A biomaterial different from a biological material is any substance that is engineered to interact with biological systems for biomedical and medical purposes - either therapeutic or diagnostic. Advanced biomaterials refer to those with novel properties, multi-functions smart features high-performance characteristics and for more demanding applications or for improved outcomes and by different mechanisms. The science of biomaterials encompasses elements of medicine biology chemistry physics, tissue engineering materials science and engineering. This course is a lecture-intensive and project-based class. Topics include conceptual fundamentals and general theories, materials design fabrication, device evaluation and their functional mechanisms as well as applications in healthcare and biomedical areas.