11(42). 38510 - 38518.
- Lau, Cia-Hin. , Ho, Jonathan Ho-Thim. , Lo, Pik Kwan. & Tin, Chung*. (2019). Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa. Molecular Therapy - Nucleic Acids. 16. 637 - 649. doi:doi.org/10.1016/j.omtn.2019.04.015
- Lau, Cia Hin*. & Tin, Chung. (2019). The Synergy between CRISPR and Chemical Engineering. Current Gene Therapy. 19(3). 147 - 171.
- Cui, X. , Liu, Y. , Hu, D. , Qian, W. , Tin, C. , Sun, D. , Chen, W. & Lam, R.H.W. (2018). A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification. Lap On a Chip. 18(3). 522 - 531.
- Zhai, Xiaolong. & Tin, Chung*. (2018). Automated ECG Classification using Dual Heartbeat Coupling based on Convolutional Neural Network. IEEE Access. 6. 27465 - 27472. doi:10.1109/ACCESS.2018.2833841
- HU, S. , Liu, Y. , Tin, C. & Lam, R.H.W. (2018). Characterization of Cytoskeletal Pore Size Using Quantum Dots. IEEE Transactions on Nanotechnology. 17(3). 298 - 401.
- Leung, H.M. , Chan, M.S. , Liu, L.S. , Wong, S.W. , Lo, T.w. , Lau, C.-H. , Tin, C. & Lo, P.K.*. (2018). Dual-Function, Cationic, Peptide-Coated Nanodiamond Systems : Facilitating Nuclear-Targeting Delivery for Enhanced Gene Therapy Applications. ACS Sustainable Chemistry and Engineering. 6(8). 9671 - 9681. doi:10.1021/acssuschemeng.8b00446
- Xu, Tao#. @. , Xiao, Na#. @. , Zhai, Xiaolong. , Chan, Pak Kwan. & Tin, Chung*. (2017). Real-time Cerebellar Neuroprosthetic System based on a Spiking Neural Network Model of Motor Learning. Journal of Neural Engineering. 15(1). 016021 doi:10.1088/1741-2552/aa98e9
- Zhai, Xiaolong. , Jelfs, Beth. , Chan, Rosa H.M. & Tin, Chung*. (2017). Self-Recalibrating Surface EMG Pattern Recognition for Neuroprosthesis Control Based on Convolutional Neural Network. Frontiers in Neuroscience. 11. 379 .
- Tam, Dick Yan. , Dai, Ziwen. , Chan, Miu Shan. , Liu, Ling Sum. , Cheung, Man Ching. , Bolze, Frederic. , Tin, Chung. & Lo, Pik Kwan*. (2016). A Reversible DNA Logic Gate Platform Operated by One- and Two-Photon Excitations. Angewandte Chemie International Edition. 55(1). 164 - 168.
- Au, N.P. , Kumar, G. , Asthana, P. , Tin, C. , Mak, Y.L. , Chan, L.L. , Lam, P.K.S. & Ma, C.H. (2016). Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury. Scientific Reports. 6: 26809.
- Chan, Miu Shan. , Tam, Dick Yan. , Dai, Ziwen. , Liu, Ling Sum. , Ho, Jonathan Weng-Thim. , Chan, Man Lee. , Xu, Di. , Wong, Man Shing. , Tin, Chung*. & Lo, Pik Kwan*. (2016). Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers. Small. 12(6). 770 - 781.
- Luo, J. , Coapes, G. , Mak, T. , Yamazaki, T. , Tin, C.*. & Degenaar, P.*. (2016). Real-Time Simulation of Passage-of-Time Encoding in Cerebellum Using a Scalable FPGA-based System. IEEE Trans. Biomedical Circuits and Systems. 10(3). 742 - 753.
- Song, G. , Tin, C. & Poon, C.-S.*. (2015). Multiscale fingerprinting of neuronal functional connectivity. Brain Structure and Function. 220(5). 2967 - 2982.
