Department of Biomedical Engineering
City University of Hong Kong
Department of Biomedical Engineering
Prof. WANG, Dongan

Prof. WANG, Dongan

BEng & PhD (ZJU), FRSC (UK)

Professor

Research Interest

  • Functional biomaterials for tissue engineering and therapeutic cell delivery;
  • Nucleic acid delivery for therapeutic engineering;
  • Applications of stem cells for regenerative medicine;
  • Engineered biomimetic and pathological tissue platforms for in vitro drug evaluation.

    • Phone: +852 3442-9542
    Personal Email: dwang229@cityu.edu.hk
    Address: YEUNG-P7718

    Dr. Dong-An Wang is a Professor of Department of Biomedical Engineering in City University of Hong Kong. Dr. Wang has authored nearly 200 research and scholarly publications and numerous patents. The publications include those published in Nat Mater, Adv Mater, etc., some of which are editorially quoted by Science, Nat Mater, etc. Dr. Wang has been conferred with Best Paper Award by Elsevier and Euro Federation for Pharm Sci, and Biomaterials Science Prize by Royal Society of Chemistry. Dr. Wang is a Fellow of Royal Society of Chemistry. Dr. Wang is ranked as the Top 2% of the World's Most Highly Cited Scientists by Stanford University. Dr. Wang is a member of Biology & Medicine Panel, Research Grants Council (RGC), Hong Kong. Dr. Wang used to be Assoc Chair of School of Chemical and Biomedical Engineering, Nanyang Technological University Singapore; Acting Head of Department of Biomedical Engineering, City University of Hong Kong; and, Head of Research at Karolinska Institutet Ming Wai Lau Centre for Reparative Medicine. Dr. Wang is currently a Foreign Adjunct Professor at Department of Neuroscience, Karolinska Institutet.

    • Professor, Department of Biomedical Engineering (BME), City University of Hong Kong (CityU), 2018-
    • Foreign Adjunct Professor, Department of Neuroscience, Karolinska Institutet, 2024-
    • Associate/Assistant Professor, Bioengineering, School Chemical & Biomedical Engineering (SCBE), Nanyang Technological University (NTU, Singapore), 2005-2018
    • Postdoctoral Fellow, Tissue Engineering, Johns Hopkins University (US), 2002-2005
    • Postdoctoral Fellow, Gene Therapy, University of Tennessee Health Science Centre (US), 2001-2002

    • Acting Head, BME, CityU, 2022-2023
    • Head of Research (as a joint appointment), Karolinska Institutet Ming Wai Lau Centre of Reparative Medicine, 2020-2023
    • Program Director, Bioengineering, SCBE, NTU, 2016-2018
    • Associate Chair (Graduate Studies), SCBE, NTU, 2010-2014

    • Ph.D. - Polymer Biomaterials, Zhejiang University (China)
    • B.Eng. - Polymer Materials, Zhejiang University (China)

    2020~23 Top 2% of World's Most Highly Cited Scientists (Biomed Eng, reported by Stanford Univ)
    2019 Fellow of The Royal Society of Chemistry (FRSC, UK)
    2017 Biomaterials Science Poster Prize by Royal Society of Chemistry
    2013 Runners-Up, 2012 Materials Today Cover Competition, by Elsevier & Carl Zeiss.
    2011 Best Paper Award by European Federation for Pharmaceutical Sciences and Elsevier
    2009 Nanyang Award for Excellence in Teaching (2008), NTU, Singapore

