Faculty Profile
YANG, Mengsu (Michael)

YANG, Mengsu (Michael) (楊夢甦)

Yeung Kin Man Chair Professor of Biomedical Sciences

Senior Vice-President (Innovation and Enterprise)

Director (Tung Biomedical Sciences Centre)

Fellow, US National Academy of Inventors

PhD (Toronto)

Professor Michael Yang is currently Senior Vice-President (Innovation and Enterprise), Yeung Kin-Man Chair Professor (Biomedical Sciences), and Director of the Tung Biomedical Sciences Centre of City University of Hong Kong (CityU). Since 1994, he has trained 48 PhD graduates and 36 postdoctoral fellows, published more than 300 peer-reviewed scientific papers, received/filed over 60 US/China patents, and was listed among the top 2% of the world’s most highly cited scientists from 2020 to 2024. He has co-founded several biotech companies based on technologies developed in CityU, including Genetel, Prenetics and Cellomics, benefiting millions of patients. Professor Yang is responsible for CityU’s “HK Tech 300” initiative, the leading university-based entrepreneurship program in Asia, with the aims to promote technology transfer and commercialization, and to nurture young talents in innovation and entrepreneurship. Since 2020, “HK Tech 300” has incubated more than 700 startups, and expanded to Mainland China and Southeast Asia, making significant contribution to developing Hong Kong into an international hub of innovation and technology.

Prof. Yang holds honorary professorships at Zhejiang University, the Army Medical University, and the Institute of Microsystems of the Chinese Academy of Science, and serves in the board of the Asian Fund for Cancer Research, and the scientific advisory board of the government-funded Hong Kong Genome Centre. He is also a member of the Research Grants Council, the Health and Medical Research Fund, and the Innovation and Technology Fund, and the Hetao Shenzhen-Hong Kong Innovation and Collaboration Zone Experts Consultative Committee. He was awarded the “Chunhui Scholar Award” by the Ministry of Education of China in 2003, the “K. C. Wong Foundation Award” in 2004, the “Shenzhen Science and Technology Innovation Award” in 2006, the “Hong Kong Technological Achievement Grand Award” in 2007, the “Natural Science Award Second-Class” from the Ministry of Education in 2015, the “Wuxi AppTech Life Science and Chemistry Award” in 2016, and a Gold Medal at the 47th International Exhibition of Inventions of Geneva in 2019. In 2024, Prof. Yang was elected a Fellow of the US National Academy of Inventors (NAI), in recognition of his significant contributions to innovation, societal welfare, and economic development.

楊夢甦教授現任香港城市大學（城大）高級副校長、楊建文冠名生物醫學講座教授、以及董氏生物醫學中心主任。他從1994年迄今指導了48位博士畢業生及36位博士後研究員，在國際期刊共發表300多篇論文及獲得逾60項美國及中國專利，2020–2024年連續獲評為被高度引用的全球頂尖2%科學家。他還先後參與創辦了多家基於城大專利技術的生物科技公司，包括港龍生物、Prenetics及晶准醫學，科研成果惠及數以百萬計的患者。楊教授主持的城大 “HK Tech 300” 計畫，致力於科研成果的轉化及培養年輕創科人才，是亞洲領先的大學創新創業計畫。“HK Tech 300”從2020年迄今已培育逾七百個初創公司，並拓展到內地及東南亞，助力香港成為國際創新科技中心。

楊教授是浙江大學、陸軍軍醫大學、中國科學院微系統所榮譽教授，以及亞洲癌症研究基金會董事、香港基因組中心顧問。他還兼任香港特區政府研究資助局理事會、醫療衛生研究基金、創新科技基金、深港創新合作區專家委員會成員。楊教授曾獲2003年王寛誠教育基金會學者獎、2004年教育部「春暉學者」獎、2006年深圳市創新科技獎、2007年香港工商業獎科技成就大獎、2015年教育部自然科學二等獎、2016年科技部藥明康德生命化學獎、及2019年日內瓦國際發明展金獎。2024年楊教授榮膺美國國家發明家科學院 (National Academy of Inventors) 院士，以表彰他對創新科技、經濟發展及社會福祉作出的卓越貢獻。

