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Leanne Lai-Hang Chan (陳儷行)

BEng(HKU), MSc(USC), PhD(USC)

Associate Professor

Contact Information

Office: G6356 AC1
Phone: 3442 9120
Fax: 3442 0562
Email: leanne.chan@cityu.edu.hk
Web: Personal Homepage

Research Interests

  • Neural device interface
  • In vivo electrophysiology
  • Retinal electrical stimulation
  • Retinal prostheses
  • Computer vision
Dr. Leanne Chan is Associate Professor of Electrical Engineering. She earned her undergraduate degree in electrical and electronic engineering at the University of Hong Kong. She obtained her MS and PhD degrees in electrical engineering and biomedical engineering respectively from University of Southern California, Los Angeles, United States. Following a couple of years of postdoctoral work at the Developmental Neuroscience Program of the Saban Research Institute, Children’s Hospital of Los Angeles, she joined the faculty of the City University of Hong Kong in December 2011. Dr. Chan is a senior member of the IEEE Society. She is a member of the Society of Neuroscience and the Engineering in Medicine and Biology Society (EMBS).

Research Summary

Applying electrical pulses to surviving cells in the neural retina has proven to be a potential treatment for people who suffer from outer retinal diseases (one form of blindness), in which this approach is becoming a viable clinical option. Understanding the neural response to electrical stimulation and the mechanisms that link electrical stimulation to the neuromodulation in the visual and non-visual brain circuitries form the primary focus of Dr. Chan’s research interests. Retinal implant devices consist of three major components: wireless telemetry system, stimulating microelectrode array, and device-tissue interface – over a prolonged stimulation, neuromodulation to the brain circuitry will also be affected. Dr. Chan’s group employs a combination of neural engineering and electrophysiological approaches to analyze and interpret physiological data obtained from invasive and noninvasive studies in rodents in the Neural Interface Research (NIR) Laboratory. The NIR laboratory collaborates closely with electronic engineers, material scientists, molecular and behavioral neuroscientists from various disciplines including local and overseas universities. Previous collaborated research studies have developed a novel coil structure to enhance the efficiency of power transfer under coils misalignment using a combination of numerical analysis and computational modeling (in collaboration with Prof. Henry Chung from the CityU Electronic Engineering Department). Recent research studies have focused on the issues of cortical alterations induced by retinal degeneration in visually impaired rodents using electrophysiological approach. The NIR laboratory is also working on the development of an optogenetics and imaging approach to enhance the stimulation and neural recording techniques.