    1. Zhou, H.Q., Zhang, Z., Mu, Y.L., Yao, H., Zhang, Y., Wang, D.A.*, “Harnessing Nanomedicine for Cartilage Repair: Design Considerations and Recent Advances in Biomaterials”, ACS Nano, (2024), doi: 10.1021/acsnano.4c00780.
    2. Hu, X., Jin, M., Sun, K., Zhang, Z., Wu, Z.L., Shi, J.L., Liu, P.L., Yao, H., Wang, D.A.*, “Type II collagen scaffolds repair critical-sized osteochondral defects under induced conditions of osteoarthritis in rat knee joints via inhibiting TGF-β-Smad1/5/8 signaling pathway”, Bioactive Materials, 35 (2024) 5: 416-428.
    3. Jin, M., Liu, B.H., Zhang, Z., Mu, Y.L., Ma, L., Yao, H., Wang, D.A.*, "Catechin-functionalized cationic lipopolymer based multicomponent nanomicelles for lung-targeting delivery", Advanced Materials, (2023), doi: 10.1002/adma.202302985
    4. Liu, B.H., Jin, M., Ma, C., Zhang, Z., Ma, L., Zhang, Y., Wang, D.A.*, “An Engineered Lymph Node Comprising Porous Collagen Scaffold with Hybridized Biological Signals Embedded in B Cell Membrane Coatings”, Biomaterials, 304 (2024): 122420.
    5. Zhou, H.Q., Mu, Y.L., Ma, C., Zhang, Z., Tao, C., Wang, D.A.*, “Rejuvenation of hyaline cartilaginous phenotype via 3D culture of dedifferentiated chondrocytes in a type II collagen-based scaffold: A mechanism study using chondrocyte membrane nanoaggregates as a coating of antagonist”, ACS Nano, 18 (2024) 3: 2077-2090.
    6. Wang, G.Q., Meng, X.Y., Wang P.Y., Wang, X.P., Liu, G.L., Wang, D.A.*, Fan, C.J. “A catechol bioadhesive for rapid hemostasis and healing of traumatic internal organs and major arteries”, Biomaterials, 291 (2022) 12: 121908.
    7. Ling, Y., Zhang, W.Y., Wang, P.Y., Xie, W.H., Yang, W., Wang, D.A.*, Fan, C.J.* “Three-dimensional (3D) hydrogel serves as a platform to identify potential markers of chondrocyte dedifferentiation by combining RNA sequencing”, Bioactive Materials, 6 (2021) 9: 2914-2926.
    8. Tao, C., Nie, X.L., Zhu, W.Z., Iqbal, J., Xu, C.J., Wang, D. A.*, “Autologous cell membrane coatings on tissue engineering xenografts for suppression and alleviation of acute host immune responses”, Biomaterials, 258 (2020): 120310.
    9. Nie, X.L., Chuah, Y.J., Zhu, W.Z., He, P.F., Peck, Y., Wang, D. A.*, “Decellularized Tissue Engineered Hyaline Cartilage Graft for Articular Cartilage Repair”, Biomaterials, 235 (2020): 119821.
    10. Fu, J. Y., Wang, D. A.*, “In Situ Organ-Specific Vascularization in Tissue Engineering”, Trends in Biotechnology, 36 (2018) 8: 834-849.
    11. Zhu, W. Z., Peck, Y., Iqbal, J., Wang, D. A.*, “A novel DOPA-albumin based tissue adhesive for internal medical applications”, Biomaterials, 147 (2017): 99-115.
    12. Leong, W. Y., Wang, D. A.*, “Cell-laden Polymeric Microspheres for Biomedical Applications”, Trends in Biotechnology, 33 (2015), 11: 653-666.
    13. Peck, Y., Ng, L. Y., Goh, J. Y. L, Gao, C. Y., Wang, D. A.*, “A three-dimensionally engineered biomimetic cartilaginous tissue model for osteoarthritic drug evaluation”, Molecular Pharmaceutics, 11 (2014), 7: 1997-2008
    14. Lau, T. T., Ho, L. W., Wang, D. A.*, “Hepatogenesis of murine induced pluripotent stem cells in 3D micro-cavitary hydrogel system for liver regeneration”, Biomaterials, 34 (2013), 28: 6659-6669.
    15. Lau, T. T., Lee, L. Q. P., Vo, B. N., Su, K., Wang, D. A.*, “Inducing ossification in an engineered 3D scaffold-free living cartilage template”, Biomaterials, 33 (2012), 33: 8406-8417.
    16. Su, K., Lau, T. T., Leong, W.Y., Gong, Y.H., Wang, D. A.*, “Creating a Living Hyaline Cartilage Graft Free of Non-Cartilaginous Constituents: An Intermediate Role of Biomaterial Scaffold”, Advanced Functional Materials, 22 (2012), 5: 972-978.
