This course enables postgraduate students to have a general knowledge of nanoscience from nanohistory, nanofabrication, characterization and corresponding applications. Special focus will be on bottom-up wet chemistry preparation and post treatments (e.g. phase transfer/surface modification) of nanoparticles ranging from metal, metal oxide to quantum dot and their property-directed applications. Most importantly, students will be able to explain some phenomena observed in nanoscience by what they have learned in inorganic chemistry (e.g. ligand-chelating, HOMO-LUMO tuning…) and physical chemistry (e.g. colloidal and surface chemistry, flocculation state, thermodynamic/kinetic control, quantum confinement…). In addition, nanobiotechnology has become an emerging interdisciplinary area in this field for researching and solving biological phenomena and problems using nanochemistry and nanomaterials. For example, nanomaterials can serve as signalling nanoprobes, nanotools that manipulate mechanical forces, and vehicles that deliver drugs or biomolecules. A brief and intuitive introduction of nanomaterials and the characteristics and applications of nanobiotechnology will be presented at a level accessible to graduate students interested in nanomedicine, materials science, nanochemistry, and nanomaterials.