Flexible bioelectronics is the application of multidisciplinary principles to biology, medicine and human healthcare. Since biological tissues are very soft, which are typically six orders of magnitude to the existing bio-instrumentation, thus, results in disadvantages such as irritating, inconvenient and invasive for nowadays diagnosis and treatment methods. Combining advantages of desire “soft” materials, optimized device design, reliable system, the technology of flexible bioelectronics enables development of innovative devices or processes, such as skin-like sensors, for prevention, diagnosis, monitoring and treatment of disease.