Department of Biomedical Sciences, City University of Hong Kong

1A-209, 2/F, Block 1, To Yuen Building
+852 3442-2812
+852 3442-0549
huiyoyin@cityu.edu.hk
CityU Scholars
Lab Website
Metabolism • metabolomics/lipidomics • atherosclerosis • liver cancer • lipid peroxidation • hyperuricemia and gout • mass spectrometry

Professor Huiyong YIN is currently the tenured Professor of Biomedical Sciences in Metabolism and Metabolic Diseases in the Department of Biomedical Sciences, and Associate Dean (Research) for Jockey Club College of Veterinary Medicine and Life Sciences. He is also a member of the State Key Laboratory of Marine Pollution at City University of Hone Kong (https://www.cityu.edu.hk/sklmp/). Before joining City University of Hong Kong in February 2023, Prof. Yin was a Senior Principal Investigator and Group Leader of Lipid Metabolism in Human Nutrition-related Diseases at Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), Shanghai, China. He was also the Distinguished Adjunct Professor in the School of Life Sciences and Technology in ShanghaiTech University since 2013. He obtained his BSc from Tongji University and MSc from Shanghai Institute of Organic Chemistry (SIOC), CAS, and PhD in Chemistry from Vanderbilt University in 2002. In 2003, Prof. Yin joined Vanderbilt University School of Medicine as a Research Instructor in the Division of Clinical Pharmacology, and was promoted to a Research Assistant Professor in 2005 and Associate Professor in 2008 in the Departments of Pharmacology, Medicine, and Chemistry. He also served as the Director for the Core Laboratory of Drug Metabolism and Pharmacokinetics (DMPK) in the drug discovery program at Vanderbilt University from 2007-2009. In August 2011, Prof. YIN was recruited back to the Institute of Nutritional Sciences (INS), Shanghai Institutes of Biological Sciences (SIBS), CAS, under the global talent recruitment program by Shanghai Municipal Government and CAS. He was the founding director of the Mass Spectrometry Facility for Nutrition and Food Safety at INS, SIBS from 2011 to 2017.

Professor Yin is one of the leading scientists in the field of redox regulation of glucose and lipid metabolism in human metabolic diseases. His research interest has been focusing on the understanding of metabolic reprogramming in carbohydrate and lipid metabolism in metabolic diseases including atherosclerosis, liver cancer, hyperuricemia and gout. For the past 20 years, Prof. Yin has made significant contributions in understanding the roles and underlying mechanisms of free radical lipid peroxidation in human diseases including atherosclerosis using the state-of-the art metabolomics/lipidomics approaches (Yin et al JACS, 2000; 2002; Yin et al Chem. Rev. 2011; Zhong et al, Redox Biol. 2015; Zhong et al, Free Radic. Biol. Med. 2019; Shen et al, Clin. Transl. Med., 2024), and discovered novel non-enzymatic functions of Aldehyde Dehydrogenase 2 (ALDH2) in cardiovascular disease (CVD) (Zhong et al, J. Clin. Invest. 2019; Li et al, JCI Insight, 2021; Zhong et al, Redox Biol. 2021; Zhang et al, Nat. Rev. Cardiol. 2023). His research for the past several years has defined novel pathways in metabolic reprogramming in liver cancer mediated by a key glycolytic enzyme fructose-1,6-bisphosphate aldolase B (ALDOB) (Li et al, Nature Cancer, 2020; He et al, PLoS Biol., 2020; Liu et al, Hepatology, 2021; Yin et al, Hepatology, 2023). Using a precision medicine approach based on metabolomics and machine learning algorithms, Prof. Yin and his collaborators have established prediction models in assessing risks for gout attacks in asymptomatic hyperuricemia patients and the frequencies for gout flares (Shen et al, Arthritis. Rheumatol., 2021; Wang et al, Arthritis. Rheumatol., 2023; Lu et al, Nat. Rev. Rheumatol., 2019; Liang et al, Life Metab., 2024). Since 2000, Prof. Yin has co-authored around 170 peer-reviewed manuscripts in SCI-indexed journals including Science, Nature, Cell Metabolism, Nature Cancer, Nature Metabolism, Nature Review Cardiology, Nature Reviews Rheumatology, Molecular Cell, Journal of American Chemical Society, Hepatology, Redox Biology, Arthritis & Rheumatology, Free Radical Biology and Medicine, Journal of Biological Chemistry, Journal of Clinical Endocrinology and Metabolism, and Journal of American Society for Mass Spectrometry with > 14,700 Google Scholar citations and h-index of 66 (as of August 2024). Prof. Yin has been listed as the top 2% of the Most-Cited Scientists by Stanford University since 2021 and was awarded prestigious “Senior International Scientists” in 2021 by National Natural Science Fund of China.