Media Reports

Representative Publications

Microfluidics for Cell Analysis

  • “Automatic high-throughput and non-invasive selection of sperm at the biochemical level”, Med, 2024, 5, 1–19.
  • “Extracellular vesicle preparation and analysis: a state-of-the-art review”, Advanced Science, 2024, 2401069.
  • “An integrated and multi-functional droplet-based microfluidic platform for digital DNA amplification”, Biosensors and Bioelectronics, 2024, 246, 115831.
  • High Throughput Confined Migration Microfluidic Device for Drug Screening, Small, 2023, 2207194.
  • Dually stimulative single-chain polymeric nano lock with dynamic ligands for sensitive detection of circulating tumor cells, Biosensors and Bioelectronics, 2022, 217, 114692.
  • Single Cell Analysis of Mechanical Properties and EMT-related Gene Expression Profiles in Cancer Fingers, iScience, 2022, 25(3), 103917.
  • Microdissected ‘cuboids’ for microfluidic drug testing of intact tissues, Lab on a Chip, 2021, 21, 122-142.
  • Single cell target gene mutation analysis by arc-edge-channel monolithic valve microfluidic cell isolation and locked nucleic acid based PCR detection, Sensors and Actuators B: Chemical, 2019, 293, 224-234.
  • Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007-2017), Analytica Chimica Acta, 2018, 1044, 29-65.
  • Electrotaxis of cancer stem cells is associated with both activation of stretch-activated cation channels and internal calcium release, Bioelectrochemistry, 2018, 124, 80-92.
  • Cell migration microfluidics for electrotaxis-based heterogeneity study of lung cancer cells, Biosensors and Bioelectronics, 2017, 89, 837-845.
  • Microfluidic platform for studying chemotaxis of adhesive cells revealed a gradient-dependent migration and acceleration of cancer stem cells, Analytical Chemistry, 2015, 87(14), 7098-7108.
  • A microfluidic linear node array for the study of protein-ligand interaction, Lab Chip, 2014, 14, 3993-3999.
  • Single layer linear array of microbeads for multiplexed analysis of DNA and proteins, Biosensors and Bioelectronics, 2014, 54, 297-305.
  • Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells, Lab on a Chip, 2013, 13, 1060-1069.
  • Integrated sieving microstructures on microchannels for biological cell trapping and droplet formation, Lab on a Chip, 2011, 11, 3352-3355.
  • Real-time monitoring of cell-cell communications evoked by mechanical stimulation of suspension cells using an integrated microfluidics chip, Lab on a Chip, 2010, 10, 2271-2278.
  • Microfluidic formation of single cell array for parallel analysis of CRAC channel activation and inhibition, Analytical Biochemistry, 2010, 396, 173-179.
  • A microfluidic device with microbead array for sensitive virus DNA detection and genotyping using quantum dots as fluorescence labels, Biosensors & Bioelectronics, 2010, 25, 2402-2407.
  • 3-D streamline steering by nodes arrayed in an entangled microfluidic network, Lab on a Chip, 2007, 7, 1712-1716.
  • Generation of linear and non-linear concentration gradients along microfluidic channel by microtunnel controlled stepwise addition of sample solution, Lab on a Chip, 2007, 7, 1371-1373.
  • Dose-dependent cell-based assays in V-shaped microfluidic channels, Lab on a Chip, 2006, 6, 921-929.
  • Microfluidics technology for manipulation and analysis of biological cells, Analytica Chimica Acta, 2006, 560, 1-23.
  • Hydrodynamic simulation of cell docking in microfluidic channels with different dam structures, Lab on a Chip, 2004, 4, 53–59.
  • Cell docking and on-chip monitoring of cellular reactions under controlled concentration gradient on a microfluidic device, Analytical Chemistry, 2002, 74, 3991-4001.
  • Generation of concentration gradient by diffusive mixing and consecutive dilution in a microfluidic chip, Lab on a Chip, 2002, 2, 158-163.