Publications Show All Publications Show Prominent Publications


Journal

  • Malik, A. , Eldaly, A.B.M. , Chen, K. & Chan, L.L.H. (Jun 2022). Neuronal Oscillatory Signatures in the Developing Mouse Visual Cortex After Short-Term Monocular Deprivation. Cerebral Cortex. 32(12). 2657 - 2667. doi:10.1093/cercor/bhab372
  • Yu, W.S. , Aquili, L. , Wong, K.H. , Lo, A.C.Y. , Chan, L.L.H. , Chan, Y.S. & Lim, L.W. (Jun 2022). Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models. Annals of the New York Academy of Sciences. doi:10.1111/nyas.14850
  • Yu, W.S. , Tse, A.C.K. , Guan, L. , Chiu, J.LY. , Tan, S.Z.K. , Khairuddin, S.S. , Agadagba, S.K. , Lo, A.C.Y. , CHan, Y.S. , Chan, L.L.H. & Lim, L.W. (May 2022). Antidepressant-like effects of transcorneal electrical stimulation in rat models. Brain Stimulation. 15(3). 843 - 856. doi:10.1016/j.brs.2022.05.018
  • Agadagba, S.K. , Eldaly, A.B.M. & Chan, L.L.H. (Feb 2022). Transcorneal Electrical Stimulation Induces Long-Lasting Enhancement of Brain Functional and Directional Connectivity in Retinal Degeneration Mice. Frontiers in Cellular Neuroscience. 16. 785199 doi:10.3389/fncel.2022.785199
  • Chowdhury, M.H. , Eldaly, A.B.M. , Agadagba, S.K. , Cheung, R.C.C. & Chan, L.L.H. (Jan 2022). Machine Learning Based Hardware Architecture for DOA Measurement From Mice EEG. IEEE Transactions on Biomedical Engineering. 69(1). 314 - 324. doi:10.1109/TBME.2021.3093037
  • Yu, W.S. , Kwon, S.H. , Agadagba, S.K. , Chan, L.L.H. , Wong, K.H. & Lim, L.W. (Sep 2021). Neuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression. Cells. 10(9). 2492 doi:10.3390/cells10092492
  • Xie, H. , Wang, Y. , YE, Z. , Fang, S. , Xu, Z. , Wu, T. & Chan, L.L.H. (Jun 2021). Monitoring Cortical Response and Electrode-Retina Impedance Under Epiretinal Stimulation in Rats. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 29. 1178 - 1187. doi:10.1109/TNSRE.2021.3090904
  • Chen, K. , Hou, B. , Zhao, Y. , Yuan, P. , Yao, D. & Chan, L.L.H. (Dec 2020). Residual contrast response in primary visual cortex of rats with inherited retinal degeneration. Vision Research. 177. 6 - 11. doi:10.1016/j.visres.2020.08.007
  • Agadagba, S. , Li, X. & Chan, L.L.H. (Oct 2020). Excitation of the Pre-frontal and Primary Visual Cortex in Response to Transcorneal Electrical Stimulation in Retinal Degeneration Mice. Frontiers in Neuroscience. 14. 572299 doi:10.3389/fnins.2020.572299
  • Chen, K. , Zhao, Y. , Liu, T. , Su, Z. , Yu, H. , Chan, L.L.H. , Liu, T. & Yao, D. (Aug 2020). Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex. Journal of Visualized Experiments. 156. e60600 doi:10.3791/60600
  • Gai, H. , Wang, Y. , Chan, L.L.H. & Chiu, B.C.Y. (Jul 2020). Identification of Retinal Ganglion Cells from β-III Stained Fluorescent Microscopic Images. Journal of Digital Imaging. 33. 1352 - 1363. doi:10.1007/s10278-020-00365-7
  • Tam, D.Y. , Ho, J.W.T. , Chan, M.S. , Lau, C.H. , Chang, T.J.H. , Leung, H.M. , Liu, L.S. , Wang, F. , Chan, L.L.H. , Tin, C. & Lo, P.K. (May 2020). Penetrating the Blood–Brain Barrier by Self-Assembled 3D DNA Nanocages as Drug Delivery Vehicles for Brain Cancer Therapy. ACS Applied Materials & Interfaces. 12(26). 28929 - 28940. doi:10.1021/acsami.0c02957
  • Chow, J.P.-W. , Chung, H.S.-H. , Chan, L.L.H. , Shen, R. & Tang, S.C. (Oct 2019). Optimal Design and Experimental Assessment of a Wireless Power Transfer System for Home-Cage Monitoring. IEEE Transactions on Power Electronics. 34(10). 9779 - 9793. doi:10.1109/TPEL.2019.2894182
  • Cui, H. , Xie, X. , Xu, S. , Chan, L.L.H. & Hu, Y. (Aug 2019). Electrochemical characteristics of microelectrode designed for electrical stimulation. BioMedical Engineering OnLine. 18. 86 doi:10.1186/s12938-019-0704-8