Professor Yin received “Pollyanna Chu Yuet Wah Outstanding Mentor Award” of Chinese Academy of Sciences（中国科学院朱李月华优秀教师奖） in 2022; “Senior International Scientist” （外国资深研究学者）by NSF-China in 2021; “Outstanding Mentor Award” from ShanghaiTech University in 2020; CAS BR (2011) and “Shanghai Expert” (上海特聘专家“) by Shanghai Municipal Government in 2012; Travel Award from Society for Free Radical Biology and Medicine (SFRBM) in 2004 and Young Investigator Award in 2005; Best Research Paper from Vanderbilt School of Medicine 2006; Warren Fellowship from Department of Chemistry at Vanderbilt University in 2000.

Research Interests

Redox regulation of lipid and carbohydrate metabolism: lipid peroxidation, Reactive Oxygen Species (ROS), and ferroptosis
Metabolic homeostasis and tissue cross-talks
Metabolic reprogramming in tissue microenvironment
Immunometabolism in atherosclerosis and myocardial infarction
Nutrient sensing and metabolic pathways in metabolic diseases
Disease biomarker discovery using multi-omics integration, including metabolomics/lipidomomics, proteomics, transcriptomics, and single cell analysis , in combination with machine learning algorithms

Research Profiles

Recent External Competitive Grants (Since 2012)

GRF, “ALDOB Modulates Beta-Cell Insulin Secretion in Diabetes Through Insulin Receptor Pathways”, (2025-2027), 1,490,000 HKD, No. 9043653, PI.
GRF, TBRS, “Single-Cell Multi-Omics Study of Atherosclerotic Vascular Disease: Narrowing the Gap Between Bench and Bedside”, (2024-2028), 55,000,000 HKD, 8770011, Co-I
Shenzhen Medical Research Fund (SMARF), “Metabolic Basis of Immune Response in Hepatocellular Carcinoma” (2024-2026), 3,000,000 RMB, No. B2302042, PI.
Futian Research Project, “Single-Cell Metabolomics: Towards Applications in Cancer and Aging”, (2024-2025), 300,000 HKD, No. 9609327, PI
Natural Science Foundation of China (NSFC), Categorized Key Projects (2023-2025，中国自然科学基金委专项), ”Fructose uptake and metabolic homeostasis”, 2,500,000 RMB, No. 32241017, PI
Natural Science Foundation of China (NSFC), Research Fund for Senior International Scientists (2022-2023，中国自然科学基金委外国资深研究学者）, ”Physiological and pathophysiological basis for enzymatic plasticity”, 1,600,000 RMB, No. 32150710522, PI
Natural Science Foundation of China (NSFC), Key Research Project (2021-2025，中国自然科学基金委重点项目) , ”Mitochondrial ALDH2 in cholesterol metabolism”, 3,450,000 RMB, No. 32030053, PI
Ministry of Science and Technology of China (MOST), Key Research Project (2022-2025), ”Early detection, phenotyping and precision treatment of inflammatory arthritis”, 1,050,000 RMB, No. 2022YFC2503300, Co-I（Group Member）
Ministry of Science and Technology of China (MOST), Key Research Project (2019-2024), ”Detection and functional studies of novel metabolites during major organ development”, 860,000 RMB, No. 2022YFC2503300, Co-I
Shanghai Municipal Science and Technology Commission, Animal Model Project (2022-2025), ”Diabetic mouse model based on beta cell-specific ALDOB KO and R46A mutant”, 250,000 RMB, No. 22140903300, PI
Natural Science Foundation of China (NSFC), Major Research Program on Spatiotemporal Regulation of Metabolism (2019-2021), ”Spatiotemporal control of lipid metabolism by ALDH2 in Atherosclerosis”, 850,000 RMB, No. 91857112, PI
Ministry of Science and Technology of China (MOST), Key Research Project (2016-2020), ”Quality control and composition analysis during food processing”, 1,500,000 RMB, No. 2016YFD0400205, Co-I
Natural Science Foundation of China (NSFC), General Research Project (2017-2020) , ”Fructose-1,6-bisphosphate aldolase in metabolic reprogramming of hepatocellular carcinoma”, 610,000 RMB, No. 31671231, PI
Natural Science Foundation of China (NSFC), General Research Project (2015-2018) , ”Characterisation and functional study of a novel oxidized phospholipids in LDL in atherosclerosis”, 850,000 RMB, No. 31470831, PI
Ministry of Science and Technology of China (MOST), China Precision Medicine Initiative (2016-2018), ”Precision medicine approach to study gout using proteomics and metabolomics”, 1,000,000 RMB, No. 2016YFC0903403, Co-PI
Ministry of Science and Technology of China (MOST), Key Research Project (2012-2016), ”Biomarkers in non-alcoholic fatty liver disease”, 1,280,000 RMB, No. 2012CB524905, Co-I
Natural Science Foundation of China (NSFC), Major Research Program on Vascular homeostasis and remodelling (2015-2017), ”Tipping point and regulatory networks during the progression of atherosclerosis”, 750,000 RMB, No. 91439103, Co-PI
Natural Science Foundation of China (NSFC), General Research Project (2012-2015) , ”Mitochondrial cardiolipin oxidation in apoptosis”, 600,000 RMB, No. 31170809, PI