    17. Wang, C. M., Varshney, R. R., Wang, D. A.*, “Therapeutic Cell Delivery and Fate Control in Hydrogels and Hydrogel Hybrids”, In: “Therapeutic Cell Delivery for in situ Regenerative Medicine”, Advanced Drug Delivery Reviews, 62 (2010), 7-8: 699-710.
    18. Varshney, R. R., Zhou, R. J., Hao, J. H., Yeo, S. S., Chooi, W. H., Fan, J. B., Wang, D. A.*, “Chondrogenesis of Synovium-Derived Mesenchymal Stem Cells in Gene-Transferred Co-Culture System”, Biomaterials, 31 (2010), 26: 6876-6891.
    19. Zhang, F., Yao, Y. C., Hao, J. H., Zhou, R. J., Liu, C. Z., Gong, Y. H., Wang, D. A.*, “A dual-functioning adenoviral vector encoding both transforming growth factor-β3 and shRNA silencing type I collagen: construction and controlled release for chondrogenesis”, Journal of Controlled Release, 142 (2010), 1: 70-77.
    20. Wang, C. M., Adrianus, G. N., Sheng, N., Toh, S. K., Gong, Y. H., Wang, D. A.* “In vitro performance of an injectable hydrogel / microsphere based immunocyte delivery system for localised anti-tumour activity”, Biomaterials, 30 (2009), 36: 6986-6995.
    21. Shi, X. T., Wang, Y. J., Varshney, R. R., Ren, L., Zhang, F., Wang, D. A.*, “In Vitro Osteogenesis of Synovium Stem Cells Induced by Controlled Release of Bisphosphate Additives from Microspherical Mesoporous Silica Composite”, Biomaterials, 30 (2009), 23-24: 3996-4005.
    22. Wang, C. M., Gong, Y. H., Zhong, Y., Yao, Y.C., Su, K., Wang, D. A.*, “The control of anchorage-dependent cell behavior within a hydrogel / microcarrier system in an osteogenic model”, Biomaterials, 30 (2009), 13: 2259-2269.
    23. Liu, Y., Ramanath, H. S., Wang, D. A.*, “Tendon Tissue Engineering Using Scaffold Enhancing Strategies”, Trends in Biotechnology, 26 (2008), 4: 201-209.
    24. Wang, D. A., Varghese, S., Sharma, B., Strehin, I., Fermanian, S., Gorham J., Fairbrother, H.D, Cascio B, Elisseeff, J.H.*, “Multifunctional Chondroitin Sulphate for Cartilage Tissue-Biomaterial Integration”, Nature Materials, 6 (2007), 5: 385-392.
    25. Wang, D. A., Williams, C. G., Yang, F., Elisseeff, J. H.*, "Enhancing the Tissue-Biomaterial Interface: Tissue-initiated Integration of Biomaterials", Advanced Functional Materials, 14 (2004), 12: 1152-1159.
    26. Wang, D A, Williams,CG, Li, Q, Sharma, B, Elisseeff, JH*, "Synthesis and characterization of a novel degradable phosphate-containing hydrogel", Biomaterials, 24 (2003), 22: 3969-3980.
    27. Wang, D. A., Narang, A. S., Kotb, M., Gaber, A. O., Miller, D. D., Kim, S. W., Mahato, R. I.*, "Novel Branched Poly(ethylenimine)-Cholesterol Water-Soluble Lipopolymers for Gene Delivery", Biomacromolecules, 3 (2002),6:1197-1207.
    28. Wang, D. A., Ji, J., Sun, Y. H., Shen, J. C., Feng, L. X., Elisseeff, J. H. "In situ Immobilization of Proteins and RGD Peptide on Polyurethane Surfaces via Poly(ethylene oxide) Coupling-polymers for Human Endothelial Cell Growth", Biomacromolecules, 3 (2002), 6: 1286-1295.
    29. Wang, D. A., Ji, J., Gao, C.Y., Yu, G. H., Feng, L. X.*, "Surface Coating of Stearyl Poly (ethylene oxide) Coupling-polymer on Polyurethane Guiding Catheters with Poly(ether urethane) Film Building Additive for Biomedical Applications", Biomaterials, 22 (2001), 12: 1549-1562.
    30. Wang, D. A., Ji, J., Feng, L.X.*, "Surface analysis of poly(ether urethane) blending stearyl polycethylene oxide coupling polymer", Macromolecules, 33 (2000), 22: 8472-8478.

    Last modified on 10 April, 2024