  • Yu, C. , Luo, L. , Chan, L.L.H. , Rakthanmanon, T. & Nutanong, S. (Feb 2019). A fast LSH-based similarity search method for multivariate time series. Information Sciences. 476. 337 - 356. doi:10.1016/j.ins.2018.10.026
  • Kuang, H. , Chen, L. , Chan, L.L.H. , Cheung, R.C.C. & Yan, H. (Jan 2019). Feature Selection Based on Tensor Decomposition and Object Proposal for Night-Time Multiclass Vehicle Detection. IEEE Transactions on Systems, Man, and Cybernetics: Systems. 49(1). 71 - 80. doi:10.1109/TSMC.2018.2872891
  • Duan, Y. , Kuang, H. , Qiu, W. , Chan, L.L.H. & Yan, H. (Jun 2018). Cascade feature selection and coarse-to-fine mechanism for nighttime multiclass vehicle detection. Journal of Electronic Imaging. 27(3). 033042 doi:10.1117/1.JEI.27.3.033042
  • Wang, Y. , Chen, K. & Chan, L.L.H. (May 2018). Responsive neural activities in the primary visual cortex of retina-degenerated rats. Neuroscience. 383. 94 - 97. doi:10.1016/j.neuroscience.2018.05.006
  • Jiang, Q. , Li, G. , Zhao, H. , Shengq, W. , Yue, L. , Su, M. , Weng, S. , Chan, L.L.H. , Zhou, Q. , Humayun, M. , Qiu, W. & Zheng, H. (May 2018). Temporal neuromodulation of retinal ganglion cells by low-frequency focused ultrasound stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 26(5). 969 - 976. doi:10.1109/TNSRE.2018.2821194
  • Kuang, H. , Yang, K.-F. , Chen, L. , Li, Y. , Chan, L.L.H. & Yan, H. (Mar 2018). Bayes Saliency Based Object Proposal Generator for Nighttime Traffic Images. IEEE Transactions on Intelligent Transportation Systems. 19(3). 814 - 825. doi:10.1109/TITS.2017.2702665
  • Kuang, H. , Liu, C. , Chan, L.L.H. & Yan, H. (Mar 2018). Multi-class fruit detection based on image region selection and improved object proposals. Neurocomputing. 283. 241 - 255. doi:10.1016/j.neucom.2017.12.057
  • Vinzons, L.U. , Shu, L. , Yip, S. , Wong, C.-Y. , Chan, L.L.H. & Ho, J.C. (Dec 2017). Unraveling the morphological evolution and etching kinetics of porous silicon nanowires during metal-assisted chemical etching. Nanoscale Research Letters. 12(1). 385 doi:10.1186/s11671-017-2156-z
  • Kumar, G. , Au, N.P.B. , Lei, N. Y. , Mak, Y. L. , Chan, L.L.H. , Lam, H.W.M. , Chan, L. L. , Lam, K.S.P. & Ma, C.H.E. (Sep 2017). Acute exposure to Pacific ciguatoxin reduces electroencephalogram activity and disrupts neurotransmitter metabolic pathways in motor cortex. Molecular Neurobiology. 54(7). 5590 - 5603. doi:10.1007/s12035-016-0093-y
  • Wang, J. , Xie, H. , Chung, T. , Chan, L.L.H. & Pang, S. W. (Sep 2017). Neural Probes with Integrated Temperature Sensors for Monitoring Retina and Brain Implantation and Stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 25(9). 1663 - 1673. doi:10.1109/TNSRE.2016.2634584
  • Gao, M. , Yu, Y. , Zhao, H. , Li, G. , Jiang, H. , Wang, C. , Cai, F. , Chan, L.L.H. , Chiu, B. , Qian, W. , Qiu, W. & Zheng, H. (Sep 2017). Simulation study of an ultrasound retinal prosthesis with a novel contact-lens array for noninvasive retinal stimulation. Transactions on Neural Systems & Rehabilitation Engineering. 25(9). 1605 - 1611. doi:10.1109/TNSRE.2017.2682923
  • Huang, X.-T. , Yuan, Z. , Chan, L.L.H. , Zhao, Z. & Yan, H. (May 2017). Inference of cellular level signaling networks using single-cell gene expression data in C. elegans reveals mechanisms of cell fate specification. Bioinformatics. 33(10). 1528 - 1535. doi:10.1093/bioinformatics/btw796
  • Kuang, H. , Zhang, X. , Liu, Y.-J. , Chan, L.L.H. & Yan, H. (Apr 2017). Nighttime vehicle detection based on bio-inspired image enhancement and weighted score-level feature fusion. IEEE Transactions on Intelligent Transportation Systems. 18(4). 927 - 936. doi:10.1109/TITS.2016.2598192
  • Kuang, H. , Chen, L. , Gu, F. , Chen, J. , Chan, L.L.H. & Yan, H. (May 2016). Combining region of interest extraction and image enhancement for nighttime vehicle detection. IEEE Intelligent Systems. 31(3). 57 - 65 doi:10.1109/MIS.2016.17