Academic Profiles

Secretary General, Asian Pacific Gout Consortium (APGC), (2018 - )
Managing Committee Member, HNE Club associated with the Society for Free Radical Research International (SFRRI) (2010–)
Vice president and Secretary General, Chinese Society for Redox Biology and Medicine, Biophysical Society of China, (2020–)
Deputy Secretary General and Council Member, Chinese Society for Metabolomics, Biophysical Society of China, (2019–)
Secretary General, Chinese Society for Hyperuricemia and Gout, China Society of Geriatrics, (2018–)
Council Member, Chinese Society for Metabolic Biology, Biophysical Society of China, (2019–)
Council member of Sub-committee of Atherosclerosis, Chinese Association of Pathophysiology (2016–)
Council member of China Society of Geriatrics (2018–)

Editorial Responsibilities

In addition to serving as an editor for Free Radical Biology and Medicine, Professor Yin is also on the editorial boards for six international journals in the field of redox biology, metabolism, and medicine. He also routinely reviews manuscripts for high impact journals in the field of metabolism, including Nature Metabolism, Cell Metabolism, Life Metabolism, Nature Communications, Nature Chemical Biology, among others.

Editor for Free Radical Biology and Medicine

Free Radical Biology and Medicine

Editorial Board member

Redox Biology

Redox Biochemistry and Chemistry

Redox Experimental Medicine

Global translational Medicine

Gout, Urate, and Crystal Deposition Disease

Journal of Integrative Agriculture

Position Availability

We are looking for motivated people to join our team as PhD students, postdoctoral fellows or research assistants. Please send your CV and a short summary of your previous research experience to Prof. YIN Huiyong at huiyoyin@cityu.edu.hk.

Selected Publication List (Since 2017)

(* corresponding author)

2024

Liang, Ningning^#, Yuan, Xuan^#, Zhang, Lili, Shen, Xia, Zhong, Shanshan, Li, Luxiao, Li, Rui, Xu, Xiaodong, Chen, Xin, Yin, Chunzhao, Guo, Shuyuan, Ge, Jing, Zhu, Mingjiang, Tao, Yongzhen, Chen, Shiting, Qian, Yongbing, Dalbeth, Nicola, Merriman, Tony R., Terkeltaub, Robert, Li, Changgui,* Xia, Qiang* and Yin, Huiyong*. Fatty acid oxidation-induced HIF-1α activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH. Life Metabolism 2024 3(5), DOI: 10.1093/lifemeta/loae01.

Shen X, Guo S, Liang N, Zhao M, Wang C, Li Z, Yan D, Zheng L, Yin H.* Biomarker discovery and metabolic profiling in serum of cardiovascular disease patients with untargeted metabolomics and machine learning. Clin Transl Med. 2024 Jun;14(6): e1722. doi: 10.1002/ctm2.1722.PMID: 38899752

Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P*. 7-Dehydrocholesterol dictates ferroptosis sensitivity. Nature. 2024 Feb; 626 (7998): 411-418. doi: 10.1038/s41586-023-06983-9. Epub 2024 Jan 31. PMID: 38297130

Pang, L.^#, Liang, N.^#, Li, C.^#, Merriman, T. R., Zhang, H., Yan, F., Sun, W., Li, R., Xue, X., Liu, Z., Wang, C., Cheng, X., Chen, S., Yin, H.*, Dalbeth, N.*, & Yuan, X.* (2024). A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. Mar; 1870(3):167009. doi: 10.1016/j.bbadis.2023.167009. Epub 2024 Jan 17. PMID: 38237409

