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Compared with the existing laborious, resource-intensive and disruptive methods for monitoring the wound healing status, Dr XU Chenjie and his collaborators have developed mRNA nanosensors (i.e. NanoFlare) that can reveal the healing status through targeted and semi-quantitative examination of the mRNA biomarkers in skin cells. The optical sensors can diffuse through skin layers, target and quantify cellular mRNA biomarkers, and report the information more accurately and non-invasively.

The research has been published in Advanced Science under the title “Monitoring Wound Healing with Topically Applied Optical NanoFlare mRNA Nanosensors”.

Press coverage:
(13 JUL 2022) 跨國研究團隊開發出mRNA納米感測器，可監測傷口癒合狀態 [sohu]