  • Chen, K. , Wang, Y. , Liang, X. , Zhang, Y. , Ng, T.K. & Chan, L.L.H. (May 2016). Electrophysiology Alterations in Primary Visual Cortex Neurons of Retinal Degeneration (S334ter-line-3) Rats. Scientific Reports. 6. 26793 doi:10.1038/srep26793
  • Wang, Y. , Chen, K. , Xu, P. , Ng, T.K. & Chan, L.L.H. (Apr 2016). Spontaneous neural activity in the primary visual cortex of retinal degenerated rats. Neuroscience Letters. 623. 42 - 46. doi:10.1016/j.neulet.2016.04.062
  • Kuang, H. , Chan, L.L.H. , Liu, C. & Yan, H. (Jan 2016). Fruit classification based on weighted score level feature fusion. Journal of Electronic Imaging. 25(1). doi:10.1117/1.JEI.25.1.013009
  • Huang, X.T. , Zhu, Y. , Chan, L.L.H. , Zhao, Z. & Yan, H. (Nov 2015). An integrative C. elegans protein–protein interaction network with reliability assessment based on a probabilistic graphical model. Molecular BioSystems. 12(1). 85 - 92. doi:10.1039/C5MB00417A
  • Chow, J.P. , Chen, N. , Chung, H.S. & Chan, L.L.H. (Nov 2015). An investigation into the use of orthogonal winding in loosely-coupled link for improving power transfer efficiency under coil misalignment. IEEE Transactions on Power Electronics. 30(10). 5632 - 5649. doi:10.1109/TPEL.2014.2374651
  • Ho, V.W. , Wong, M.K. , An, X. , Guan, D. , Shao, J. , Ng, H.C. , Ren, X. , He, K. , Liao, J. , Ang, Y. , Chen, L. , Huang, X. , Yan, B. , Xia, Y. , Chan, L.L.H. , Chow, K.L. , Yan, H. & Zhao, Z. (Oct 2015). Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry. Molecular Systems Biology. 11(6). 814 doi:10.15252/msb.20145857
  • Sui, X. , Huang, Yu. , Feng, F. , Huang, C. , Chan, L.L.H. & Wang, G. (May 2015). 3D Finite Element Modeling of Epi-retinal Stimulation — Impact of Prosthetic Electrode Size and Distance from the Retina. The International Journal of Artificial Organs. 38(5). 277 - 287. doi:10.5301/ijao.5000412
  • Khalifa, A. , Gao, Z. , Bermak, A. , Bermak, A. & Chan, L.L.H. (May 2015). A Novel Method for the Fabrication of a High-Density Carbon Nanotube Microelectrode Array. Sensing and BioSensing Research. 5. 1 - 7. doi:10.1016/j.sbsr.2015.04.001
  • Stephany, C.-E. , Chan, L.L.H. , Parivash, S.N. , Dorton, H.M. , Piechowicz, M. , Qiu, S. & McGee, A.W. (Aug 2014). Plasticity of binocularity and visual acuity are differentially limited by nogo receptor. Journal of Neuroscience. 34(35). 11631 - 11640. doi:10.1523/JNEUROSCI.0545-14.2014
  • Huang, X. , Chen, L. , Chim, H. , Chan, L.L.H. , Zhao, Z. & Yan, H. (Dec 2013). Boolean genetic network model for the control of C. elegans early embryonic cell cycles. Biomedical Engineering Online. 12 (Suppl 1). S1 doi:10.1186/1475-925X-12-S1-S1
  • Chen, L. , Chan, L.L.H. , Zhao, Z. & Yan, H. (Nov 2013). A novel cell nuclei segmentation method for 3D C. elegans embryonic time-lapse images. BMC Bioinformatics. 14(1). 328 doi:10.1186/1471-2105-14-328
  • Ray, A. , Chan, L.L.H. , Gonzalez, A. , Humayun, M.S. & Weiland, J.D. (Dec 2011). Impedance as a method to sense proximity at the electrode-retina interface. IEEE Transactions on Neural System and Rehabilitation Engineering. 19(6). 696 - 699. doi:10.1109/TNSRE.2011.2169428
  • Chan, L.L.H. , Lee, E-J. , Humayun, M.S. & Weiland, J.D. (Jun 2011). Both electrical stimulation thresholds and SMI-32-immunoreactive retinal ganglion cell density correlate with age in S334ter line 3 rat retina. Journal of Neurophysiology. 105(6). 2687 - 2697. doi:10.1152/jn.00619.2010
  • Ray, A. , Sun, G.J. , Chan, L. , Grzywacz, N.M. , Weiland, J.D. & Lee, E-J. (Feb 2010). Morphological alterations in retinal neurons in the S334ter-line3 transgenic rat. Cell and Tissue Research. 339(3). 481 - 491. doi:10.1007/s00441-009-0916-5