2023

Yin C, Zhang C, Wang Y, Liu G, Wang N, Liang N, Zhang L, Tu Q, Lv J, Jiang H, Ma H, Du C, Li M, He X, Chen S, Guo J, Li S, Qin J, Li N*, Tao Y*, Yin H*. ALDOB/KAT2A interactions epigenetically modulate TGF-β expression and T cell functions in hepatocellular carcinogenesis. Hepatology. 2023 Dec 5. doi: 10.1097/HEP.0000000000000704. Online ahead of print. PMID: 38051951
Li Y^#, Tang S^#, Shi X^#, Lv J^#, Wu X, Zhang Y, Wang H, He J, Zhu Y, Ju Y, Zhang Y, Guo S, Yang W*, Yin H*, Chen L*, Gao D*, Jin G*. Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer. Cell Rep Med. 2023. Aug 10;101162. doi: 10.1016/j.xcrm.2023.101162. Online ahead of print
Wang M^#, Li R^#, Qi H, Pang L, Cui L, Liu Z, Lu J, Wang R, Hu S, Liang N, Tao Y, Dalbeth N, Merriman TR, Terkeltaub R, Yin H*, Li C*. Metabolomics and Machine Learning Identify Metabolic Differences and Potential Biomarkers for Frequent versus Infrequent Gout Flares. Arthritis Rheumatol. 2023 Jun 30. doi: 10.1002/art.42635. Online ahead of print.PMID: 37390372
Liu G, Liu Q, Wan N, Shen X, Cui H, Dong C, Zhang X, Yin H, Wang J, Funk CD, Yu Y. Cardioprotection by Peroxidase Activity of Prostaglandin H Synthases in Ischemia/Reperfusion Injury. Circulation. 2023 May 9;147(19):1467-1470. doi: 10.1161/CIRCULATIONAHA.122.061145. Epub 2023 May 8. PMID: 37155589
Li R, Liang N, Tao Y, Yin H*. Metabolomics in Hyperuricemia and Gout. Gout Urate Cryst. Depos. Dis. 2023, 1(1), 49- 61; https://doi.org/10.3390/gucdd1010006 - 21 Mar 2023
Cheng CK, Ding H, Jiang M, Yin H, Gollasch M, Huang Y. Perivascular adipose tissue: Fine-tuner of vascular redox status and inflammation. Redox Biol. 2023 Mar 20;62:102683. doi: 10.1016/j.redox.2023.102683. Online ahead of print.PMID: 36958248
Hao S, Zhang S, Ye J, Chen L, Wang Y, Pei S, Zhu Q, Xu J, Tao Y, Zhou N, Yin H, Duan CW, Mao C, Zheng M, Xiao Y. Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis. EMBO Rep. 2023 Mar 2:e56932. doi: 10.15252/embr. 202356932. Online ahead of print. PMID: 3686232
Zhang J, Guo Y, Zhao X, Pang J, Pan C, Wang J, Wei S, Yu X, Zhang C, Chen Y*, Yin H*, Xu F*. The role of aldehyde dehydrogenase 2 in cardiovascular disease. Nat Rev Cardiol. 2023 Feb 13. doi: 10.1038/s41569-023-00839-5. Online ahead of print. PMID: 36781974

2022

Zhao S, Tian Y, Wang S, Yang F, Xu J, Qin Z, Liu X, Cao M, Zhao P, Zhang G, Wang Z, Zhang Y, Wang Y, Lin K, Fang S, Wang Z, Han T, Tian M, Yin H, Tian J, Yu B. Prognostic value of gut microbiota-derived metabolites in patients with ST-segment elevation myocardial infarction. Am J Clin Nutr. 2022 Dec 28: S0002-9165(22)10614-3. doi: 10.1016/j.ajcnut.2022.12.013. Online ahead of print. PMID: 36811471
Shao F, Li R, Guo Q, Qin R, Su W, Yin H*, Tian L*. Plasma Metabolomics Reveals Systemic Metabolic Alterations of Subclinical and Clinical Hypothyroidism. J Clin Endocrinol Metab. 2022 Dec 17; 108(1):13-25. doi: 10.1210/clinem/dgac555.
Ding Y, Jiang Y, Zhu M, Zhu Q, He Y, Lu Y, Wang Y, Qi J, Feng Y, Huang R, Yin H, Li S and Sun Y. Follicular fluid lipidomic profiling reveals potential biomarkers of polycystic ovary syndrome: A pilot study. Front. Endocrinol. 2022, 13:960274. doi: 10.3389/fendo.2022.960274
Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ, Dick TP, Finkel T, Forman HJ, Janssen-Heininger Y, Gems D, Kagan VE, Kalyanaraman B, Larsson NG, Milne GL, Nyström T, Poulsen HE, Radi R, Van Remmen H, Schumacker PT, Thornalley PJ, Toyokuni S, Winterbourn CC, Yin H, Halliwell B. Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nat Metab. 2022 Jun; 4(6):651-662. doi: 10.1038/s42255-022-00591-z. Epub 2022 Jun 27. PMID: 35760871
Cao K, Liu Y, Liang N, Shen X, Li R, Yin H*, Xiang L*. Fatty Acid Profiling in Facial Sebum and Erythrocytes From Adult Patients With Moderate Acne. Front Physiol. 2022 Jun 21; 13:921866. doi: 10.3389/fphys.2022.921866. eCollection 2022.PMID: 35800343
Li L, Zhong S, Li R, Liang N, Zhang L, Xia S, Xu X, Chen X, Chen S, Tao Y, Yin H.* Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression. JCI Insight. 2022 Apr 8; 7(7): e155869. doi: 10.1172/jci.insight.155869.PMID: 35393951
Lu J, He Y, Terkeltaub R, Sun M, Ran Z, Xu X, Wang C, Li X, Hu S, Xue X, Yan F, Zhang H, Yin H, Shi Y, Dalbeth N, Li C. Colchicine prophylaxis is associated with fewer gout flares after COVID-19 vaccination. Ann Rheum Dis. 2022 Aug; 81(8):1189-1193. doi: 10.1136/annrheumdis-2022-222199. Epub 2022 Mar 11. PMID: 35277390
Sun L, Du H, Zong G, Guo Y, Chen Y, Chen Y, Yin H, Pei P, Yang L, Chu Q, Yu C, Li Y, Lv J, Zheng H, Zhou P, Chen J, Li L, Chen Z, Lin X; China Kadoorie Biobank Collaborative Group. Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals. Eur J Nutr. 2022 Sep; 61(6):3235-3246. doi: 10.1007/s00394-022-02879-y. Epub 2022 Apr 21. PMID: 35445833
Xiong Q, Sun L, Luo Y, Yun H, Shen X, Yin H, Chen X, Lin X. Different Isocaloric Meals and Adiposity Modify Energy Expenditure and Clinical and Metabolomic Biomarkers During Resting and Exercise States in a Randomized Crossover Acute Trial of Normal-Weight and Overweight/Obese Men. J Nutr. 2022 Apr 1; 152(4):1118-1129. doi: 10.1093/jn/nxac006.PMID: 35020917