- Poon, C.-S.*. , Tin, C. & Song, G. (2015). Submissive hypercapnia: Why COPD patients are more prone to CO2 retention than heart failure patients. Respiratory Physiology and Neurobiology. 216. 86 - 93.
- Poon, C.-S.*. & Tin, C. (2013). Mechanism of augmented exercise hyperpnea in chronic heart failure and dead space loading. Respiratory Physiology and Neurobiology. 186(1). 114 - 130.
- Tin, C. , Song, G. & Poon, C.-S.*. (2012). Hypercapnia attenuates inspiratory amplitude and expiratory time responsiveness to hypoxia in vagotomized and vagal-intact rats. Respiratory Physiology and Neurobiology. 181(1). 79 - 87.
- Song, G. , Tin, C. , Giacometti, M. & Poon, C.-S.*. (2011). Habituation without NMDA receptor-dependent desensitization of Hering-Breuer apnea reflex in a mecp2+/- mutant mouse model of Rett syndrome. Frontiers in Integrative Neuroscience. 5:6 .
- MacDonald, S.#. @. , Tin, C.#. @. , Song, G. & Poon, C.-S.*. (2009). Use-Dependent Learning and Memory of Hering-Breuer Inflation Reflex in Rat. Experimental Physiology. 94(2). 269 - 278.
- Poon, C.-S.*. , Tin, C. & Yu, Y. (2007). Homeostasis of exercise hyperpnea and optimal sensorimotor integration: The internal model paradigm. Respiratory Physiology and Neurobiology. 159(1). 1 - 13.
- Tin, C. & Poon, C.-S.*. (2005). Internal Models in Sensorimotor Integration: Perspectives from Adaptive Control Theory. Journal of Neural Engineering. 2(3). S147 - 163.
Conference Paper
- Zhou, Zhanhong. , Zhai, Xiaolong. & Tin, Chung. (2018). A Cerebellar Spiking Neural Model for Phase Reversal of Vestibulo-ocular Reflex. 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Honolulu, HI. USA: doi:10.1109/EMBC.2018.8513671
- Jelfs, B. , Li, L. , Tin, C. & Chan, R. H.-M. (2016). Fuzzy Entropy Based Nonnegative Matrix Factorization For Muscle Synergy Extraction. ICASSP. Shanghai. China: .
- Zhai, X. , Jelfs, B. , Cahn, R. H.-M. & Tin, C. (2016). Short latency hand movement classification based on surface EMG spectrogram with PCA. 38th Annual International IEEE EMBS Conference. Florida. USA: .
- Jelfs, B. , Zhou, S. , Wong, B. K. Y. , Tin, C. & Chan, R.H.M. (2015). Recruitment of Small Synergistic Movement Makes a Good Pianist. 37th Annual International IEEE EMBS Conference. Milan. Italy: .
- Luo, J. , Coapes, G. , Degenaar, P. , Yamazaki, T. , Mak, T. & Tin, C. (2014). A real-time silicon cerebellum spiking neural model based on FPGA. 14th International Symposium on Integrated Circuits (ISIC). (invited). Singapore: .
- Luo, J. , Coapes, G. , Mak, T. , Yamazaki, T. , Tin, C. & Degenaar, P. (2014). A Scalable FPGA-based Cerebellum for Passage-of-Time Representation. 36th Annual International IEEE EMBS Conference. Chicago. USA: .
- Song, G. , Tin, C. & Poon, C.-S. (2010). Bilateral lesions of pontine k̈lliker-fuse nuclei provoke apnea instead of apneusis in anesthetized adult rat. Adv. Exp. Med. Biol. 669. (pp. 185 - 188). Nara. Japan: .
- Tin, C. , Wasserman, K.W. , Cherniack, N.S. & Poon, C.-S. (2010). Paradoxical Potentiation of Exercise Hyperpnea in Congestive Heart Failure Contradicts Sherrington Chemoreflex Model and Supports a Respiratory Optimization Model. Adv. Exp. Med. Biol. 669. (pp. 69 - 72). Nara. Japan: .