Conference Paper

  • Agadagba, S.K. , Eldaly, A.B.M. & Chan, L.L.H. (Nov 2021). ECoG power alterations across stages of prolonged transcorneal electrical stimulation in the blind mice. 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). (pp. 5784 - 5787). Mexico: IEEE. doi:10.1109/EMBC46164.2021.9629894
  • Malik, A. , Eldaly, A.B.M. & Chan, L.L.H. (Nov 2021). Phase-amplitude modulation during critical period plasticity in mouse visual cortex. 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). (pp. 96 - 99). Mexico: IEEE. doi:10.1109/EMBC46164.2021.9629593
  • Hou, B. , Chen, K. , Zhao, Y. & Chan, L.L.H. (Sep 2020). Variation in Spontaneous Activity and Visual Evoked Response in Primary Visual Cortex of the S334ter-3 Rats. International Conference on Energy, Environment and Bioengineering. 185. (pp. 03034 E3S Web of Conferences. doi:10.1051/e3sconf/202018503034
  • Agadagba, S.K. , Eldaly, A.B.M. & Chan, L.L.H. (Jul 2020). Spontaneous Feedforward Connectivity in Electrically Stimulated Retinal Degeneration Mice. 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). (pp. 3513 - 3516). Montreal. Canada: IEEE. doi:10.1109/EMBC44109.2020.9175231
  • Xie, H. , Shek, C.H. , Wang, Y. & Chan, L.L.H. (Jul 2019). Effect of interphase gap duration and stimulus rate on threshold of visual cortical neurons in the rat. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). (pp. 1817 - 1820). Berlin. Germany: IEEE. doi:10.1109/EMBC.2019.8856829
  • Agadagba, S.K. , Li, X. & Chan, L.L.H. (Mar 2019). Electroencephalogram power alterations in retinal degeneration mice after prolonged transcorneal electrical stimulation. 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER). (pp. 219 - 222). San Francisco. United States: IEEE. doi:10.1109/NER.2019.8717067
  • Chow, J.P. , Chung, H.S. , Chan, L.L.H. , Judson, N. & Tang, S.C. (Nov 2017). Design of Wireless Power Transfer System for Devices Carried by a Freely Moving Animal in Cage. IEEE Energy Conversion Congress and Exposition (ECCE). (pp. 4398 - 4405). Cincinnati, OH. USA: 1-5 Oct. doi:10.1109/ECCE.2017.8096757
  • Wang, Y. , Chen, K. & Chan, L.L.H. (Sep 2017). Information Transmission in the Primary Visual Cortex of Retinal Degenerated Rats. 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). (pp. 3632 - 3635). Jeju Island. S. Korea: 11-15 Jul. doi:10.1109/EMBC.2017.8037644
  • Xu, H. , Chan, L.L.H. & Bermak, A. (Oct 2016). Novel Structure of Carbon Nanotube Micro Electrode for High-resolution Stimulation of Neurons. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). (pp. 6170 - 6173). Orlando, FL. USA: 16-20 Aug. doi:10.1109/EMBC.2016.7592137
  • Yang, L. & Chan, L.L.H. (Nov 2015). An ERP study about the effects of different spatial frequencies and orientations on human brain activity. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). (pp. 6202 - 6205). Milan. Italy: 25-29 Aug. doi:10.1109/EMBC.2015.7319809
  • Chow, J.P. , Chen, N. , Chung, H.S. & Chan, L.L.H. (Nov 2014). Modeling and experimentation of misalignment-tolerable loosely-coupled coil structure. IEEE Energy Conversion Congress and Exposition (ECCE). (pp. 5429 - 5436). Pittsburgh, PA. USA: 14-18 Sep. doi:10.1109/ECCE.2014.6954145
  • Chow, J.P. , Chen, N. , Chung, H.S. & Chan, L.L.H. (Sep 2013). Misalignment tolerable coil structure for biomedical applications with wireless power transfer. 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). (pp. 775 - 778). Osaka. Japan: 3-7 Jul. doi:10.1109/EMBC.2013.6609615
  • Chan, L.H. , Ray, A. , Thomas, B.B. , Humayun, M.S. & Weiland, J.D. (Oct 2008). In vivo study of response threshold in retinal degenerate model at different degenerate stages. 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). (pp. 1781 - 1784). Vancouver, BC. Canada: 20-25 Aug. doi:10.1109/IEMBS.2008.4649523
  • Ray, A. , Chan, L.H. , Thomas, B.B. , Humayun, M.S. & Weiland, J.D. (Dec 2006). Effects of prolonged stimulation at the electrode-retina interface. 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). (pp. 1285 - 1287). New York, NY. USA: 30 Aug.-3 Sept. doi:10.1109/IEMBS.2006.260805


Last update date : 03 Aug 2022