2021

Liu G, Wang N, Zhang C, Li M, He X, Yin C, Tu Q, Shen X, Zhang L, Lv J, Wang Y, Jiang H, Chen S, Li N, Tao Y*, Yin H*. Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis. Hepatology. 2021 Dec; 74(6):3037-3055. doi: 10.1002/hep.32064. Epub 2021 Aug 26. PMID: 34292642
Huo S, Sun L, Zong G, Shen X, Zheng H, Jin Q, Li H, Yin H, Lin X. Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese. Nutrients. 2021 Apr 27; 13(5):1474. doi: 10.3390/nu13051474.PMID: 33925473
Pan Q^#, Zhong S^#, Wang H, Wang X, Li N, Li Y, Zhang G, Yuan H, Lian Y, Chen Q, Han Y, Guo J, Liu Q, Qiu T, Jiang J, Li Q, Tan M, Yin H, Peng J, Xiao Y, Qin J. The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability. Mol Cell. 2021 Jul 1; 81(13):2736-2751.e8. doi: 10.1016/j.molcel.2021.04.009. Epub 2021 Apr 30. PMID: 33932349
Li X, Liu T, Wu TT, Feng Y, Peng SJ, Yin H*, Wu YC*. SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease. Front Neurol. 2021 Apr 15; 12: 652882. doi: 10.3389/fneur.2021.652882. eCollection 2021.PMID: 33935952
Shen X^#, Wang C^#, Liang N, Liu Z, Li X, Zhu ZJ, Merriman TR, Dalbeth N, Terkeltaub R, Li C*, Yin H*. Serum Metabolomics Identifies Dysregulated Pathways and Potential Metabolic Biomarkers for Hyperuricemia and Gout. Arthritis Rheumatol. 2021 Sep; 73(9):1738-1748. doi: 10.1002/art.41733. Epub 2021 Aug 6. PMID: 33760368 (^# Equal contribution)
Zhong S^#, Li L^#, Liang N, Zhang L, Xu X, Chen S, Yin H*. Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver. Redox Biol. 2021 May; 41:101919. doi: 10.1016/j.redox.2021.101919. Epub 2021 Mar 10. PMID: 33740503 (^# Equal contribution)
Chen X, Li X, Xu X, Li L, Liang N, Zhang L, Lv J, Wu YC, Yin H*. Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation. Free Radic Res. 2021 Apr; 55(4):405-415. doi: 10.1080/10715762.2021.1876856. Epub 2021 Jan 27. PMID: 33455488
Jiang Y^#, Tao Y^#, Zhang X^#, Wei X, Li M, He X, Zhou B, Guo W, Yin H*, Cheng S.* Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma. Mol Oncol. 2021 Feb; 15(2):710-724. doi: 10.1002/1878-0261.12846. Epub 2020 Nov 22. PMID: 33155364