- Feng, J. , Tin, C. & Poon, C.-S. (2009). A Dual Adaptive Control Theory Inspired by Hebbian Associative Learning. Proceedings of the IEEE Conference on Decision and Control. (pp. 4505 - 4510).
Book Chapter
- Tin, C. & Poon, C.-S. (2014). Control of Breathing, Integration of Adaptive Reflexes. Encyclopedia of Computational Neuroscience. Springer.
- Chan, R. H.-M. , Mak, T. & Tin, C. (2014). Computational Models and Hardware Implementations for Real-Time Neuron–Machine Interactions. Neural Computation, Neural Devices, and Neural Prosthesis. (pp. 289 - 311). Springer.
- Tin, C. & Poon, C.-S. (2013). Integrative and Reductionist Approaches to Modeling of Control of Breathing. Mathematical Modeling and Validation in Physiology: Applications to the Cardiovascular and Respiratory Systems. (pp. 89 - 103). Springer Berlin Heidelberg.
External Services
Professional Activity
- 2016 - 2017, Chairman, IEEE EMBS Hong Kong-Macau Joint Chapter.
Opening
- PhD student
We are looking for highly motivated PhD students with research experience/background in engineering (in particular machine learning, signal processing, system integration and computational neuroscience). and/or neuroscience (in particular electrophysiology and animal behavorial training)
The minimum English proficiency requirements are:
a) a minimum TOEFL score of 550 (paper-based) or 79 (internet-based); or
b) a minimum overall band score of 6.5 in IELTS;
To apply, please send your CV and transcripts with a brief description of your research experience/interest to Dr. Chung TIN (chungtin@cityu.edu.hk).
Further information about admission to our PhD program can be found at
http://www.sgs.cityu.edu.hk/prospective/rpg/
Research Assistant
We are looking for highly motivated RA with strong background in machine learning, image processing and/or computer vision system.
Bachelor/Master from an accredited institution from one of the following disciplines: Electrical and Electronic Engineering, Information Engineering, Computer Engineering, Computer Science. Applicants must have strong experience in programming in related area of computer vision and machine learning. Candidates experienced in hardware development board/embedded system are prefereed. Candidates should be highly self-driven, innovative, and have excellent written and oral communication skills in English.
To apply, please send your CV and transcripts with a brief description of your research experience/interest to Dr. Chung TIN (chungtin@cityu.edu.hk).
Lab Member
- Current Members:
Postdoc / Research Fellow
Dr. XIAO Na
Postdoc Fellow
PhD in Biomedical Engineering, City University of Hong Kong, Hong Kong SAR
MSc in Medical Science, Nanjing Medical University, China
Graduate Students
LIU Yingjian
PhD Student (Sept 2021)
M.E. in Electronic Science and Technology, Shandong University, Jinan, China
B.Eng. in Communication Engineering, University of Jinan, Jinan, China
yingjiliu3-c@my.cityu.edu.hk
GUO Kejiang
PhD Student (Aug 2022)
M. Sc. in Biomedical Engineering, Chinese University of Hong Kong, Hong Kong SAR
B.Eng. in Telecommunicaiton Engineering, Sichuan University, China
kejianguo3-c@my.cityu.edu.hk
WU Shibin
PhD Student (Aug 2023)
M. E. in n Electronic and Communication Engineering, South China University of Technology, China
B.Eng. in Electronic and Communcation Engineering, South China University of Technology, China
shibinwu2-c@my.cityu.edu.hk
LYU Xiaoqing
PhD Student (Aug 2023) (Joint PhD CityU-Xi'an Jiaotong University)
M.E. in Electrical Engineering, Xi'an Jiaotong University, China
