This course will provide students a comprehensive overview of different concepts and tools used in disease prediction, diagnosis, prevention and optimal treatment planning. The first focus area will emphasize the role of diagnostic imaging in detecting molecules, genes, and cells. Emphasis will be placed on how these techniques can help study molecular mechanisms of disease in vivo. Topics include nuclear imaging techniques: PET, SPECT; molecular MRI and optical imaging methods, targeted probes, molecular imaging in the context of cancer and infectious diseases. The second focus areas will include molecular diagnostics including nucleic acid techniques, OMICS, rapid molecular diagnostics in cancer and infectious disease testing and precision medicine. Introduction to basics of radiomics and AI in diagnosis will also be included. Following the completion of the course, students will have built a strong foundation for future exploration and study in molecular diagnostics.