2020

He X^#, Li M^#, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y*, Cheng S*, Yin H.* Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex. PLoS Biol. 2020 Dec 4; 18(12): e3000803. doi: 10.1371/journal.pbio.3000803. eCollection 2020 Dec. PMID: 33275593
Zhang M, Gao J, Zhao X, Zhao M, Ma D, Zhang X, Tian D, Pan B, Yan X, Wu J, Meng X, Yin H, Zheng L. p38α in macrophages aggravates arterial endothelium injury by releasing IL-6 through phosphorylating megakaryocytic leukemia 1. Redox Biol. 2021 Jan; 38:101775. doi: 10.1016/j.redox.2020.101775. Epub 2020 Nov 1. PMID: 33171330
Li Q, Liu G, Wang N, Yin H and Li Z. Synthesis and anticancer activity of benzotriazole derivatives. Journal of Heterocyclic Chemistry. 2020; 57:1220-1227.
Lu J, He Y, Cui L, Xing X, Liu Z, Li X, Zhang H, Li H, Sun W, Ji A, Wang Y, Yin H, Li C. Hyperuricemia Predisposes to the Onset of Diabetes via Promoting Pancreatic β-Cell Death in Uricase-Deficient Male Mice. Diabetes. 2020 Jun; 69(6): 1149-1163. doi: 10.2337/db19-0704. Epub 2020 Apr 20. PMID: 32312870
Liu G^#, Shi A^#, Wang N, Li M, He X, Yin C, Tu Q, Shen X, Tao Y*, Wang Q*, Yin H. *Polyphenolic Proanthocyanidin-B2 suppresses proliferation of liver cancer cells and hepatocellular carcinogenesis through directly binding and inhibiting AKT activity. Redox Biol. 2020 Oct; 37:101701. doi: 10.1016/j.redox.2020.101701. Epub 2020 Aug 25. PMID: 32863234
Li M^#, He X^#, Guo W^#, Yu H, Zhang S, Wang N, Liu G, Sa R, Shen X, Jiang Y, Tang Y, Zhuo Y, Yin C, Tu Q, Li N, Nie X, Li Y, Hu Z, Zhu H, Ding J, Li Z, Liu T, Zhang F, Zhou H, Li S, Yue J, Yan Z, Cheng S*, Tao Y*, Yin H.* Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways. Nat Cancer. 2020 Jul; 1(7):735-747. doi: 10.1038/s43018-020-0086-7. Epub 2020 Jul 6. PMID: 35122041
Wang N^#, Liu H^#, Liu G, Li M, He X, Yin C, Tu Q, Shen X, Bai W, Wang Q*, Tao Y*, Yin H.* Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis. Redox Biol. 2020 May; 32:101495. doi: 10.1016/j.redox.2020.101495. Epub 2020 Mar 7. PMID: 32171725
Xu L, Hu C, Liu Y, Li S, Vetter W, Yin H*, Wang Y*. Development of a sensitive and quantitative method for the identification of two major furan fatty acids in human plasma. J Lipid Res. 2020 Apr; 61(4):560-569. doi: 10.1194/jlr.D119000514. Epub 2020 Feb 6. PMID: 32029512
Jiang Y, Qi J, Xue X, Huang R, Zheng J, Liu W, Yin H, Li S. Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics. Gynecol Endocrinol. 2020 Jun; 36 (6): 508-512. doi: 10.1080/09513590.2019.1698026. Epub 2019 Dec 3. PMID: 3179336
Li S, Qi J, Tao Y, Zhu Q, Huang R, Liao Y, Yue J, Liu W, Zhao H, Yin H*, Sun Y*. Elevated levels of arachidonic acid metabolites in follicular fluid of PCOS patients. Reproduction. 2020 Feb; 159(2):159-169. doi: 10.1530/REP-19-0136. PMID: 3177010

2019

Shi L, Chen X, Zang A, Li T, Hu Y, Ma S, Lü M, Yin H, Wang H, Zhang X, Zhang B, Leng Q, Yang J, Xiao H. TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. PLoS Biol. 2019 Aug 21; 17(8):e3000420. doi: 10.1371/journal.pbio.3000420. eCollection 2019 Aug. PMID: 31433805
Lu J, Dalbeth N, Yin H, Li C, Merriman TR, Wei WH. Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul; 15(7): 413-426. doi: 10.1038/s41584-019-0222-x.PMID: 31118497
Ceddia RP, Downey JD, Morrison RD, Kraemer MP, Davis SE, Wu J, Lindsley CW, Yin H, Daniels JS, Breyer RM. The effect of the EP3 antagonist DG-041 on male mice with diet-induced obesity. Prostaglandins Other Lipid Mediat. 2019 Oct; 144:106353. doi: 10.1016/j.prostaglandins.2019.106353. Epub 2019 Jul 2. PMID: 31276827
Feng Z, Wei Y, Zhang Y, Qiu Y, Liu X, Su L, Liang N, Yin H, Ding Q. Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression. Theranostics. 2019 May 26; 9(12): 3501-3514. doi: 10.7150/thno.31951. eCollection 2019.PMID: 31281493
Xue JH, Chen GD, Hao F, Chen H, Fang Z, Chen FF, Pang B, Yang QL, Wei X, Fan QQ, Xin C, Zhao J, Deng X, Wang BA, Zhang XJ, Chu Y, Tang H, Yin H, Ma W, Chen L, Ding J, Weinhold E, Kohli RM, Liu W, Zhu ZJ, Huang K, Tang H, Xu GL. A vitamin-C-derived DNA modification catalysed by an algal TET homologue. Nature. 2019 May; 569(7757): 581-585. doi: 10.1038/s41586-019-1160-0. Epub 2019 May 1. PMID: 31043749
Zhong S, Li L, Shen X, Li Q, Xu W, Wang X, Tao Y, Yin H.* An update on lipid oxidation and inflammation in cardiovascular diseases. Free Radic Biol Med. 2019 Nov 20; 144:266-278. doi: 10.1016/j.freeradbiomed.2019.03.036. Epub 2019 Apr 1. PMID: 30946962
Li L, Zhong S, Shen X, Li Q, Xu W, Tao Y, Yin H.* Recent development on liquid chromatography-mass spectrometry analysis of oxidized lipids. Free Radic Biol Med. 2019 Nov 20; 144:16-34. doi: 10.1016/j.freeradbiomed.2019.06.006. Epub 2019 Jun 13. PMID: 31202785
Chao H, Lin C, Zuo Q, Liu Y, Xiao M, Xu X, Li Z, Bao Z, Chen H, You Y, Kochanek PM, Yin H, Liu N, Kagan VE, Bayır H, Ji J. Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury. J Neurosci. 2019 Mar 6; 39(10):1930-1943. doi: 10.1523/JNEUROSCI.3415-17.2018. Epub 2019 Jan 9. PMID: 30626699
Guo S, Lu J, Zhuo Y, Xiao M, Xue X, Zhong S, Shen X, Yin C, Li L, Chen Q, Zhu M, Chen B, Zhao M, Zheng L, Tao Y, Yin H.* Endogenous cholesterol ester hydroperoxides modulate cholesterol levels and inhibit cholesterol uptake in hepatocytes and macrophages. Redox Biol. 2019 Feb; 21:101069. doi: 10.1016/j.redox.2018.101069. Epub 2018 Dec 12. PMID: 30576926
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H.* Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. J Clin Invest. 2019 Jan 2; 129(1):252-267. doi: 10.1172/JCI122064. Epub 2018 Dec 3. PMID: 30375985

