More than $2 trillion/year by 2020 in new technologies and products and 2 million jobs have been projected by nanotechnology. Nanomanufacturing is crucial to bring nanotechnology out of the laboratory into the factory for commercial scale-up and applications. This course aims to introduce the modern multidisciplinary nanomanufacturing to the students and get them prepared for the new industrial revolution led by rapid progresses in nanotechnology. It covers important topics in nanomanufacturing such as top-down and bottom-up manufacturing, reliability and defect control, and many key issues on how to conduct nanomanufacturing today and overcome its many technical barriers. Moreover, this course will also promote discovery learning through Web 2.0.