Biochemistry investigates chemical principles in living cells. This course aims to provide students with an overview of fundamental principles and basic knowledge in biochemistry. Topics include the structure and function of biomolecules, enzyme functions, metabolic pathways of carbohydrates, fatty acids and proteins, biosignaling pathways, biomembranes and important techniques in biochemistry. In particular, students will acquire in-depth knowledge about the chemical structure of biomolecules involved in mammalian metabolism, the concepts in biochemical reactions involved in metabolism, the principles behind the free energy flow in several major metabolic pathways and the interaction and regulation between different metabolic pathways. Another important aspect of this course will be linking the knowledge in biochemistry to human diseases. Biochemical pathways involved in important human diseases will be explored. The knowledge acquired from this course will become the foundation for studying many other biomedical subjects.