2018

Zhang YY, Fu ZY, Wei J, Qi W, Baituola G, Luo J, Meng YJ, Guo SY, Yin H, Jiang SY, Li YF, Miao HH, Liu Y, Wang Y, Li BL, Ma YT, Song BL. A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. Science. 2018 Jun 8; 360(6393):1087-1092. doi: 10.1126/science.aao6575. PMID: 29880681
Liu G, Gong Y, Zhang R, Piao L, Li X, Liu Q, Yan S, Shen Y, Guo S, Zhu M, Yin H, Funk CD, Zhang J, Yu Y. Resolvin E1 attenuates injury-induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration. FASEB J. 2018 Oct; 32(10):5413-5425. doi: 10.1096/fj.201800173R. Epub 2018 May 3.PMID: 29723062
Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H*, Wu YC*. Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function. Front Aging Neurosci. 2018 Apr 27; 10: 121. doi: 10.3389/fnagi.2018.00121. eCollection 2018.PMID: 29755339
Guo S, Li L, Yin H. Cholesterol Homeostasis and Liver X Receptor (LXR) in Atherosclerosis. Cardiovasc Hematol Disord Drug Targets. 2018; 18(1):27-33. doi: 10.2174/1871529X18666180302113713.PMID: 29512473
Huang, R.; Xue, X.; Li, S.; Wang, Y.; Sun, Y.; Liu, W.; Yin, H.*; Tao, T.*, Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats. Journal of cellular and molecular medicine 2018; 22: 3388-3396.
Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun. 2018 Jan 2; 9(1):11. doi: 10.1038/s41467-017-02401-7.PMID: 29296021
He D, Zhao M, Wu C, Zhang W, Niu C, Yu B, Jin J, Ji L, Willard B, Mathew AV, Chen YE, Pennathur S, Yin H, He Y, Pan B, Zheng L. Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1. Redox Biol. 2018 May; 15:228-242. doi: 10.1016/j.redox.2017.11.027. Epub 2017 Dec 8. PMID: 29277016
Chen Q, Wang N, Zhu M, Lu J, Zhong H, Xue X, Guo S, Li M, Wei X, Tao Y, Yin H.* TiO2 nanoparticles cause mitochondrial dysfunction, activate inflammatory responses, and attenuate phagocytosis in macrophages: A proteomic and metabolomic insight. Redox Biol. 2018 May; 15:266-276. doi: 10.1016/j.redox.2017.12.011. Epub 2017 Dec 28. PMID: 2929443

