This course enables students of postgraduate level to more in-depth understand concepts and principles of advanced chemical instrumentation (electron, vibration and NMR spectroscopies and mass spectrometry) applied for a wide variety of advanced chemistry disciplines (such as catalysis, synthetic chemistry, materials & biomaterials chemistry, analytical & bio-analytical sciences, computational chemistry, environmental chemistry and chemical biology). Through review and discussion on some recent literature, the latest instrumental developments will be introduced to students, and their advantages, limitations and challenges for chemical research and development will also be critically evaluated. Individual literature review will allow students to identify nowadays chemical problems and propose plausible usages of the advanced instrumentation to obtain chemical information to tackle the problems. On completion of this course, students should be able to design experiments with application of most appropriate instrumental tools or their combination to solve problems in chemistry and molecular sciences.