Cancer Biology & Nanomedicine

  • “Size and shape control of microgel-encapsulating tumor spheroid via a user-friendly solenoid valve-based sorter and its application on precise drug testing”, Biosensors and Bioelectronics, 2024, 264, 116614.
  • “Distinguishing high-metastasis-potential circulating tumor cells through fluidic shear stress in a bloodstream-like microfluidic circulatory system”, Oncogene, 2024, 43, 2295–2306.
  • “Magnetic particle imaging: from tracer design to biomedical applications in vasculature abnormality”, Advanced Materials, 2023, 2306450.
  • Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network, Molecular Cancer, 2023, 22, 21.
  • Three-dimensional Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor-on-a-chip, Advanced Healthy Materials, 2023, 2202609.
  • Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence, Oncogene, 2022, 41(6), 895-906.
  • Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance, Nanomedicine. 2021, 16, 1411–1427.
  • Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ, Oncogene, 2021, 40, 1775–1791.
  • Magnetothermal miniature reactors based on iron oxide nanocubes-coated liquid marbles, Advanced Healthcare Materials, 2021, 2001658 (8 pages).
  • Single-cell EMT-related transcriptional analysis uncovers the intra-cluster heterogeneity of tumor cell clusters in epithelial ovarian cancer ascites, Oncogene, 2020, 39(21), 4227–4240.
  • Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy, Theranostics, 2020, 10(3), 1181-1196.
  • Recent Progress of Ferroptosis Inducers for Cancer Therapy, Advanced Materials, 2019, 1904197, pp25.
  • Efficient RNA drug delivery using red blood cell extracellular vesicles, Nature Communications, 2018, 9(1), 2359 (15 pages).
  • Transparent and gas-permeable liquid marbles for culturing and drug sensitivity test of tumor spheroids, Advanced Healthcare Materials, 2017, 1700185.
  • Chemoresistant lung cancer stem cells display high DNA repair capability to remove cisplatin-DNA damage, British Journal of Pharmacology, 2017, 174(4), 302-313.
  • Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in silicon nanowire microenvironment, Nanomedicine: Nanotechnology, Biology, and Medicine, 2014, 10(6), 1153-63.
  • Reorganization of cytoskeleton and transient activation of Ca2+ channels in mesenchymal stem cells cultured on silicon nanowire arrays, ACS Applied Materials & Interfaces, 2013, 5, 13295−13304.
  • Multienzyme-nanoparticles amplification for sensitive virus genotyping in microfluidic microbeads array using Au nanoparticle probes and quantum dots as labels, Biosensors and Bioelectronics, 2011, 29, 89-96.
  • Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells, ACS Nano, 2010, 4, 6439-6448.
  • Inhibition of proliferation and differentiation of mesenchymal stem cells by carboxylated carbon nanotubes, ACS Nano, 2010, 4(4), pp 2185–2195.
  • COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis, Clinical Cancer Research, 2008, 14 (16), 5061-5068.
  • DNA-directed self-assembly of gold nanoparticles into binary and ternary nanostructures, Nanotechnology, 2007, 18, 015102 (7 pages).
  • Hypoxia induces the activation of human hepatic stellate cells LX-2 activation through TGF-b signaling pathway, FEBS Letters, 2007, 581, 203-210.
  • Clustin plays an important role in hepatocellular carcinoma metastasis, Oncogene, 2006, 25, 1242-1250.
  • Molecular mechanisms of survival and apoptosis in RAW 264.7 macrophages under oxidative stress, Apoptosis, 2005, 10, 545-556.
  • Association of overexpression of vimentin and hepatocellular carcinoma metastasis. Oncogene, 2004, 23, 298-302.

3 March 2025

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