2017

Xu L, Sinclair AJ, Faiza M, Li D, Han X, Yin H, Wang Y. Furan fatty acids - Beneficial or harmful to health? Prog Lipid Res. 2017 Oct; 68:119-137. doi: 10.1016/j.plipres.2017. 10.002. Epub 2017 Oct 16. PMID: 29051014
Cui Y, Shu XO, Li HL, Yang G, Wen W, Gao YT, Cai Q, Rothman N, Yin H, Lan Q, Xiang YB, Zheng W. Prospective study of urinary prostaglandin E2 metabolite and pancreatic cancer risk. Int J Cancer. 2017 Dec 15; 141(12):2423-2429. doi: 10.1002/ijc.31007. Epub 2017 Aug 29. PMID: 28815606
Liu G, Liu Q, Shen Y, Kong D, Gong Y, Tao B, Chen G, Guo S, Li J, Zuo S, Yu Y, Yin H, Zhang L, Zhou B, Funk CD, Zhang J, Yu Y. Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice. Br J Pharmacol. 2018 Apr; 175(8):1205-1216. doi: 10.1111/bph.14041. Epub 2017 Oct 22. PMID: 28925017
Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG, Lin SC. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 2017 Aug 3; 548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19. PMID: 28723898
Wang YJ, Bian Y, Luo J, Lu M, Xiong Y, Guo SY, Yin HY, Lin X, Li Q, Chang CCY, Chang TY, Li BL, Song BL. Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation. Nat Cell Biol. 2017 Jul; 19(7):808-819. doi: 10.1038/ncb3551. Epub 2017 Jun 12. PMID: 28604676
Xiao M, Zhong H, Xia L, Tao Y, Yin H.* Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria. Free Radic Biol Med. 2017 Oct; 111:316-327. doi: 10.1016/j.freeradbiomed. 2017.04.363. Epub 2017 Apr 27. PMID: 28456642
Lu J, Chen B, Chen T, Guo S, Xue X, Chen Q, Zhao M, Xia L, Zhu Z, Zheng L, Yin H.* Comprehensive metabolomics identified lipid peroxidation as a prominent feature in human plasma of patients with coronary heart diseases. Redox Biol. 2017 Aug; 12:899-907. doi: 10.1016/j.redox.2017.04.032. Epub 2017 Apr 26. PMID: 28472752
Sun XN, Li C, Liu Y, Du LJ, Zeng MR, Zheng XJ, Zhang WC, Liu Y, Zhu M, Kong D, Zhou L, Lu L, Shen ZX, Yi Y, Du L, Qin M, Liu X, Hua Z, Sun S, Yin H, Zhou B, Yu Y, Zhang Z, Duan SZ. T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma. Circ Res. 2017 May 12; 120(10):1584-1597. doi: 10.1161/CIRCRESAHA.116. 310480. Epub 2017 Mar 15. PMID: 28298295
Zhang YY, Li C, Yao GF, Du LJ, Liu Y, Zheng XJ, Yan S, Sun JY, Liu Y, Liu MZ, Zhang X, Wei G, Tong W, Chen X, Wu Y, Sun S, Liu S, Ding Q, Yu Y, Yin H, Duan SZ. Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ERα/HGF/Met Pathway. Diabetes. 2017 Jun; 66(6):1535-1547. doi: 10.2337/db16-1354. Epub 2017 Mar 21. PMID: 28325853
Li J, Kong D, Wang Q, Wu W, Tang Y, Bai T, Guo L, Wei L, Zhang Q, Yu Y, Qian Y, Zuo S, Liu G, Liu Q, Wu S, Zang Y, Zhu Q, Jia D, Wang Y, Yao W, Ji Y, Yin H, Nakamura M, Lazarus M, Breyer RM, Wang L, Yu Y. Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation. EMBO Mol Med. 2017 May; 9(5):571-588. doi: 10.15252/emmm.201606987.PMID: 2834170
Lu J, Guo S, Xue X, Chen Q, Ge J, Zhuo Y, Zhong H, Chen B, Zhao M, Han W, Suzuki T, Zhu M, Xia L, Schneider C, Blackwell TS, Porter NA, Zheng L, Tsimikas S, Yin H.* Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis. J Biol Chem. 2017 Mar 31; 292(13):5378-5391. doi: 10.1074/jbc.M116.751909. Epub 2017 Feb 15. PMID: 28202546
Zhong H, Xiao M, Zarkovic K, Zhu M, Sa R, Lu J, Tao Y, Chen Q, Xia L, Cheng S, Waeg G, Zarkovic N, Yin H.* Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer. Free Radic Biol Med. 2017 Jan; 102:67-76. doi: 10.1016/j.freeradbiomed. 2016.10.494. Epub 2016 Nov 9. PMID: 27838437
Yao P, Sun L, Lu L, Ding H, Chen X, Tang L, Xu X, Liu G, Hu Y, Ma Y, Wang F, Jin Q, Zheng H, Yin H, Zeng R, Chen Y, Hu FB, Li H, Lin X. Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation. J Clin Endocrinol Metab. 2017 Jan 1; 102(1): 100-110. doi: 10.1210/jc.2016-2930.PMID: 2776885
Li S, Chu Q, Ma J, Sun Y, Tao T, Huang R, Liao Y, Yue J, Zheng J, Wang L, Xue X, Zhu M, Kang X, Yin H*, Liu W*. Discovery of Novel Lipid Profiles in PCOS: Do Insulin and Androgen Oppositely Regulate Bioactive Lipid Production? J Clin Endocrinol Metab. 2017 Mar 1; 102(3):810-821. doi: 10.1210/jc.2016-2692. PMID: 27886515
Hu H, Zhu W, Qin J, Chen M, Gong L, Li L, Liu X, Tao Y, Yin H, Zhou H, Zhou L, Ye D, Ye Q, Gao D. Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis. Hepatology. 2017 Feb; 65(2):515-528. doi: 10.1002/hep.28887. Epub 2016 Nov 29. PMID: 27774669

28 August 2024

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YIN, Huiyong (尹慧勇)