B.Eng in Mechanical Design & Manufacturing and Automation, Shandong University of Science and Technology, China
lyu.xiaoqing@my.cityu.edu.hk
Research Assistant
CHO King Yi Judy
BSc. in Biochemistry and Cell Biology, Hong Kong University of Science and Technology
kingcho@cityu.edu.hk
UG Student Helper
ZHUO Caiyi Charlene (CityU BME)
- Alumni:
LUO Jun-Wen, Ryan (Visiting Research Assistant, April 2013 - Oct 2013)
PhD in Electrical & Electronic Engineering, Newcsatle University (Expected in 2014)
ZHANG Jia-Yao, Edi (Undergraduate Technical Assistant, Jun 2013 - Aug 2013)
BEng in Information Engineering, City University of Hong Kong (Expected in 2015)
DING Kaile (Undergraduate Technical Assistant, Jan 2014 - June 2014)
BEng in Electrical & Communication Engineering, City University of Hong Kong (2014)
(Pursuing Master Degree in Univesity of Michigan)
LEE Ka-Chun (Undergraduate Technical Assistant, Sept 2013 - Sept 2014)
BEng in Civil & Structural Engineering, City University of Hong Kong (Expected in 2015)
Dr. Nayan Kakoty (Postdoctoral Fellow, Nov 2014 - Feb 2015)
YAM Sau-Ching (Undergraduate Technical Assistant, Jan 2015 - Aug 2015)
BEng in Bioengineering, City University of Hong Kong
FUNG Cheuk-Wang (Alex) (Undergraduate Technical Assistant, June 2014 - Aug 2016)
BEng in Bioengineering, City University of Hong Kong
YIP Chun-Kit (CK) (Undergraduate Technical Assistant, June 2014 - Aug 2016)
BEng in Bioengineering, City University of Hong Kong
CHAN Ka-Wai (Undergraduate Technical Assistant, Aug 2015 - Aug 2016)
BEng in Mechatronicl Engineering, City University of Hong Kong
CHAN Pak-Kwan (Research Assistant, Aug 2016 - Sept 2017)
BEng in Mechatronicl Engineering, City University of Hong Kong
XU Tao (PhD Student, 2014-2019)
ZHAI Xiaolong (PhD Student, May 2015 - Jun 2019, Currently AI Engineer in Tencent)
XIAO Na (PhD Student, May 2015 - Aug 2019)
Dr. Jonathan HO (Research Fellow, 2014-2019)
CHU Kai Him Lawrence (Research Assistant, 2020-2021, Currently PhD. student in Case Western Reserve University)
HO Yuen Shan Sharon (Student Intern June-Aug 2021, Currently a student in MBBS and intercalating in Masters in Engineering (Bioengineering and Information Engineering) at University of Cambridge, UK)
LAU Cia-HIn (PhD Student 2017-2021, Hong Kong PhD Fellowship, Curently Senior R&D Scientist at a startup biotech company)
ZHOU Zhanhong (PhD Student 2017-2022, Currently Machine Learning Engineer in Huawei Noah’s Ark Lab Hong Kong)
- Final Year Project Students:
2018-2019
Comparative Study of Supervised Learning Algorithms in Predicting Readmission in Diabetic Patients
Students: LAM Yan Lok, LEE Pang Kam, UTOMO William Budi
2017-2018
Engineered adeno-associated virus serotype for neuronal-specific transduction of the CRISRP/Cas9 complex
Students: SIN Chak Yeung, MA Hoi Ching, TAM Tze Hei, LI Hui Ching
2016-2017
Touch-free biomedical image navigation system for surgeons
Students: WONG Chun Yin, LEUNG Yin, LO Karen
EMG-driven prosthetic hand with force feedback
Students: CHAN Ka Yu, CHENG Charlie, OR Ming Ho
Exhibition at Gerontech and Innovation Expo cum Summit 2017, Hong Kong
2015-2016
EMG-driven rehabilitation robotic hand
Students: YAU Hoi Yi, WONG Hau Ching, O Ka Ying, HUANG Yu-Hsuan, MAK Kwan Yi
Silver Award of the “HKEIA Innovation & Technology Project Competition Award: For Students of Electronic Engineering or Related Engineering Fields 2016”
2013-2014
Development of a EEG-based mobile apps for attention training in ADHD
Student: WU Chik Wai
Last update date :
21 Nov 2023
